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Capn10
Gene Detail
 Symbol
Name
ID
Capn10
calpain 10
MGI:1344392
Synonyms Capn8, mKIAA1845
Feature Type protein coding gene
Genetic Map
Chromosome 1
46.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:92934376-92947941 bp, + strand
From VEGA annotation of GRCm38

  13566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Capn10

Human
homologs
Human Homolog CAPN10, calpain 10
NCBI Gene ID 11132
neXtProt AC  NX_Q9HC96
Human Synonyms  CANP10, NIDDM1
Human Chr (Location)  2q37.3; chr2:240586716-240599109 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CAPN10
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit resistance to ryanodine- and palmitate-induced pancreatic apoptosis. Mice homozygous for a different knock-out allele exhibit increased adiposity, body and organ weights, and leptin serum levels on background containing LG/J.
 
Interactions
Capn10 interacts with 109 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process actin cytoskeleton reorganization, aging, ...
Component cell, cell cortex, ...
Function calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (2)    Images (9)
Theiler Stages: 23
Assay TypeResults
RNA in situ 12
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(66)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000026368 (Evidence)
Ensembl Gene ModelENSMUSG00000026270 (Evidence)
Entrez Gene23830 (Evidence)
UniGene294315
DoTSDT.101377511, DT.528914, DT.97415484, DT.97415487
EC3.4.22.-
Consensus CDS ProjectCCDS15181.1
International Mouse Knockout Project StatusCapn10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026368 VEGA Gene Model | MGI Sequence Detail 13566 C57BL/6J ±  kb
transcript OTTMUST00000065210 VEGA | MGI Sequence Detail 2902 Not Applicable 
polypeptide OTTMUSP00000032463 VEGA | MGI Sequence Detail 666 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR001300 Peptidase C2, calpain, catalytic domain
InterPro IPR022683 Peptidase C2, calpain, domain III
InterPro IPR022684 Peptidase C2, calpain family
InterPro IPR022682 Peptidase C2, calpain, large subunit, domain III
Protein Ontology PR:000005010 calpain-10
References (Earliest) J:56364 Braun C, et al., CAPN 8: isolation of a new mouse calpain-isoenzyme. Biochem Biophys Res Commun. 1999 Jul 14;260(3):671-5
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGI:2138550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory