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Prkra
Gene Detail
Symbol

Name
ID
Prkra
protein kinase, interferon inducible double stranded RNA dependent activator
MGI:1344375
Synonyms
lear, Pact, PRK, RAX
Feature Type
protein coding gene
Genetic Map
Chromosome 2
45.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:76629898-76648015 bp, - strand
From VEGA annotation of GRCm38

  18118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2738  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Prkra

Human
homologs
Human Homolog PRKRA, protein kinase, interferon-inducible double stranded RNA dependent activator
NCBI Gene ID 8575
neXtProt AC  NX_O75569
Human Synonyms  DYT16, PACT, RAX
Human Chr (Location)  2q31.2; chr2:178431414-178451231 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRKRA
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Spontaneous(2) Targeted(4)
Genomic Mutations involving Prkra (2)
Incidental mutations (data from APF )
 
Homozygotes of one targeted or either of two spontaneous mutations display reduced size of the pinna and external auditory canal, abnormal middle ear morphology, increased auditory thresholds, and reduced body size, while a null allele results in complete embryonic lethality
 
Human Diseases Modeled Using Mouse Prkra (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Prkra interacts with 135 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to oxidative stress, gene silencing by RNA, ...
Component cytoplasm, intracellular, ...
Function poly(A) RNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (66)    Tissues (28)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
RT-PCR 38
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(52) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013128 (Evidence)
Ensembl Gene ModelENSMUSG00000002731 (Evidence)
Entrez Gene23992 (Evidence)
UniGene277250
DFCITC1578106, TC1622391, TC1756181
DoTSDT.101317568, DT.532077, DT.91422413, DT.94337973
NIA Mouse Gene IndexU022772
Consensus CDS ProjectCCDS16159.1
International Mouse Knockout Project StatusPrkra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013128 VEGA Gene Model | MGI Sequence Detail 18118 C57BL/6J ±  kb
transcript OTTMUST00000031689 VEGA | MGI Sequence Detail 1614 Not Applicable 
polypeptide OTTMUSP00000014121 VEGA | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014720 Double-stranded RNA-binding-like domain
Protein Ontology PR:000013241 interferon-inducible double-stranded RNA-dependent protein kinase activator A
References
(Earliest) J:55431 Ito T, et al., RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. J Biol Chem. 1999 May 28;274(22):15427-32
(Latest) J:197985 Ota H, et al., ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89
All references(45)
Disease annotation references (1)
Other
accession IDs
MGI:2139255, MGI:4439143

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory