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Nox4 Gene Detail
Summary
  • Symbol
    Nox4
  • Name
    NADPH oxidase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354184
    NCBI Gene: 50490
  • Gene Overview
    MyGene.info: NOX4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:87246096-87398710 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      152615 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NOX4, NADPH oxidase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NOX4, NADPH oxidase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KOX, KOX-1, RENOX
  • Links
    NCBI Gene ID: 50507
    neXtProt AC: NX_Q9NPH5
    UniProt: Q9NPH5

  • Chr Location
    11q14.3; chr11:89324353-89589611 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 41065
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NOX4
  • Gene Tree
    Nox4
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 9 alleles in 9 genetic backgrounds
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased heart damage following pressure overload. Mice with a cardiomyocyte specific deletion show decreased damage following pressure overload. Mice homozygous for a different knock-out allele exhibit decreased suseptibility to bleomycin-induced fibrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    13
  • Tissues
    12
  • cDNA Data
    46
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021141 VEGA Gene Model | MGI Sequence Detail 152615 C57BL/6J ±  kb
    transcript OTTMUST00000050053 VEGA | MGI Sequence Detail 1861 Not Applicable  
    polypeptide OTTMUSP00000023306 VEGA | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1354 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142019
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 62
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:261153 Geis C, et al., NOX4 is an early initiator of neuropathic pain. Exp Neurol. 2017 Feb;288(None):94-103
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory