Nox4
Gene Detail

Symbol

Name
ID

Nox4
NADPH oxidase 4
MGI:1354184

Feature Type

protein coding gene

Genetic Map

Chromosome 7
48.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:87246096-87398710 bp, + strand From VEGA annotation of GRCm38   152615 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:41065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Nox4

Human
homologs

Human Homolog		NOX4, NADPH oxidase 4
NCBI Gene ID		50507
neXtProt AC		NX_Q9NPH5
Human Synonyms		KOX, KOX-1, RENOX
Human Chr (Location)		11q14.2-q21; chr11:89324353-89589611 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele display increased heart damage following pressure overload. Mice with a cardiomyocyte specific deletion show decreased damage following pressure overload. Mice homozygous for a different knock-out allele exhibit decreased suseptibility to bleomycin-induced fibrosis.

 

Interactions

Nox4 interacts with 304 markers (Mir7-1, Mir9-1, Mir9-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (39 annotations)

Process	bone resorption, cardiac muscle cell differentiation, ...
Component	apical plasma membrane, cell junction, ...
Function	modified amino acid binding, NAD(P)H oxidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (13)    Tissues (12)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	3
RT-PCR	10

cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(51) cDNA(48) Primer pair(2) Other(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000021141 (Evidence)
Ensembl Gene Model	ENSMUSG00000030562 (Evidence)
Entrez Gene	50490 (Evidence)
UniGene	31748
DFCI	TC1682283, TC1617760, TC1577594
DoTS	DT.97356459, DT.482212, DT.101368665, DT.101244992
NIA Mouse Gene Index	U008346
EC	1.6.3.-
Consensus CDS Project	CCDS21437.1
International Mouse Knockout Project Status	Nox4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021141	VEGA Gene Model | MGI Sequence Detail	152615	C57BL/6J
transcript	OTTMUST00000050053	VEGA | MGI Sequence Detail	2007	Not Applicable
polypeptide	OTTMUSP00000023306	VEGA | MGI Sequence Detail	592	Not Applicable

All sequences(81) RefSeq(12) UniProt(9)

Polymorphisms

SNPs within 2kb(1369 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1373)

Protein-related
information

Resource	ID	Description
InterPro	IPR000778	Cytochrome b245, heavy chain
InterPro	IPR013112	FAD-binding 8
InterPro	IPR017927	Ferredoxin reductase-type FAD-binding domain
InterPro	IPR013121	Ferric reductase, NAD binding
InterPro	IPR013130	Ferric reductase transmembrane component-like domain
InterPro	IPR017938	Riboflavin synthase-like beta-barrel
Protein Ontology	PR:000001826	NADPH oxidase 4

References

(Earliest) J:65638 Lambeth JD, et al., Novel homologs of gp91phox. Trends Biochem Sci. 2000 Oct;25(10):459-61
(Latest) J:215348 Hecker L, et al., Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med. 2014 Apr 9;6(231):231ra47
All references(64)

Other
accession IDs

MGI:2142019