About   Help   FAQ
Magi2
Gene Detail
Symbol

Name
ID
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
MGI:1354953
Synonyms
Acvrinp1, Magi-2, mKIAA0705, S-SCAM
Feature Type
protein coding gene
Genetic Map
Chromosome 5
8.60 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:19227046-20704798 bp, + strand
From VEGA annotation of GRCm38

  1477753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human
homologs
Human Homolog MAGI2, membrane associated guanylate kinase, WW and PDZ domain containing 2
NCBI Gene ID 9863
neXtProt AC  NX_Q86UL8
Human Synonyms  ACVRIP1, AIP1, AIP-1, ARIP1, MAGI-2, SSCAM
Human Chr (Location)  7q21; chr7:78017057-79453805 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die within 24 hours after birth and possess hippocampal neurons that exhibit significantly altered dendritic spine morphologies with elongated necks.
 
Interactions
Magi2 interacts with 394 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cellular response to nerve growth factor stimulus, cytoplasmic transport, ...
Component cell junction, cytoplasm, ...
Function beta-1 adrenergic receptor binding, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (65)    Tissues (62)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Other(1)
Microarray probesets(4)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025140 VEGA Gene Model | MGI Sequence Detail 1477753 C57BL/6J ±  kb
transcript OTTMUST00000061859 VEGA | MGI Sequence Detail 4848 Not Applicable 
polypeptide OTTMUSP00000030430 VEGA | MGI Sequence Detail 1275 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(26) UniProt(5)
Polymorphisms
SNPs within 2kb(9938 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001202 WW domain
Protein Ontology PR:000010084 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
References
(Earliest) J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
(Latest) J:213553 Balbas MD, et al., MAGI-2 scaffold protein is critical for kidney barrier function. Proc Natl Acad Sci U S A. 2014;
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory