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Capn10 Gene Detail
Summary
  • Symbol
    Capn10
  • Name
    calpain 10
  • Synonyms
    Capn8, mKIAA1845
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344392
    NCBI Gene: 23830
  • Gene Overview
    MyGene.info: CAPN10
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:92934408-92947948 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 46.60 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344392
protein coding gene Chr1:92934376-92947948 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016330
protein coding gene Chr1:94542780-94556292 (+)
A/J MGP_AJ_G0016311
protein coding gene Chr1:91154362-91167893 (+)
AKR/J MGP_AKRJ_G0016272
protein coding gene Chr1:93844133-93859552 (+)
BALB/cJ MGP_BALBcJ_G0016267
protein coding gene Chr1:91324945-91338521 (+)
C3H/HeJ MGP_C3HHeJ_G0016096
protein coding gene Chr1:94094782-94109391 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016726
protein coding gene Chr1:98136855-98150364 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014444
protein coding gene Chr1:85402811-85416358 (+)
CAST/EiJ MGP_CASTEiJ_G0015679
protein coding gene Chr1:93420045-93434563 (+)
CBA/J MGP_CBAJ_G0016070
protein coding gene Chr1:101308542-101330209 (+)
DBA/2J MGP_DBA2J_G0016175
protein coding gene Chr1:90351083-90364658 (+)
FVB/NJ MGP_FVBNJ_G0016174
protein coding gene Chr1:89421470-89435010 (+)
LP/J MGP_LPJ_G0016246
protein coding gene Chr1:95723208-95736714 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016199
protein coding gene Chr1:104440252-104453832 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016765
protein coding gene Chr1:93868017-93881579 (+)
PWK/PhJ MGP_PWKPhJ_G0015464
protein coding gene Chr1:89784894-89798465 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015248
protein coding gene Chr1:92805714-92819259 (+)
WSB/EiJ MGP_WSBEiJ_G0015739
protein coding gene Chr1:93672730-93690689 (+)



Homology
more
  • Human Ortholog
    CAPN10, calpain 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CAPN10, calpain 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CANP10, NIDDM1
  • Links
    NCBI Gene ID: 11132
    neXtProt AC: NX_Q9HC96
    UniProt: Q9HC96

  • Chr Location
    2q37.3; chr2:240586716-240599109 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 36323
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CAPN10
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CAPN10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to ryanodine- and palmitate-induced pancreatic apoptosis. Mice homozygous for a different knock-out allele exhibit increased adiposity, body and organ weights, and leptin serum levels on background containing LG/J.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23830 NCBI Gene Model | MGI Sequence Detail 13541 C57BL/6J ±  kb
    transcript NM_011796 RefSeq | MGI Sequence Detail 2877 FVB/N  
    polypeptide Q9ESK3 UniProt | EBI | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 67

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138550
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory