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Rpl27a Gene Detail
Summary
  • Symbol
    Rpl27a
  • Name
    ribosomal protein L27A
  • Synonyms
    L27', L27A, ribosomal protein L29 homolog (yeast)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347076
    NCBI Gene: 26451
  • Gene Overview
    MyGene.info: RPL27A
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109519195-109522369 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.26 cM, cytoband E2-F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347076
protein coding gene Chr7:109519147-109522369 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032842
protein coding gene Chr7:112947539-112950766 (+)
A/J MGP_AJ_G0032826
protein coding gene Chr7:110160794-110164827 (+)
AKR/J MGP_AKRJ_G0032757
protein coding gene Chr7:112927225-112931901 (+)
BALB/cJ MGP_BALBcJ_G0032830
protein coding gene Chr7:109857902-109861119 (+)
C3H/HeJ MGP_C3HHeJ_G0032540
protein coding gene Chr7:112956641-112959860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033336
protein coding gene Chr7:117632609-117637244 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030309
protein coding gene Chr7:111732170-111735309 (+)
CAST/EiJ MGP_CASTEiJ_G0031868
protein coding gene Chr7:104484301-104487518 (+)
CBA/J MGP_CBAJ_G0032513
protein coding gene Chr7:121492122-121497925 (+)
DBA/2J MGP_DBA2J_G0032665
protein coding gene Chr7:108271982-108275244 (+)
FVB/NJ MGP_FVBNJ_G0032618
protein coding gene Chr7:108119429-108122622 (+)
LP/J MGP_LPJ_G0032759
protein coding gene Chr7:114477923-114481187 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032650
protein coding gene Chr7:123150961-123154185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033357
protein coding gene Chr7:111933762-111937409 (+)
PWK/PhJ MGP_PWKPhJ_G0031575
protein coding gene Chr7:101069750-101073161 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031423
protein coding gene Chr7:98620499-98623760 (+)
WSB/EiJ MGP_WSBEiJ_G0031981
protein coding gene Chr7:112776651-112781684 (+)



Homology
more
  • Human Ortholog
    RPL27A, ribosomal protein L27a
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPL27A, ribosomal protein L27a
    Orthology source: HomoloGene, HGNC
  • Synonyms
    L27A
  • Links
    NCBI Gene ID: 6157
    neXtProt AC: NX_P46776
    UniProt: P46776

  • Chr Location
    11p15.4; chr11:8682448-8689872 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for an ENU-induced allele die before E7.5. Heterozygotes show partial postnatal lethality, retarded growth, cerebellar ataxia, small cerebella, spleens and thymi, hyperpigmentation of the tail, feet, ears and genital areas, pancytopenia, anemia, and high sensitivity to gamma-irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26451 NCBI Gene Model | MGI Sequence Detail 3175 C57BL/6J ±  kb
    transcript NM_011975 RefSeq | MGI Sequence Detail 1112 C57BL/6  
    polypeptide P14115 UniProt | EBI | MGI Sequence Detail 148 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 430
      Genomic 2
      cDNA 428

      Microarray probesets 14
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:8614 Belhumeur P, et al., Isolation and characterisation of a murine cDNA clone highly homologous to the yeast L29 ribosomal protein gene. Nucleic Acids Res. 1987 Feb 11;15(3):1019-29
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory