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G3bp1
Gene Detail
 Symbol
Name
ID
G3bp1
GTPase activating protein (SH3 domain) binding protein 1
MGI:1351465
Synonyms GAP SH3 binding protein
Feature Type protein coding gene
Genetic Map
Chromosome 11
33.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:55469685-55504838 bp, + strand
From VEGA annotation of GRCm38

  35154 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38096  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: G3bp1

Human
homologs
Human Homolog G3BP1, GTPase activating protein (SH3 domain) binding protein 1
NCBI Gene ID 10146
neXtProt AC  NX_Q13283
Human Synonyms  G3BP, HDH-VIII
Human Chr (Location)  5q33.1; chr5:151771915-151811352 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(60) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display perinatal lethality with severe cell death in the nervous system and decreased cell proliferation. Neonates from heterozygous null female mice display increased mortality.
 
Interactions
G3bp1 interacts with 407 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process negative regulation of canonical Wnt signaling pathway, transport
Component cytoplasm, cytoplasmic stress granule, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (132)    Tissues (129)    Images (21)
Theiler Stages: 11, 13, 21, 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 130
RT-PCR 2
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005694 (Evidence)
Ensembl Gene ModelENSMUSG00000018583 (Evidence)
Entrez Gene27041 (Evidence)
DFCITC1577633, TC1605827, TC1704944, TC1723995
DoTSDT.103572791, DT.110544488, DT.110876383, DT.494015, DT.55209254
NIA Mouse Gene IndexU012634, U022335, U064641, U304233, U305152, U331873, U345793
EC3.6.4.12, 3.6.4.13
Consensus CDS ProjectCCDS24714.1
International Mouse Knockout Project StatusG3bp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005694 VEGA Gene Model | MGI Sequence Detail 35154 C57BL/6J ±  kb
transcript OTTMUST00000012673 VEGA | MGI Sequence Detail 6703 Not Applicable 
polypeptide OTTMUSP00000005871 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002075 Nuclear transport factor 2
InterPro IPR018222 Nuclear transport factor 2, Eukaryote
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000007743 ras GTPase-activating protein-binding protein 1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(48)
Other
accession IDs
MGI:2144303, MGI:2144694

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory