Nox4 MGI Mouse Gene Detail - MGI:1354184

Symbol

Nox4
Name

NADPH oxidase 4

Feature Type

protein coding gene
IDs

MGI:1354184
NCBI Gene: 50490
Gene Overview

MyGene.info: NOX4
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:87246096-87398710 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 48.96 cM
Mapping Data

2 experiments

SNPs within 2kb

1354 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354184	protein coding gene	Chr7:87244430-87398710 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032489	protein coding gene	Chr7:89586701-89740799 (+)
A/J	MGP_AJ_G0032463	protein coding gene	Chr7:87433871-87584347 (+)
AKR/J	MGP_AKRJ_G0032399	protein coding gene	Chr7:89543313-89697885 (+)
BALB/cJ	MGP_BALBcJ_G0032474	protein coding gene	Chr7:87125663-87274273 (+)
C3H/HeJ	MGP_C3HHeJ_G0032189	protein coding gene	Chr7:89918500-90067018 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032972	protein coding gene	Chr7:93136522-93291004 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029967	protein coding gene	Chr7:90122800-90269291 (+)
CAST/EiJ	MGP_CASTEiJ_G0031516	protein coding gene	Chr7:81306507-81466183 (+)
CBA/J	MGP_CBAJ_G0032155	protein coding gene	Chr7:96174650-96339594 (+)
DBA/2J	MGP_DBA2J_G0032308	protein coding gene	Chr7:85935048-86080144 (+)
FVB/NJ	MGP_FVBNJ_G0032264	protein coding gene	Chr7:85822548-85967941 (+)
LP/J	MGP_LPJ_G0032397	protein coding gene	Chr7:90841639-90996656 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032298	protein coding gene	Chr7:97037922-97240900 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032994	protein coding gene	Chr7:88799072-88944329 (+)
PWK/PhJ	MGP_PWKPhJ_G0031234	protein coding gene	Chr7:78957835-79107653 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031077	protein coding gene	Chr7:76063211-76236250 (+)
WSB/EiJ	MGP_WSBEiJ_G0031633	protein coding gene	Chr7:89425622-89580304 (+)

Human Ortholog

NOX4, NADPH oxidase 4

Vertebrate Orthologs

9

Human Ortholog

NOX4, NADPH oxidase 4
Orthology source: HomoloGene, HGNC
Synonyms

KOX, KOX-1, RENOX
Links

HGNC:7891

NCBI Gene ID: 50507

neXtProt AC: NX_Q9NPH5

UniProt: Q9NPH5
Chr Location

11q14.3; chr11:89324353-89589611 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41065
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NOX4
Gene Tree

Nox4

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Phenotype Summary

34 phenotypes from 10 alleles in 10 genetic backgrounds
81 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

3
Targeted

8
Transgenic

4
Genomic Mutations

4 involving Nox4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display increased heart damage following pressure overload. Mice with a cardiomyocyte specific deletion show decreased damage following pressure overload. Mice homozygous for a different knock-out allele exhibit decreased suseptibility to bleomycin-induced fibrosis.

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All GO Annotations

55
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

644
Tissues

12
cDNA Data

47
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Nox4 interacts with 304 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

74
RefSeq

15
UniProt

5
CCDS

CCDS21437.1
UniGene

31748

Ensembl

ENSMUSG00000030562 (Evidence)
NCBI Gene

50490

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030562	Ensembl Gene Model \| MGI Sequence Detail	152615	C57BL/6J	± kb
transcript	ENSMUST00000068829	Ensembl \| MGI Sequence Detail	1861	Not Applicable
polypeptide	ENSMUSP00000070039	Ensembl \| MGI Sequence Detail	592	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001826 NADPH oxidase 4

(term hierarchy)
EC

1.6.3.-
InterPro Domains

IPR000778 Cytochrome b245, heavy chain

IPR013112 FAD-binding 8

IPR017927 FAD-binding domain, ferredoxin reductase-type

IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

IPR013121 Ferric reductase, NAD binding domain

IPR013130 Ferric reductase transmembrane component-like domain

IPR029650 NADPH oxidase 1

IPR017938 Riboflavin synthase-like beta-barrel

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All nucleic 52

cDNA 49

Primer pair 2

Other 1

Microarray probesets 5

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MGI:2142019

Summaries

All 179

Developmental Gene Expression 11

Gene Ontology 13

Phenotypes 81
Earliest

J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
Latest

J:293332 Plecita-Hlavata L, et al., Glucose-Stimulated Insulin Secretion Fundamentally Requires H2O2 Signaling by NADPH Oxidase 4. Diabetes. 2020 Jul;69(7):1341-1354

TSS for Nox4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67600	Chr7:87246656-87246661 (+)	563 bp
Tssr67601	Chr7:87246687-87246692 (+)	594 bp
Tssr67602	Chr7:87246708-87246719 (+)	618 bp
Tssr67603	Chr7:87246788-87246807 (+)	702 bp
Tssr67604	Chr7:87246819-87246832 (+)	730 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/13/2020 MGI 6.16