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Eif2ak4 Gene Detail
Summary
  • Symbol
    Eif2ak4
  • Name
    eukaryotic translation initiation factor 2 alpha kinase 4
  • Synonyms
    GCN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353427
    NCBI Gene: 27103
  • Gene Overview
    MyGene.info: EIF2AK4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118388618-118475234 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.40 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1012 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353427
protein coding gene Chr2:118388581-118475234 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026314
protein coding gene Chr2:121073479-121160891 (+)
A/J MGP_AJ_G0026275
protein coding gene Chr2:116159389-116245526 (+)
AKR/J MGP_AKRJ_G0026254
protein coding gene Chr2:119418913-119505240 (+)
BALB/cJ MGP_BALBcJ_G0026288
protein coding gene Chr2:116412444-116500293 (+)
C3H/HeJ MGP_C3HHeJ_G0026034
protein coding gene Chr2:119868201-119958296 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026735
protein coding gene Chr2:125072581-125165959 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024115
protein coding gene Chr2:111199397-111292041 (+)
CAST/EiJ MGP_CASTEiJ_G0025496
protein coding gene Chr2:120178261-120271930 (+)
CBA/J MGP_CBAJ_G0026010
protein coding gene Chr2:129492363-129590545 (+)
DBA/2J MGP_DBA2J_G0026149
protein coding gene Chr2:115578046-115664801 (+)
FVB/NJ MGP_FVBNJ_G0026111
protein coding gene Chr2:114406387-114492157 (+)
LP/J MGP_LPJ_G0026250
protein coding gene Chr2:121393202-121485109 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026130
protein coding gene Chr2:133871537-133959339 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026790
protein coding gene Chr2:119531966-119625703 (+)
PWK/PhJ MGP_PWKPhJ_G0025232
protein coding gene Chr2:115130939-115218646 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025031
protein coding gene Chr2:118697406-118784622 (+)
WSB/EiJ MGP_WSBEiJ_G0025565
protein coding gene Chr2:120355723-120446821 (+)



Homology
more
  • Human Ortholog
    EIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GCN2, PVOD2
  • Links
    NCBI Gene ID: 440275
    neXtProt AC: NX_Q9P2K8
    UniProt: Q9P2K8

  • Chr Location
    15q15.1; chr15:39934101-40035596 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 7 genetic backgrounds
    1 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele have altered feeding behavior, synaptic plasticity and dendritic cell function. Homozygotes for another null allele show enhanced muscle loss and morbidity after amino acid deprivation. Homozygotes for an ENU-induced allele show higher susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005102 Ensembl Gene Model | MGI Sequence Detail 86617 C57BL/6J ±  kb
    transcript ENSMUST00000005233 Ensembl | MGI Sequence Detail 5212 Not Applicable  
    polypeptide ENSMUSP00000005233 Ensembl | MGI Sequence Detail 1648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 66
      Primer pair 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 5
      Gene Ontology 22
      Phenotypes 58
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264586 Zimmermann HR, et al., Genetic removal of eIF2alpha kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity. J Neurochem. 2018 Jul;146(2):133-144

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory