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Magi2
Gene Detail
Symbol

Name
ID
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
MGI:1354953
Synonyms
Acvrinp1, Magi-2, mKIAA0705, S-SCAM
Feature Type
protein coding gene
Genetic Map
Chromosome 5
8.60 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:19227046-20704798 bp, + strand
From VEGA annotation of GRCm38

  1477753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: MAGI2
Gene Tree: Magi2

Human
homologs
MAGI2, membrane associated guanylate kinase, WW and PDZ domain containing 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9863
neXtProt AC: NX_Q86UL8

Human Synonyms: ACVRIP1, AIP1, AIP-1, ARIP1, MAGI-2, SSCAM

Human Chr (Location): 7q21; chr7:78017055-79453805 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele die within 24 hours after birth and possess hippocampal neurons that exhibit significantly altered dendritic spine morphologies with elongated necks.
 
Human Diseases Modeled in Mice Using Magi2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Magi2 interacts with 394 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (65)    Tissues (62)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase magi2    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000025140 (Evidence)
Ensembl Gene Model ENSMUSG00000040003 (Evidence)
Entrez Gene 50791 (Evidence)
DFCI TC1582217, TC1650950, TC1593451, TC1590895, TC1670859, TC1687339, TC1678568
DoTS DT.101126373, DT.101209401, DT.101739025, DT.101405144, DT.60100567
NIA Mouse Gene Index U043929, U005327
Consensus CDS Project CCDS39019.1, CCDS51424.1, CCDS51425.1
International Mouse Phenotyping Consortium Status Magi2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025140 VEGA Gene Model | MGI Sequence Detail 1477753 C57BL/6J ±  kb
transcript OTTMUST00000061859 VEGA | MGI Sequence Detail 4848 Not Applicable 
polypeptide OTTMUSP00000030430 VEGA | MGI Sequence Detail 1275 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(28) UniProt(3)
Polymorphisms
SNPs within 2kb(9938 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001202 WW domain
Protein Ontology PR:000010084 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
References
(Earliest) J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
(Latest) J:216062 Ihara K, et al., MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney. Am J Pathol. 2014 Oct;184(10):2699-708
All references(47)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory