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Nox4 Gene Detail
Summary
  • Symbol
    Nox4
  • Name
    NADPH oxidase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354184
    NCBI Gene: 50490
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:86895304-87047918 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354184
 protein coding gene Chr7:86893638-87047918 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032489
 protein coding gene Chr7:89586701-89740799 (+)
A/J MGP_AJ_G0032463
 protein coding gene Chr7:87433871-87584347 (+)
AKR/J MGP_AKRJ_G0032399
 protein coding gene Chr7:89543313-89697885 (+)
BALB/cJ MGP_BALBcJ_G0032474
 protein coding gene Chr7:87125663-87274273 (+)
C3H/HeJ MGP_C3HHeJ_G0032189
 protein coding gene Chr7:89918500-90067018 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032972
 protein coding gene Chr7:93136522-93291004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029967
 protein coding gene Chr7:90122800-90269291 (+)
CAST/EiJ MGP_CASTEiJ_G0031516
 protein coding gene Chr7:81306507-81466183 (+)
CBA/J MGP_CBAJ_G0032155
 protein coding gene Chr7:96174650-96339594 (+)
DBA/2J MGP_DBA2J_G0032308
 protein coding gene Chr7:85935048-86080144 (+)
FVB/NJ MGP_FVBNJ_G0032264
 protein coding gene Chr7:85822548-85967941 (+)
LP/J MGP_LPJ_G0032397
 protein coding gene Chr7:90841639-90996656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032298
 protein coding gene Chr7:97037922-97240900 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032994
 protein coding gene Chr7:88799072-88944329 (+)
PWK/PhJ MGP_PWKPhJ_G0031234
 protein coding gene Chr7:78957835-79107653 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031077
 protein coding gene Chr7:76063211-76236250 (+)
WSB/EiJ MGP_WSBEiJ_G0031633
 protein coding gene Chr7:89425622-89580304 (+)



Homology
more
  • Human Ortholog
    NOX4, NADPH oxidase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOX4, NADPH oxidase 4
  • Synonyms
    KOX, KOX-1, RENOX
  • Links
    NCBI Gene ID: 50507
    UniProt: Q9NPH5

  • Chr Location
    11q14.3; chr11:89324353-89589557 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 10 alleles in 11 genetic backgrounds
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased heart damage following pressure overload. Mice with a cardiomyocyte specific deletion show decreased damage following pressure overload. Mice homozygous for a different knock-out allele exhibit decreased suseptibility to bleomycin-induced fibrosis. Another homozygous knockout suppresses inflammatory reactions and reduces susceptibility to LPS-induced acute kidney disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    14
  • cDNA Data
    47
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030562 Ensembl Gene Model | MGI Sequence Detail 152615 C57BL/6J ±  kb
    transcript ENSMUST00000068829 Ensembl | MGI Sequence Detail 1861 Not Applicable  
    polypeptide ENSMUSP00000070039 Ensembl | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 49
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142019
    References
    more
    • Summaries
      All 247
      Developmental Gene Expression 11
      Gene Ontology 19
      Phenotypes 127
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:354856 Kim JY, et al., NADPH oxidase 4 deficiency promotes hepatocellular carcinoma arising from hepatic fibrosis by inducing M2-macrophages in the tumor microenvironment. Sci Rep. 2024 Sep 27;14(1):22358
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory