About   Help   FAQ
Cul3
Gene Detail
Symbol

Name
ID
Cul3
cullin 3
MGI:1347360
Feature Type
protein coding gene
Genetic Map
Chromosome 1
41.24 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:80264923-80340480 bp, - strand
From VEGA annotation of GRCm38

  75558 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cullin
Gene Tree: Cul3

Human
homologs
Human Homolog CUL3, cullin 3
NCBI Gene ID 8452
neXtProt AC  NX_Q13618
Human Synonyms  CUL-3, PHA2E
Human Chr (Location)  2q36.2; chr2:224470150-224585397 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CUL3
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(32) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation accumulate cyclin E, exhibit abnormal cycling in cells of extraembryonic ectoderm and trophectoderm, reduced size, abnormal gastrulation and trophoblast cells, absence of an amnion, and death by embryonic day 7.5.
 
Interactions
Cul3 interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process cell migration, cell morphogenesis, ...
Component Cul3-RING ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, ...
Function cyclin binding, POZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Western blot 9
cDNA source data(199)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(199) cDNA(199)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000035349 (Evidence)
Ensembl Gene ModelENSMUSG00000004364 (Evidence)
Entrez Gene26554 (Evidence)
UniGene12665
DFCITC1620610, TC1574055
DoTSDT.535615, DT.101170077
NIA Mouse Gene IndexU043832
PDB1IUY
Consensus CDS ProjectCCDS15094.1
International Mouse Knockout Project StatusCul3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035349 VEGA Gene Model | MGI Sequence Detail 75558 C57BL/6J ±  kb
transcript OTTMUST00000090232 VEGA | MGI Sequence Detail 4709 Not Applicable 
polypeptide OTTMUSP00000049459 VEGA | MGI Sequence Detail 768 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(11)
Polymorphisms
SNPs within 2kb(390 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016157 Cullin, conserved site
InterPro IPR016158 Cullin homology
InterPro IPR001373 Cullin, N-terminal
InterPro IPR019559 Cullin protein, neddylation domain
InterPro IPR016159 Cullin repeat-like-containing domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006048 cullin-3
References
(Earliest) J:57761 Singer JD, et al., Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 1999 Sep 15;13(18):2375-87
(Latest) J:214293 Mathew R, et al., A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation. J Exp Med. 2014 Jun 2;211(6):1137-51
All references(51)
Other
accession IDs
MGI:2138270, MGI:2138569

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory