Map2k4
Gene Detail

Symbol Name ID

Map2k4 mitogen-activated protein kinase kinase 4 MGI:1346869

Synonyms

JNKK1, MKK4, Sek1, Serk1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

40.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr11:65688243-65788297 bp, - strand From VEGA annotation of GRCm38   100055 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k4

Human homologs

Human Homolog		MAP2K4, mitogen-activated protein kinase kinase 4
NCBI Gene ID		6416
neXtProt AC		NX_P45985
Human Synonyms		JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK1, SAPKK-1, SEK1, SERK1
Human Chr (Location)		17p12; chr17:11924135-12047051 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(7) Gene trapped(11)
 

Homozygotes for targeted null mutations exhibit abnormal liver development with a deficiency of parenchymal hepatocytes, severe anemia, and lethality before embryonic day 14.0.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	activation of JUN kinase activity, apoptotic process, ...
Component	axon part, cytoplasm, ...
Function	ATP binding, JUN kinase kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (205)    Tissues (141)    Images (49)
Theiler Stages: 13, 15, 17, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	179
Northern blot	8
Western blot	12

cDNA source data(108)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(110) cDNA(109) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005905 (Evidence)
Ensembl Gene Model	ENSMUSG00000033352 (Evidence)
Entrez Gene	26398 (Evidence)
UniGene	412922
DFCI	TC1574808, TC1697938
DoTS	DT.101137806, DT.110527622, DT.99857880
NIA Mouse Gene Index	U032926
EC	2.7.12.2
Consensus CDS Project	CCDS24844.1
International Mouse Knockout Project Status	Map2k4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005905	VEGA Gene Model | MGI Sequence Detail	100055	C57BL/6J
transcript	OTTMUST00000013146	VEGA | MGI Sequence Detail	3695	Not Applicable
polypeptide	OTTMUSP00000006102	VEGA | MGI Sequence Detail	397	Not Applicable

All sequences(42) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(309 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003283	dual specificity mitogen-activated protein kinase kinase 4

References

(Earliest) J:35302 Sanchez I, et al., Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994 Dec 22-29;372(6508):794-8
(Latest) J:186492 Hubner A, et al., JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12046-51
All references(75)

Other accession IDs

MGD-MRK-35660, MGI:107199