About   Help   FAQ
Eif2ak4 Gene Detail
Summary
  • Symbol
    Eif2ak4
  • Name
    eukaryotic translation initiation factor 2 alpha kinase 4
  • Synonyms
    GCN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353427
    NCBI Gene: 27103
  • Gene Overview
    MyGene.info: EIF2AK4
Location & Maps
more
  • Sequence Map
    Chr2:118388618-118475234 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86617 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.40 cM, cytoband E5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4
    Orthology source: HomoloGene
  • Synonyms
    GCN2, PVOD2
  • Links
    NCBI Gene ID: 440275
    neXtProt AC: NX_Q9P2K8

  • Chr Location
    15q15.1; chr15:39934124-40035596 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human EIF2AK4 associations

Human Disease Mouse Models
       Pulmonary Venoocclusive Disease 2, Autosomal Recessive; PVOD2   OMIM: 234810
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 7 genetic backgrounds
    1 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Eif2ak4
  • Incidental Mutations
Homozygotes for a null allele have altered feeding behavior, synaptic plasticity and dendritic cell function. Homozygotes for another null allele show enhanced muscle loss and morbidity after amino acid deprivation. Homozygotes for an ENU-induced allele show higher susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015229 VEGA Gene Model | MGI Sequence Detail 86617 C57BL/6J ±  kb
transcript OTTMUST00000036076 VEGA | MGI Sequence Detail 5212 Not Applicable  
polypeptide OTTMUSP00000016209 VEGA | MGI Sequence Detail 1648 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1012 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 65
    Primer pair 4

    Microarray probesets 3
References
more
  • Summaries
    All 87
    Developmental Gene Expression 3
    Gene Ontology 20
    Phenotypes 50
  • Earliest
    J:113815 Dever TE, et al., Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell. 1992 Feb 7;68(3):585-96
  • Latest
    J:232715 Ravindran R, et al., The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016 Mar 24;531(7595):523-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory