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Mecr Gene Detail
Summary
  • Symbol
    Mecr
  • Name
    mitochondrial trans-2-enoyl-CoA reductase
  • Synonyms
    Nrbf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349441
    NCBI Gene: 26922
  • Gene Overview
    MyGene.info: MECR
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:131843470-131867786 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 64.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349441
protein coding gene Chr4:131843443-131867787 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028858
protein coding gene Chr4:133949455-133980161 (+)
A/J MGP_AJ_G0028817
protein coding gene Chr4:128387978-128412105 (+)
AKR/J MGP_AKRJ_G0028770
protein coding gene Chr4:131981422-132010037 (+)
BALB/cJ MGP_BALBcJ_G0028840
protein coding gene Chr4:129002600-129027172 (+)
C3H/HeJ MGP_C3HHeJ_G0028554
protein coding gene Chr4:132236157-132261209 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029282
protein coding gene Chr4:138768274-138794742 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026554
protein coding gene Chr4:121482212-121508439 (+)
CAST/EiJ MGP_CASTEiJ_G0027987
protein coding gene Chr4:130298935-130327114 (+)
CBA/J MGP_CBAJ_G0028520
protein coding gene Chr4:142312153-142336149 (+)
DBA/2J MGP_DBA2J_G0028669
protein coding gene Chr4:128812407-128837148 (+)
FVB/NJ MGP_FVBNJ_G0028636
protein coding gene Chr4:127660184-127688581 (+)
LP/J MGP_LPJ_G0028770
protein coding gene Chr4:134106104-134137354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028662
protein coding gene Chr4:146957109-146982930 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029320
protein coding gene Chr4:132376067-132402297 (+)
PWK/PhJ MGP_PWKPhJ_G0027708
protein coding gene Chr4:125481578-125506773 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027534
protein coding gene Chr4:128260691-128291407 (+)
WSB/EiJ MGP_WSBEiJ_G0028067
protein coding gene Chr4:132552768-132582804 (+)



Homology
more
  • Human Ortholog
    MECR, mitochondrial trans-2-enoyl-CoA reductase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MECR, mitochondrial trans-2-enoyl-CoA reductase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-63, DYTOABG, ETR1, FASN2B, NRBF1
  • Links
    NCBI Gene ID: 51102
    neXtProt AC: NX_Q9BV79
    UniProt: Q9BV79

  • Chr Location
    1p35.3; chr1:29192657-29230958 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    4 involving Mecr
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028910 Ensembl Gene Model | MGI Sequence Detail 24317 C57BL/6J ±  kb
transcript ENSMUST00000030742 Ensembl | MGI Sequence Detail 1337 Not Applicable  
polypeptide ENSMUSP00000030742 Ensembl | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    cDNA 58

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140207
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:50854 Masuda N, et al., Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Gene. 1998 Oct 23;221(2):225-33
  • Latest
    J:242847 Nair RR, et al., Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Hum Mol Genet. 2017 Jun 01;26(11):2104-2117

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory