G3bp1
Gene Detail

Symbol Name ID

G3bp1 GTPase activating protein (SH3 domain) binding protein 1 MGI:1351465

Synonyms

GAP SH3 binding protein

Feature Type

protein coding gene

Genetic Map

Chromosome 11

33.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:55469685-55504838 bp, + strand From VEGA annotation of GRCm38   35154 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38096  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: G3bp1

Human homologs

Human Homolog		G3BP1, GTPase activating protein (SH3 domain) binding protein 1
NCBI Gene ID		10146
neXtProt AC		NX_Q13283
Human Synonyms		G3BP, HDH-VIII
Human Chr (Location)		5q33.1; chr5:151151476-151184915 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(63) : Targeted(3) Gene trapped(60)
 

Homozygous null mice display perinatal lethality with severe cell death in the nervous system and decreased cell proliferation. Neonates from heterozygous null female mice display increased mortality.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	negative regulation of canonical Wnt receptor signaling pathway, transport
Component	cytoplasm, cytoplasmic stress granule, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (132)    Tissues (128)    Images (21)
Theiler Stages: 11, 13, 21, 22, 24, 26, 28

Assay Type	Results
RNA in situ	130
RT-PCR	2

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000005694 (Evidence)
Ensembl Gene Model	ENSMUSG00000018583 (Evidence)
Entrez Gene	27041 (Evidence)
DFCI	TC1577633, TC1605827, TC1704944, TC1723995
DoTS	DT.103572791, DT.110544488, DT.110876383, DT.494015, DT.55209254
NIA Mouse Gene Index	U012634, U022335, U064641, U304233, U305152, U331873, U345793
EC	3.6.4.12, 3.6.4.13
Consensus CDS Project	CCDS24714.1
International Mouse Knockout Project Status	G3bp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005694	VEGA Gene Model | MGI Sequence Detail	35154	C57BL/6J
transcript	OTTMUST00000012673	VEGA | MGI Sequence Detail	6703	Not Applicable
polypeptide	OTTMUSP00000005871	VEGA | MGI Sequence Detail	465	Not Applicable

All sequences(52) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002075	Nuclear transport factor 2
InterPro	IPR018222	Nuclear transport factor 2, Eukaryote
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000007743	ras GTPase-activating protein-binding protein 1

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:183055 Bikkavilli RK, et al., Arginine methylation of G3BP1 in response to Wnt3a regulates beta-catenin mRNA. J Cell Sci. 2011 Jul 1;124(Pt 13):2310-20
All references(43)

Other accession IDs

MGI:2144303, MGI:2144694