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Cul3 Gene Detail
Summary
  • Symbol
    Cul3
  • Name
    cullin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347360
    NCBI Gene: 26554
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:80242640-80318197 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 41.24 cM, cytoband C4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    389 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347360
 protein coding gene Chr1:80242640-80318407 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016210
 protein coding gene Chr1:81076097-81155573 (-)
A/J MGP_AJ_G0016193
 protein coding gene Chr1:78213844-78290054 (-)
AKR/J MGP_AKRJ_G0016150
 protein coding gene Chr1:80354792-80432550 (-)
BALB/cJ MGP_BALBcJ_G0016148
 protein coding gene Chr1:78296662-78373895 (-)
C3H/HeJ MGP_C3HHeJ_G0015978
 protein coding gene Chr1:80701140-80777230 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016601
 protein coding gene Chr1:84225283-84302136 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014321
 protein coding gene Chr1:73532296-73605406 (-)
CAST/EiJ MGP_CASTEiJ_G0015563
 protein coding gene Chr1:80069089-80149751 (-)
CBA/J MGP_CBAJ_G0015952
 protein coding gene Chr1:86904247-86983547 (-)
DBA/2J MGP_DBA2J_G0016053
 protein coding gene Chr1:77521897-77598001 (-)
FVB/NJ MGP_FVBNJ_G0016056
 protein coding gene Chr1:76661254-76737219 (-)
LP/J MGP_LPJ_G0016126
 protein coding gene Chr1:82221059-82299668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016076
 protein coding gene Chr1:90168448-90271264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016648
 protein coding gene Chr1:80469656-80552406 (-)
PWK/PhJ MGP_PWKPhJ_G0015349
 protein coding gene Chr1:76931748-77008296 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015127
 protein coding gene Chr1:79742543-79822538 (-)
WSB/EiJ MGP_WSBEiJ_G0015624
 protein coding gene Chr1:80245879-80324778 (-)



Homology
more
  • Human Ortholog
    CUL3, cullin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CUL3, cullin 3
  • Synonyms
    CUL-3, NEDAUS, PHA2E
  • Links
    NCBI Gene ID: 8452
    neXtProt AC: NX_Q13618
    UniProt: Q13618

  • Chr Location
    2q36.2; chr2:224470150-224585397 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CUL3 associations

Human Disease Mouse Models
      
IDs
 View 2 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 7 alleles in 8 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation accumulate cyclin E, exhibit abnormal cycling in cells of extraembryonic ectoderm and trophectoderm, reduced size, abnormal gastrulation and trophoblast cells, absence of an amnion, and death by embryonic day 7.5. Conditional heterozygous KO in neuronal cells causes social deficits and anxiety-like behavior, while homozygous neuronal KO leads to brain abnormalities, small body size and death before weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    112
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    17
  • cDNA Data
    200
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004364 Ensembl Gene Model | MGI Sequence Detail 75558 C57BL/6J ±  kb
    transcript ENSMUST00000163119 Ensembl | MGI Sequence Detail 4709 Not Applicable  
    polypeptide ENSMUSP00000130738 Ensembl | MGI Sequence Detail 768 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 200
      cDNA 200

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138270, MGI:2138569
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 19
      Phenotypes 35
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:332862 Rapanelli M, et al., Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits. Transl Psychiatry. 2023 Jan 24;13(1):22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory