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Cul3 Gene Detail
Summary
  • Symbol
    Cul3
  • Name
    cullin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347360
    NCBI Gene: 26554
Location & Maps
more
  • Sequence Map
    Chr1:80264923-80340480 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75558 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CUL3, cullin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CUL3, cullin 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CUL-3, PHA2E
  • Links
    NCBI Gene ID: 8452
    neXtProt AC: NX_Q13618

  • Chr Location
    2q36.2; chr2:224470150-224585397 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2661
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CUL3
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CUL3 associations

Human Disease Mouse Models
       Pseudohypoaldosteronism, Type Iie; PHA2E   OMIM: 614496
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    40
  • Chemically induced (other)
    1
  • Gene trapped
    32
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Cul3
  • Incidental Mutations
Homozygotes for a targeted null mutation accumulate cyclin E, exhibit abnormal cycling in cells of extraembryonic ectoderm and trophectoderm, reduced size, abnormal gastrulation and trophoblast cells, absence of an amnion, and death by embryonic day 7.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035349 VEGA Gene Model | MGI Sequence Detail 75558 C57BL/6J ±  kb
transcript OTTMUST00000090232 VEGA | MGI Sequence Detail 4709 Not Applicable  
polypeptide OTTMUSP00000049459 VEGA | MGI Sequence Detail 768 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    390 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
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  • All nucleic 199
    cDNA 199

    Microarray probesets 7
Other
Accession IDs
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MGI:2138270, MGI:2138569
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 13
    Phenotypes 18
  • Earliest
    J:57761 Singer JD, et al., Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 1999 Sep 15;13(18):2375-87
  • Latest
    J:226618 Araki Y, et al., Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene. Biol Open. 2015;4(11):1509-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory