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Prkra Gene Detail
Summary
  • Symbol
    Prkra
  • Name
    protein kinase, interferon inducible double stranded RNA dependent activator
  • Synonyms
    lear, Pact, PRK, RAX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344375
    NCBI Gene: 23992
  • Gene Overview
    MyGene.info: PRKRA
Location & Maps
more
  • Sequence Map
    Chr2:76629898-76648015 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18118 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 45.07 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRKRA, protein activator of interferon induced protein kinase EIF2AK2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKRA, protein activator of interferon induced protein kinase EIF2AK2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DYT16, HSD14, PACT, RAX
  • Links
    NCBI Gene ID: 8575
    neXtProt AC: NX_O75569

  • Chr Location
    2q31.2; chr2:178431414-178451231 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2738
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PRKRA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Prkra mouse models; 1 with human PRKRA associations

Human Disease Mouse Models
       Microtia-Anotia   OMIM: 600674 View 1 model
       Dystonia 16; DYT16   OMIM: 612067
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 6 alleles in 7 genetic backgrounds
    11 phenotypes from multigenic genotypes
    4 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Spontaneous
    4
  • Targeted
    4
  • Genomic Mutations
    3 involving Prkra
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013128 VEGA Gene Model | MGI Sequence Detail 18118 C57BL/6J ±  kb
transcript OTTMUST00000031689 VEGA | MGI Sequence Detail 1614 Not Applicable  
polypeptide OTTMUSP00000014121 VEGA | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    120 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013241 interferon-inducible double-stranded RNA-dependent protein kinase activator A
  • InterPro Domains
    IPR014720 Double-stranded RNA-binding domain
    IPR033363 Interferon-inducible double-stranded RNA-dependent protein kinase activator A
    IPR032478 Staufen, C-terminal
Molecular
Reagents
less
  • All nucleic 54
    cDNA 52
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139255, MGI:4439143
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:55431 Ito T, et al., RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. J Biol Chem. 1999 May 28;274(22):15427-32
  • Latest
    J:223062 Palmer K, et al., Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol. 2015 Jul 30;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory