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Nox4
Gene Detail
Symbol

Name
ID
Nox4
NADPH oxidase 4
MGI:1354184
Feature Type
protein coding gene
Genetic Map
Chromosome 7
48.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:87246096-87398710 bp, + strand
From VEGA annotation of GRCm38

  152615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Nox4

Human
homologs
Human Homolog NOX4, NADPH oxidase 4
NCBI Gene ID 50507
neXtProt AC  NX_Q9NPH5
Human Synonyms  KOX, KOX-1, RENOX
Human Chr (Location)  11q14.2-q21; chr11:89324353-89589611 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display increased heart damage following pressure overload. Mice with a cardiomyocyte specific deletion show decreased damage following pressure overload. Mice homozygous for a different knock-out allele exhibit decreased suseptibility to bleomycin-induced fibrosis.
 
Interactions
Nox4 interacts with 304 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process bone resorption, cardiac muscle cell differentiation, ...
Component apical plasma membrane, cell junction, ...
Function modified amino acid binding, NAD(P)H oxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (13)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 10
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(48) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021141 (Evidence)
Ensembl Gene ModelENSMUSG00000030562 (Evidence)
Entrez Gene50490 (Evidence)
UniGene31748
DFCITC1617760, TC1577594, TC1682283
DoTSDT.101368665, DT.101244992, DT.97356459, DT.482212
NIA Mouse Gene IndexU008346
EC1.6.3.-
Consensus CDS ProjectCCDS21437.1
International Mouse Knockout Project StatusNox4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021141 VEGA Gene Model | MGI Sequence Detail 152615 C57BL/6J ±  kb
transcript OTTMUST00000050053 VEGA | MGI Sequence Detail 2007 Not Applicable 
polypeptide OTTMUSP00000023306 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(12) UniProt(9)
Polymorphisms
SNPs within 2kb(1369 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1373)
Protein-related
information
ResourceIDDescription
InterPro IPR000778 Cytochrome b245, heavy chain
InterPro IPR013112 FAD-binding 8
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR013121 Ferric reductase, NAD binding
InterPro IPR013130 Ferric reductase transmembrane component-like domain
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000001826 NADPH oxidase 4
References
(Earliest) J:65638 Lambeth JD, et al., Novel homologs of gp91phox. Trends Biochem Sci. 2000 Oct;25(10):459-61
(Latest) J:213317 Matsushima S, et al., Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1alpha and upregulation of peroxisome proliferator-activated receptor-alpha. Circ Res. 2013 Apr 12;112(8):1135-49
All references(63)
Other
accession IDs
MGI:2142019

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory