Nox4 MGI Mouse Gene Detail - MGI:1354184

Nox4 Gene Detail

Symbol

Nox4
Name

NADPH oxidase 4

Feature Type

protein coding gene
IDs

MGI:1354184
NCBI Gene: 50490
Gene Overview

MyGene.info: NOX4

Sequence Map

Chr7:87246096-87398710 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

152615 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 48.96 cM
Mapping Data

2 experiments

Human Ortholog

NOX4, NADPH oxidase 4

Vertebrate Orthologs

9

Human Ortholog

NOX4, NADPH oxidase 4
Orthology source: HomoloGene, HGNC
Synonyms

KOX, KOX-1, RENOX
Links

HGNC:7891

NCBI Gene ID: 50507

neXtProt AC: NX_Q9NPH5

UniProt: Q9NPH5
Chr Location

11q14.3; chr11:89324353-89589611 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41065
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NOX4
Gene Tree

Nox4

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Phenotype Summary

30 phenotypes from 9 alleles in 9 genetic backgrounds
59 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Radiation induced

3
Targeted

7
Transgenic

4
Genomic Mutations

4 involving Nox4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

Mice homozygous for a null allele display increased heart damage following pressure overload. Mice with a cardiomyocyte specific deletion show decreased damage following pressure overload. Mice homozygous for a different knock-out allele exhibit decreased suseptibility to bleomycin-induced fibrosis.

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All GO Annotations

43
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

13
Tissues

12
cDNA Data

46
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Nox4 interacts with 304 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

73
RefSeq

16
UniProt

5
CCDS

CCDS21437.1
UniGene

31748

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021141	VEGA Gene Model \| MGI Sequence Detail	152615	C57BL/6J	± kb
transcript	OTTMUST00000050053	VEGA \| MGI Sequence Detail	1861	Not Applicable
polypeptide	OTTMUSP00000023306	VEGA \| MGI Sequence Detail	592	Not Applicable

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SNPs within 2kb

1354 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000001826 NADPH oxidase 4

(term hierarchy)
EC

1.6.3.-
InterPro Domains

IPR000778 Cytochrome b245, heavy chain

IPR013112 FAD-binding 8

IPR017927 Ferredoxin reductase-type FAD-binding domain

IPR013121 Ferric reductase, NAD binding domain

IPR013130 Ferric reductase transmembrane component-like domain

IPR017938 Riboflavin synthase-like beta-barrel

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All nucleic 51

cDNA 48

Primer pair 2

Other 1

Microarray probesets 5

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MGI:2142019

Summaries

All 112

Developmental Gene Expression 7

Gene Ontology 10

Phenotypes 59
Earliest

J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
Latest

J:240885 Bernard K, et al., NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway. J Biol Chem. 2017 Feb 17;292(7):3029-3038

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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