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Mecr
Gene Detail
Symbol

Name
ID
Mecr
mitochondrial trans-2-enoyl-CoA reductase
MGI:1349441
Synonyms
Nrbf1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
64.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:131843470-131867786 bp, + strand
From VEGA annotation of GRCm38

  24317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5362  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MECR
Protein SuperFamily: alcohol dehydrogenase
Gene Tree: Mecr

Human
homologs
MECR, mitochondrial trans-2-enoyl-CoA reductase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51102
neXtProt AC: NX_Q9BV79

Human Synonyms: CGI-63, FASN2B, NRBF1

Human Chr (Location): 1p35.3; chr1:29167696-29230958 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Genomic Mutations involving Mecr (1)
Incidental mutations (data from APF )
Interactions
Mecr interacts with 23 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process fatty acid biosynthetic process, fatty acid metabolic process, ...
Component cytosol, mitochondrion, ...
Function ligand-dependent nuclear receptor binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mecr ; ZFIN mecr    NEW 
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009566 (Evidence)
Ensembl Gene Model ENSMUSG00000028910 (Evidence)
Entrez Gene 26922 (Evidence)
UniGene 192706
DFCI TC1609053, TC1673536, TC1578236
DoTS DT.55100211, DT.94208679, DT.94251092
NIA Mouse Gene Index U004893
EC 1.3.1.38
Consensus CDS Project CCDS18715.1
International Mouse Phenotyping Consortium Status Mecr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009566 VEGA Gene Model | MGI Sequence Detail 24317 C57BL/6J ±  kb
transcript OTTMUST00000021919 VEGA | MGI Sequence Detail 1337 Not Applicable 
polypeptide OTTMUSP00000009996 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(21) UniProt(2)
Polymorphisms
SNPs within 2kb(248 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013149 Alcohol dehydrogenase, C-terminal
InterPro IPR013154 Alcohol dehydrogenase GroES-like
InterPro IPR002085 Alcohol dehydrogenase superfamily, zinc-type
InterPro IPR011032 GroES-like
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000010278 trans-2-enoyl-CoA reductase, mitochondrial
References
(Earliest) J:50854 Masuda N, et al., Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Gene. 1998 Oct 23;221(2):225-33
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:2140207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory