Csnk1e MGI Mouse Gene Detail - MGI:1351660

Symbol

Csnk1e
Name

casein kinase 1, epsilon
Synonyms

CK1epsilon, CKIepsilon, CKI epsilon, KC1epsilon, tau

Feature Type

protein coding gene
IDs

MGI:1351660
NCBI Gene: 27373
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:79302056-79339767 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.71 cM, cytoband E1
Mapping Data

6 experiments

SNPs within 2kb

157 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351660	protein coding gene	Chr15:79302054-79339779 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022074	protein coding gene	Chr15:79683609-79711769 (-)
A/J	MGP_AJ_G0022035	protein coding gene	Chr15:76939942-76965954 (-)
AKR/J	MGP_AKRJ_G0022010	protein coding gene	Chr15:79088542-79114559 (-)
BALB/cJ	MGP_BALBcJ_G0022041	protein coding gene	Chr15:76931241-76957981 (-)
C3H/HeJ	MGP_C3HHeJ_G0021812	protein coding gene	Chr15:79079018-79105044 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022484	protein coding gene	Chr15:82836388-82864180 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020014	protein coding gene	Chr15:73419707-73445888 (-)
CAST/EiJ	MGP_CASTEiJ_G0021333	protein coding gene	Chr15:79782054-79808582 (-)
CBA/J	MGP_CBAJ_G0021777	protein coding gene	Chr15:85405381-85435592 (-)
DBA/2J	MGP_DBA2J_G0021906	protein coding gene	Chr15:76420883-76447232 (-)
FVB/NJ	MGP_FVBNJ_G0021884	protein coding gene	Chr15:75452422-75478404 (-)
LP/J	MGP_LPJ_G0021974	protein coding gene	Chr15:79873224-79900478 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021904	protein coding gene	Chr15:90517062-90543051 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022498	protein coding gene	Chr15:79099715-79125928 (-)
PWK/PhJ	MGP_PWKPhJ_G0021075	protein coding gene	Chr15:76431817-76458655 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020912	protein coding gene	Chr15:78916587-78943295 (-)
WSB/EiJ	MGP_WSBEiJ_G0021385	protein coding gene	Chr15:79483722-79511672 (-)

Human Ortholog

CSNK1E, casein kinase 1 epsilon

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSNK1E, casein kinase 1 epsilon
Synonyms

CKIe, CKIepsilon, HCKIE
Links

HGNC:2453

NCBI Gene ID: 1454

neXtProt AC: NX_P49674

UniProt: P49674
Chr Location

22q13.1; chr22:38290691-38318084 (-) GRCh38

Human Ortholog

TPTEP2-CSNK1E, TPTEP2-CSNK1E readthrough
Synonyms

LOC400927-CSNK1E
Links

HGNC:53829

NCBI Gene ID: 102800317

neXtProt AC: NX_P49674
Chr Location

22q13.1; chr22:38290691-38398915 (-) GRCh38

MGI Vertebrate Homology

Csnk1e stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CSNK1E, TPTEP2-CSNK1E
Gene Tree

Csnk1e

Diseases

1 with human CSNK1E associations

				Human Disease	Mouse Models
				invasive ductal carcinoma IDs invasive ductal carcinoma DOID:3008 DOID:3005 MESH:D018270 NCI:C4017 NCI:C4194 UMLS_CUI:C1134719 UMLS_CUI:C1527349

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 3 alleles in 2 genetic backgrounds
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

68
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

55
Radiation induced

2
Targeted

7
Genomic Mutations

3 involving Csnk1e
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

Mice homozygous for a null allele exhibit disruptions in circadian rhythms.

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All GO Annotations

44
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

995
Tissues

183
cDNA Data

135
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase csnk1e

ZFIN csnk1e

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All Sequences

130
RefSeq

60
UniProt

10
CCDS

CCDS27640.1, CCDS70646.1

Ensembl

ENSMUSG00000022433 (Evidence)
NCBI Gene

27373

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022433	Ensembl Gene Model \| MGI Sequence Detail	37712	C57BL/6J	± kb
transcript	ENSMUST00000117786	Ensembl \| MGI Sequence Detail	2695	Not Applicable
polypeptide	ENSMUSP00000113341	Ensembl \| MGI Sequence Detail	416	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000005946 casein kinase I isoform epsilon

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 137

cDNA 136

Primer pair 1

Microarray probesets 8

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MGI:2145998, MGI:2146039, MGI:2146216

Summaries

All 119

Developmental Gene Expression 10

Diseases 1

Gene Ontology 22

Phenotypes 53
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:308263 Maywood ES, et al., Circadian Chimeric Mice Reveal an Interplay Between the Suprachiasmatic Nucleus and Local Brain Clocks in the Control of Sleep and Memory. Front Neurosci. 2021;15:639281

TSS for Csnk1e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135349	Chr15:79339729-79339761 (-)	22 bp
Tssr135348	Chr15:79326311-79326325 (-)	13,449 bp
Tssr135347	Chr15:79326273-79326307 (-)	13,477 bp
Tssr135346	Chr15:79326210-79326266 (-)	13,529 bp
Tssr135345	Chr15:79326002-79326060 (-)	13,736 bp
Tssr135344	Chr15:79314054-79314059 (-)	25,710 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23