About   Help   FAQ
Csnk1e Gene Detail
Summary
  • Symbol
    Csnk1e
  • Name
    casein kinase 1, epsilon
  • Synonyms
    CK1epsilon, CKIepsilon, CKI epsilon, KC1epsilon, tau
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351660
    NCBI Gene: 27373
Location & Maps
more
  • Sequence Map
    Chr15:79417856-79443919 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26064 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CSNK1E, casein kinase 1 epsilon
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CSNK1E, casein kinase 1 epsilon
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CKIepsilon, HCKIE
  • Links
    NCBI Gene ID: 1454
    neXtProt AC: NX_P49674

  • Chr Location
    22q13.1; chr22:38290691-38318084 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    65
  • Chemically induced (other)
    1
  • Gene trapped
    55
  • Radiation induced
    2
  • Targeted
    7
  • Genomic Mutations
    3 involving Csnk1e
  • Incidental Mutations
Mice homozygous for a null allele exhibit disruptions in circadian rhythms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029589 VEGA Gene Model | MGI Sequence Detail 26064 C57BL/6J ±  kb
transcript OTTMUST00000073380 VEGA | MGI Sequence Detail 2694 Not Applicable  
polypeptide OTTMUSP00000037966 VEGA | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    98 from dbSNP Build 137
  • PCR
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000005946 casein kinase I isoform epsilon
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 136
    cDNA 135
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2145998, MGI:2146039, MGI:2146216
References
more
  • Summaries
    All 68
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 18
    Phenotypes 36
  • Earliest
    J:59123 Kusuda J, et al., cDNA cloning and chromosome mapping of the mouse casein kinase I epsilon gene (Csnk1e). Cytogenet Cell Genet. 1999;87(1-2):99-101
  • Latest
    J:210023 Duong HA, et al., Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014 Feb;21(2):126-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory