Capn10
Gene Detail

Symbol Name ID

Capn10 calpain 10 MGI:1344392

Synonyms

Capn8, mKIAA1845

Feature Type

protein coding gene

Genetic Map

Chromosome 1

46.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:92934376-92947941 bp, + strand From VEGA annotation of GRCm38   13566 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36323  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Capn10

Human homologs

Human Homolog		CAPN10, calpain 10
NCBI Gene ID		11132
neXtProt AC		NX_Q9HC96
Human Synonyms		CANP10, NIDDM1
Human Chr (Location)		2q37.3; chr2:241526133-241538526 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CAPN10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit resistance to ryanodine- and palmitate-induced pancreatic apoptosis. Mice homozygous for a different knock-out allele exhibit increased adiposity, body and organ weights, and leptin serum levels on background containing LG/J.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	actin cytoskeleton reorganization, cellular response to insulin stimulus, ...
Component	cell, intracellular
Function	calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (2)    Images (9)
Theiler Stages: 23

Assay Type	Results
RNA in situ	12

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000026368 (Evidence)
Ensembl Gene Model	ENSMUSG00000026270 (Evidence)
Entrez Gene	23830 (Evidence)
DoTS	DT.101377511, DT.528914, DT.97415484, DT.97415487
EC	3.4.22.-
Consensus CDS Project	CCDS15181.1
International Mouse Knockout Project Status	Capn10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026368	VEGA Gene Model | MGI Sequence Detail	13566	C57BL/6J
transcript	OTTMUST00000065210	VEGA | MGI Sequence Detail	2902	Not Applicable
polypeptide	OTTMUSP00000032463	VEGA | MGI Sequence Detail	666	Not Applicable

All sequences(44) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(176 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000169	Cysteine peptidase, cysteine active site
InterPro	IPR001300	Peptidase C2, calpain, catalytic domain
InterPro	IPR022683	Peptidase C2, calpain, domain III
InterPro	IPR022684	Peptidase C2, calpain family
InterPro	IPR022682	Peptidase C2, calpain, large subunit, domain III
Protein Ontology	PR:000005010	calpain-10

References

(Earliest) J:56364 Braun C, et al., CAPN 8: isolation of a new mouse calpain-isoenzyme. Biochem Biophys Res Commun. 1999 Jul 14;260(3):671-5
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)

Other accession IDs

MGI:2138550