About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Nox4 Gene Detail
Summary
  • Symbol
    Nox4
  • Name
    NADPH oxidase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354184
    NCBI Gene: 50490
  • Gene Overview
    MyGene.info: NOX4
Location & Maps
more
  • Sequence Map
    Chr7:87246096-87398710 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      152615 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NOX4, NADPH oxidase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NOX4, NADPH oxidase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KOX, KOX-1, RENOX
  • Links
    NCBI Gene ID: 50507
    neXtProt AC: NX_Q9NPH5

  • Chr Location
    11q14.2-q21; chr11:89324353-89589611 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 41065
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
  • HCOP
    human homology predictions: NOX4
  • Gene Tree
    Nox4
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 9 alleles in 9 genetic backgrounds
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Radiation induced
    3
  • Targeted
    6
  • Transgenic
    4
  • Genomic Mutations
    4 involving Nox4
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a null allele display increased heart damage following pressure overload. Mice with a cardiomyocyte specific deletion show decreased damage following pressure overload. Mice homozygous for a different knock-out allele exhibit decreased suseptibility to bleomycin-induced fibrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    13
  • Tissues
    12
  • cDNA Data
    46
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021141 VEGA Gene Model | MGI Sequence Detail 152615 C57BL/6J ±  kb
transcript OTTMUST00000050053 VEGA | MGI Sequence Detail 1861 Not Applicable  
polypeptide OTTMUSP00000023306 VEGA | MGI Sequence Detail 592 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1354 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001826 NADPH oxidase 4
  • EC
    1.6.3.-
  • InterPro Domains
    IPR000778 Cytochrome b245, heavy chain
    IPR013112 FAD-binding 8
    IPR017927 Ferredoxin reductase-type FAD-binding domain
    IPR013121 Ferric reductase, NAD binding domain
    IPR013130 Ferric reductase transmembrane component-like domain
    IPR017938 Riboflavin synthase-like beta-barrel
Molecular
Reagents
less
  • All nucleic 51
    cDNA 48
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142019
References
more
  • Summaries
    All 79
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 51
  • Earliest
    J:116373 Geiszt M, et al., Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8010-4
  • Latest
    J:233008 Onetti Y, et al., NADPH oxidase 4 attenuates cerebral artery changes during the progression of Marfan syndrome. Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1081-90
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory