About   Help   FAQ
Gmcl1 Gene Detail
Summary
  • Symbol
    Gmcl1
  • Name
    germ cell-less, spermatogenesis associated 1
  • Synonyms
    2810049L19Rik, Btbd13, Gcl, mglc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345156
    NCBI Gene: 23885
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86691768-86733383 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.75 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345156
protein coding gene Chr6:86691768-86733399 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030982
protein coding gene Chr6:88000662-88044289 (-)
A/J MGP_AJ_G0030948
protein coding gene Chr6:84598537-84639880 (-)
AKR/J MGP_AKRJ_G0030879
protein coding gene Chr6:87046072-87089412 (-)
BALB/cJ MGP_BALBcJ_G0030961
protein coding gene Chr6:84609465-84651390 (-)
C3H/HeJ MGP_C3HHeJ_G0030749
protein coding gene Chr6:97376698-97418164 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031418
protein coding gene Chr6:90379382-90422197 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028602
protein coding gene Chr6:82781407-82823280 (-)
CAST/EiJ MGP_CASTEiJ_G0030070
protein coding gene Chr6:87117126-87159707 (-)
CBA/J MGP_CBAJ_G0030645
protein coding gene Chr6:93933743-93983133 (-)
DBA/2J MGP_DBA2J_G0030801
protein coding gene Chr6:83916160-83958142 (-)
FVB/NJ MGP_FVBNJ_G0030754
protein coding gene Chr6:83099428-83143030 (-)
LP/J MGP_LPJ_G0030878
protein coding gene Chr6:88032094-88074856 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030787
protein coding gene Chr6:98052417-98096097 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031445
protein coding gene Chr6:86885028-86929338 (-)
PWK/PhJ MGP_PWKPhJ_G0029785
protein coding gene Chr6:82857403-82902415 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029613
protein coding gene Chr6:85725845-85768801 (-)
WSB/EiJ MGP_WSBEiJ_G0030151
protein coding gene Chr6:87350656-87393487 (-)



Homology
more
  • Human Ortholog
    GMCL1, germ cell-less, spermatogenesis associated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GMCL1, germ cell-less, spermatogenesis associated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTBD13, GCL, GCL1, SPATA29
  • Links
    NCBI Gene ID: 64395
    neXtProt AC: NX_Q96IK5
    UniProt: Q96IK5

  • Chr Location
    2p13.3; chr2:69829606-69881396 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8021
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GMCL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired nuclear membrane integrity in liver, endocrine pancreas, and testis. Mutant males show reduced fertility with decreased chromatin condensation and morphologically abnormal sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001157 Ensembl Gene Model | MGI Sequence Detail 41616 C57BL/6J ±  kb
    transcript ENSMUST00000001185 Ensembl | MGI Sequence Detail 2949 Not Applicable  
    polypeptide ENSMUSP00000001185 Ensembl | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 66
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919974
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:57109 Kimura T, et al., Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells. Biochem Biophys Res Commun. 1999 Aug 19;262(1):223-30
    • Latest
      J:156017 Yokoyama S, et al., A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory