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Abcd3
Gene Detail
Symbol

Name
ID
Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
MGI:1349216
Synonyms
PMP70, Pxmp1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
52.94 cM, cytoband G-H1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:121758910-121815215 bp, - strand
From Ensembl annotation of GRCm38

  56306 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2140  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABCD3
Gene Tree: Abcd3

Human
homologs
ABCD3, ATP-binding cassette, sub-family D (ALD), member 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5825
neXtProt AC: NX_P28288

Human Synonyms: ABC43, CBAS5, PMP70, PXMP1, ZWS2

Human Chr (Location): 1p21.3; chr1:94418086-94518663 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ABCD3

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Abcd3 interacts with 216 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (114)    Tissues (108)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 17
Western blot 3
cDNA source data(211)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase abcd3 ; ZFIN abcd3a    NEW 
Molecular
reagents
All nucleic(213) Genomic(1) cDNA(212)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000028127 (Evidence)
Entrez Gene 19299 (Evidence)
UniGene 399042
DFCI TC1572115, TC1718386
DoTS DT.91379141, DT.535809
NIA Mouse Gene Index U024595
Consensus CDS Project CCDS17806.1
International Mouse Phenotyping Consortium Status Abcd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028127 Ensembl Gene Model | MGI Sequence Detail 56306 C57BL/6J ±  kb
transcript ENSMUST00000029770 Ensembl | MGI Sequence Detail 3399 Not Applicable 
polypeptide ENSMUSP00000029770 Ensembl | MGI Sequence Detail 659 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(739 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR005283 Peroxysomal long chain fatty acyl transporter
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003567 ATP-binding cassette sub-family D member 3
References
(Earliest) J:4078 Gartner J, et al., Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3. Genomics. 1993 Feb;15(2):412-4
(Latest) J:182961 Kaczmarek K, et al., Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice. Mol Biol Cell. 2011 May 15;22(10):1766-79
All references(51)
Other
accession IDs
MGD-MRK-13699, MGI:2139661, MGI:2139875, MGI:2139974, MGI:97826

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory