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Gene Detail
membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms Acvrinp1, Magi-2, mKIAA0705, S-SCAM
Feature Type protein coding gene
Genetic Map
Chromosome 5
8.60 cM, cytoband A3
Detailed Genetic Map ± 1 cM

Mapping data(2)
Sequence Map
Chr5:19227046-20704798 bp, + strand
From VEGA annotation of GRCm38

  1477753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:8189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human Homolog MAGI2, membrane associated guanylate kinase, WW and PDZ domain containing 2
NCBI Gene ID 9863
neXtProt AC  NX_Q86UL8
Human Synonyms  ACVRIP1, AIP1, AIP-1, ARIP1, MAGI-2, SSCAM
Human Chr (Location)  7q21; chr7:78017057-79453805 (-)  GRCh38
alleles, and
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a knock-out allele die within 24 hours after birth and possess hippocampal neurons that exhibit significantly altered dendritic spine morphologies with elongated necks.
Magi2 interacts with 394 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (45 annotations)
Process cellular response to nerve growth factor stimulus, cytoplasmic transport, ...
Component cell junction, cytoplasm, ...
Function beta-1 adrenergic receptor binding, PDZ domain binding, ...
External Resources: FuncBase
Literature Summary: (5 records)
Data Summary: Results (65)    Tissues (62)    Images (1)
Theiler Stages: 13, 15, 17, 19, 20, 23
Assay TypeResults
RNA in situ 65
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(11) cDNA(10) Other(1)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000025140 (Evidence)
Ensembl Gene ModelENSMUSG00000067798 (Evidence), ENSMUSG00000073174 (Evidence), ENSMUSG00000040003 (Evidence)
Entrez Gene50791 (Evidence)
DFCITC1582217, TC1590895, TC1593451, TC1650950, TC1670859, TC1678568, TC1687339
DoTSDT.101126373, DT.101209401, DT.101405144, DT.101739025, DT.60100567
NIA Mouse Gene IndexU005327, U043929
Consensus CDS ProjectCCDS39019.1, CCDS51424.1, CCDS51425.1
International Mouse Knockout Project StatusMagi2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025140 VEGA Gene Model | MGI Sequence Detail 1477753 C57BL/6J ±  kb
transcript OTTMUST00000061859 VEGA | MGI Sequence Detail 4848 Not Applicable 
polypeptide OTTMUSP00000030430 VEGA | MGI Sequence Detail 1275 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(26) UniProt(5)
Polymorphisms SNPs within 2kb(9938 from dbSNP Build 137)
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001202 WW domain
Protein Ontology PR:000010084 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
References (Earliest) J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
(Latest) J:189715 Chen H, et al., Identification of novel markers of mouse fetal ovary development. PLoS One. 2012;7(7):e41683
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory