Csnk1e
Gene Detail

Symbol Name ID

Csnk1e casein kinase 1, epsilon MGI:1351660

Synonyms

CK1epsilon, CKIepsilon, CKI epsilon, KC1epsilon, tau

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.71 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:79417856-79443919 bp, - strand From VEGA annotation of GRCm38   26064 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:121695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Csnk1e

Human homologs

Human Homolog		CSNK1E, casein kinase 1, epsilon
NCBI Gene ID		1454
neXtProt AC		NX_P49674
Human Synonyms		CKIepsilon, HCKIE
Human Chr (Location)		22q13.1; chr22:38686697-38714089 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(62) : Targeted(7) Gene trapped(55)
 

Mice homozygous for a null allele exhibit disruptions in circadian rhythms.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cellular protein localization, circadian rhythm, ...
Component	cytoplasm, nucleus, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (281)    Tissues (177)    Images (42)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	277
Western blot	4

cDNA source data(136)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(138) cDNA(137) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000029589 (Evidence)
Ensembl Gene Model	ENSMUSG00000022433 (Evidence)
Entrez Gene	27373 (Evidence)
UniGene	30199
DFCI	TC1575357, TC1615175, TC1685811
DoTS	DT.55100184, DT.55220996, DT.91391696
NIA Mouse Gene Index	U036405
EC	2.7.11.1
Consensus CDS Project	CCDS27640.1
International Mouse Knockout Project Status	Csnk1e

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029589	VEGA Gene Model | MGI Sequence Detail	26064	C57BL/6J
transcript	OTTMUST00000073380	VEGA | MGI Sequence Detail	2694	Not Applicable
polypeptide	OTTMUSP00000037966	VEGA | MGI Sequence Detail	416	Not Applicable

All sequences(70) RefSeq(2) UniProt(7)

Polymorphisms

PCR(1) : SNPs(58 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005946	casein kinase I isoform epsilon

References

(Earliest) J:59123 Kusuda J, et al., cDNA cloning and chromosome mapping of the mouse casein kinase I epsilon gene (Csnk1e). Cytogenet Cell Genet. 1999;87(1-2):99-101
(Latest) J:177139 Lee HM, et al., The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16451-6
All references(63)

Other accession IDs

MGI:2145998, MGI:2146039, MGI:2146216