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Magi2 Gene Detail
Summary
  • Symbol
    Magi2
  • Name
    membrane associated guanylate kinase, WW and PDZ domain containing 2
  • Synonyms
    Acvrinp1, Magi-2, mKIAA0705, S-SCAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354953
    NCBI Gene: 50791
  • Gene Overview
    MyGene.info: MAGI2
Location & Maps
more
  • Sequence Map
    Chr5:19227036-20704792 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1477757 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAGI2, membrane associated guanylate kinase, WW and PDZ domain containing 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAGI2, membrane associated guanylate kinase, WW and PDZ domain containing 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACVRIP1, AIP1, AIP-1, ARIP1, MAGI-2, SSCAM
  • Links
    NCBI Gene ID: 9863
    neXtProt AC: NX_Q86UL8

  • Chr Location
    7q21; chr7:78017055-79453805 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Magi2 mouse models

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 4 alleles in 6 genetic backgrounds
    3 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    4 involving Magi2
  • Incidental Mutations
Homozygotes for a null allele show neonatal death and hippocampal neurons with altered dendritic spine morphology. Homozygotes for a different null allele die neonatally due to anuria and podocyte anomalies. Mice lacking all three isoforms develop proteinuria, podocytopathy and die of renal failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025140 VEGA Gene Model | MGI Sequence Detail 1477757 C57BL/6J ±  kb
transcript OTTMUST00000136790 VEGA | MGI Sequence Detail 4785 Not Applicable  
polypeptide OTTMUSP00000072151 VEGA | MGI Sequence Detail 1414 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    9900 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000010084 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
  • InterPro Domains
    IPR020590 Guanylate kinase, conserved site
    IPR008144 Guanylate kinase-like domain
    IPR008145 Guanylate kinase/L-type calcium channel beta subunit
    IPR030036 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
    IPR001478 PDZ domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001202 WW domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
  • Latest
    J:216062 Ihara K, et al., MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney. Am J Pathol. 2014 Oct;184(10):2699-708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory