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Eif2ak4 Gene Detail
Summary
  • Symbol
    Eif2ak4
  • Name
    eukaryotic translation initiation factor 2 alpha kinase 4
  • Synonyms
    GCN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353427
    NCBI Gene: 27103
  • Gene Overview
    MyGene.info: EIF2AK4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:118388618-118475234 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86617 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.40 cM, cytoband E5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCN2, PVOD2
  • Links
    NCBI Gene ID: 440275
    neXtProt AC: NX_Q9P2K8
    UniProt: Q9P2K8

  • Chr Location
    15q15.1; chr15:39934101-40035596 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 7 genetic backgrounds
    1 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele have altered feeding behavior, synaptic plasticity and dendritic cell function. Homozygotes for another null allele show enhanced muscle loss and morbidity after amino acid deprivation. Homozygotes for an ENU-induced allele show higher susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015229 VEGA Gene Model | MGI Sequence Detail 86617 C57BL/6J ±  kb
    transcript OTTMUST00000036076 VEGA | MGI Sequence Detail 5212 Not Applicable  
    polypeptide OTTMUSP00000016209 VEGA | MGI Sequence Detail 1648 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1012 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 66
      Primer pair 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 5
      Gene Ontology 21
      Phenotypes 58
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264586 Zimmermann HR, et al., Genetic removal of eIF2alpha kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity. J Neurochem. 2018 Jul;146(2):133-144

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory