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Csnk1e Gene Detail
Summary
  • Symbol
    Csnk1e
  • Name
    casein kinase 1, epsilon
  • Synonyms
    CK1epsilon, CKIepsilon, CKI epsilon, KC1epsilon, tau
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351660
    NCBI Gene: 27373
  • Gene Overview
    MyGene.info: CSNK1E
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79417856-79455566 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.71 cM, cytoband E1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351660
protein coding gene Chr15:79417852-79455579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022074
protein coding gene Chr15:79683609-79711769 (-)
A/J MGP_AJ_G0022035
protein coding gene Chr15:76939942-76965954 (-)
AKR/J MGP_AKRJ_G0022010
protein coding gene Chr15:79088542-79114559 (-)
BALB/cJ MGP_BALBcJ_G0022041
protein coding gene Chr15:76931241-76957981 (-)
C3H/HeJ MGP_C3HHeJ_G0021812
protein coding gene Chr15:79079018-79105044 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022484
protein coding gene Chr15:82836388-82864180 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020014
protein coding gene Chr15:73419707-73445888 (-)
CAST/EiJ MGP_CASTEiJ_G0021333
protein coding gene Chr15:79782054-79808582 (-)
CBA/J MGP_CBAJ_G0021777
protein coding gene Chr15:85405381-85435592 (-)
DBA/2J MGP_DBA2J_G0021906
protein coding gene Chr15:76420883-76447232 (-)
FVB/NJ MGP_FVBNJ_G0021884
protein coding gene Chr15:75452422-75478404 (-)
LP/J MGP_LPJ_G0021974
protein coding gene Chr15:79873224-79900478 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021904
protein coding gene Chr15:90517062-90543051 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022498
protein coding gene Chr15:79099715-79125928 (-)
PWK/PhJ MGP_PWKPhJ_G0021075
protein coding gene Chr15:76431817-76458655 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020912
protein coding gene Chr15:78916587-78943295 (-)
WSB/EiJ MGP_WSBEiJ_G0021385
protein coding gene Chr15:79483722-79511672 (-)



Homology
more
  • Human Ortholog
    CSNK1E, casein kinase 1 epsilon
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CSNK1E, casein kinase 1 epsilon
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CKIe, CKIepsilon, HCKIE
  • Links
    NCBI Gene ID: 1454
    neXtProt AC: NX_P49674
    UniProt: P49674

  • Chr Location
    22q13.1; chr22:38290691-38318084 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit disruptions in circadian rhythms.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022433 Ensembl Gene Model | MGI Sequence Detail 37711 C57BL/6J ±  kb
transcript ENSMUST00000117786 Ensembl | MGI Sequence Detail 2694 Not Applicable  
polypeptide ENSMUSP00000113341 Ensembl | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 137
    cDNA 136
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
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MGI:2145998, MGI:2146039, MGI:2146216
References
more
  • Summaries
    All 103
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 21
    Phenotypes 41
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:263009 Narasimamurthy R, et al., CK1delta/epsilon protein kinase primes the PER2 circadian phosphoswitch. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5986-5991

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory