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Psmc4
Gene Detail
Symbol

Name
ID
Psmc4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
MGI:1346093
Synonyms
CAR interacting protein 21, CIP21, MIP224
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:28041707-28050101 bp, - strand
From VEGA annotation of GRCm38

  8395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ATP-dependent 26S proteinase
Gene Tree: Psmc4

Human
homologs
Human Homolog PSMC4, proteasome (prosome, macropain) 26S subunit, ATPase, 4
NCBI Gene ID 5704
neXtProt AC  NX_P43686
Human Synonyms  MIP224, RPT3, S6, TBP7, TBP-7
Human Chr (Location)  19q13.11-q13.13; chr19:39971005-39981764 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(10) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos. Mice heterozygous for a knock-out allele and a conditional allele activated in motor neurons develop ALS-like symptoms.
 
Phenotype Images(3)
Interactions
Psmc4 interacts with 17 markers (Mir16-2, Mir325, Mir450-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process blastocyst development, protein catabolic process
Component cytoplasm, cytosolic proteasome complex, ...
Function ATP binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (101)    Tissues (28)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 74
Northern blot 6
RT-PCR 13
cDNA source data(168)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(172) cDNA(168) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025054 (Evidence)
Ensembl Gene ModelENSMUSG00000030603 (Evidence)
Entrez Gene23996 (Evidence)
UniGene29582
DFCITC1596953, TC1572136
DoTSDT.60198242, DT.94235112, DT.94234981, DT.99856844
NIA Mouse Gene IndexU107477
PDB3AJI
Consensus CDS ProjectCCDS21034.1
International Mouse Knockout Project StatusPsmc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025054 VEGA Gene Model | MGI Sequence Detail 8395 C57BL/6J ±  kb
transcript OTTMUST00000061646 VEGA | MGI Sequence Detail 1440 Not Applicable 
polypeptide OTTMUSP00000030278 VEGA | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(2) UniProt(15)
Polymorphisms
RFLP(1) : SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005937 26S proteasome subunit P45
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000013382 26S protease regulatory subunit 6B
References
(Earliest) J:57555 Choi HS, et al., A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):23-30
(Latest) J:193770 Tashiro Y, et al., Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem. 2012 Dec 14;287(51):42984-94
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory