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Map2k4
Gene Detail
 Symbol
Name
ID
Map2k4
mitogen-activated protein kinase kinase 4
MGI:1346869
Synonyms JNKK1, MKK4, Sek1, Serk1
Feature Type protein coding gene
Genetic Map
Chromosome 11
40.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:65688243-65788297 bp, - strand
From VEGA annotation of GRCm38

  100055 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k4

Human
homologs
Human Homolog MAP2K4, mitogen-activated protein kinase kinase 4
NCBI Gene ID 6416
neXtProt AC  NX_P45985
Human Synonyms  JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK1, SAPKK-1, SEK1, SERK1, SKK1
Human Chr (Location)  17p12; chr17:12020818-12143831 (+)  GRCh38
Alleles
and
phenotypes
All alleles(18) : Gene trapped(11) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit abnormal liver development with a deficiency of parenchymal hepatocytes, severe anemia, and lethality before embryonic day 14.0.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process activation of JUN kinase activity, apoptotic process, ...
Component axon, cytoplasm, ...
Function ATP binding, JUN kinase kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (205)    Tissues (141)    Images (50)
Theiler Stages: 13, 15, 17, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 179
Northern blot 8
Western blot 12
cDNA source data(109)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(111) cDNA(110) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005905 (Evidence)
Ensembl Gene ModelENSMUSG00000033352 (Evidence)
Entrez Gene26398 (Evidence)
UniGene412922
DFCITC1574808, TC1697938
DoTSDT.101137806, DT.110527622, DT.99857880
NIA Mouse Gene IndexU032926
EC2.7.12.2
Consensus CDS ProjectCCDS24844.1
International Mouse Knockout Project StatusMap2k4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005905 VEGA Gene Model | MGI Sequence Detail 100055 C57BL/6J ±  kb
transcript OTTMUST00000013146 VEGA | MGI Sequence Detail 3695 Not Applicable 
polypeptide OTTMUSP00000006102 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(14) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(492 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003283 dual specificity mitogen-activated protein kinase kinase 4
References (Earliest) J:35302 Sanchez I, et al., Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994 Dec 22-29;372(6508):794-8
(Latest) J:186492 Hubner A, et al., JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12046-51
All references(75)
Other
accession IDs
MGD-MRK-35660, MGI:107199

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory