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Rpl27a Gene Detail
Summary
  • Symbol
    Rpl27a
  • Name
    ribosomal protein L27A
  • Synonyms
    L27', L27A, ribosomal protein L29 homolog (yeast)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347076
    NCBI Gene: 26451
  • Gene Overview
    MyGene.info: RPL27A
Location & Maps
more
  • Sequence Map
    Chr7:109519147-109522367 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3221 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.26 cM, cytoband E2-F1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RPL27A, ribosomal protein L27a
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPL27A, ribosomal protein L27a
    Orthology source: HGNC, HomoloGene
  • Synonyms
    L27A
  • Links
    NCBI Gene ID: 6157
    neXtProt AC: NX_P46776

  • Chr Location
    11p15; chr11:8682448-8689872 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    46
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    38
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Rpl27a
  • Incidental Mutations
    APF
Homozygotes for an ENU-induced allele die before E7.5. Heterozygotes show partial postnatal lethality, retarded growth, cerebellar ataxia, small cerebella, spleens and thymi, hyperpigmentation of the tail, feet, ears and genital areas, pancytopenia, anemia, and high sensitivity to gamma-irradiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022787 VEGA Gene Model | MGI Sequence Detail 3221 C57BL/6J ±  kb
transcript OTTMUST00000054734 VEGA | MGI Sequence Detail 1158 Not Applicable  
polypeptide OTTMUSP00000026153 VEGA | MGI Sequence Detail 148 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014209 60S ribosomal protein L27a
  • InterPro Domains
    IPR030878 Ribosomal protein L15
    IPR001196 Ribosomal protein L15, conserved site
    IPR021131 Ribosomal protein L18e/L15P
Molecular
Reagents
less
  • All nucleic 429
    Genomic 2
    cDNA 427

    Microarray probesets 14
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:8614 Belhumeur P, et al., Isolation and characterisation of a murine cDNA clone highly homologous to the yeast L29 ribosomal protein gene. Nucleic Acids Res. 1987 Feb 11;15(3):1019-29
  • Latest
    J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory