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Amfr
Gene Detail
 Symbol
Name
ID
Amfr
autocrine motility factor receptor
MGI:1345634
Synonyms gp78
Feature Type protein coding gene
Genetic Map
Chromosome 8
45.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:93971588-94012663 bp, - strand
From VEGA annotation of GRCm38

  41076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: conserved protein with RING finger and CUE domain, autocrine motility factor receptor type
Gene Tree: Amfr

Human
homologs
Human Homolog AMFR, autocrine motility factor receptor, E3 ubiquitin protein ligase
NCBI Gene ID 267
neXtProt AC  NX_Q9UKV5
Human Synonyms  GP78, RNF45
Human Chr (Location)  16q21; chr16:56361452-56425538 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal HMGCR turnover in mouse embryonic fibroblasts.
 
Interactions
Amfr interacts with 214 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cellular process, endoplasmic reticulum unfolded protein response, ...
Component cytoplasm, dendrite, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (84)    Tissues (40)    Images (52)
Theiler Stages: 1, 2, 3, 5, 23, 24, 27, 28
Assay TypeResults
RNA in situ 77
RT-PCR 7
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(10) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027363 (Evidence)
Ensembl Gene ModelENSMUSG00000031751 (Evidence)
Entrez Gene23802 (Evidence)
DFCITC1572308, TC1642388, TC1781382
DoTSDT.101345053, DT.101394998, DT.535205, DT.94228903, DT.94228908, DT.97360634
NIA Mouse Gene IndexU030114
EC6.3.2.-
Consensus CDS ProjectCCDS22533.1
International Mouse Knockout Project StatusAmfr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027363 VEGA Gene Model | MGI Sequence Detail 41076 C57BL/6J ±  kb
transcript OTTMUST00000067661 VEGA | MGI Sequence Detail 3701 Not Applicable 
polypeptide OTTMUSP00000034082 VEGA | MGI Sequence Detail 639 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(2) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003892 Ubiquitin system component Cue
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000004568 E3 ubiquitin-protein ligase AMFR
References (Earliest) J:56927 Shimizu K, et al., The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 1999 Aug 6;456(2):295-300
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory