Rorb
Gene Detail

Symbol Name ID

Rorb RAR-related orphan receptor beta MGI:1343464

Synonyms

MGC:38728, Nr1f2, Rorbeta, RZR-beta

Feature Type

protein coding gene

Genetic Map

Chromosome 19

13.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:18930605-19111196 bp, - strand From VEGA annotation of GRCm38   180592 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rorb

Human homologs

Human Homolog		RORB, RAR-related orphan receptor B
NCBI Gene ID		6096
Human Synonyms		bA133M9.1, NR1F2, ROR-BETA, RZRB, RZR-BETA
Human Chr (Location)		9q22; chr9:74497336-74687201 (+)  GRCh38

Alleles and phenotypes

All alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	amacrine cell differentiation, cellular response to retinoic acid, ...
Component	nucleus
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (85 records)

Data Summary: Results (410)    Tissues (208)    Images (84)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	410

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000023329 (Evidence)
Ensembl Gene Model	ENSMUSG00000036192 (Evidence)
Entrez Gene	225998 (Evidence)
DFCI	TC1584159, TC1593293, TC1612629, TC1612902, TC1615227, TC1644312, TC1653244, TC1711899
DoTS	DT.101143401, DT.55274616, DT.87026020, DT.94034108, DT.94256609, DT.99843682, DT.99855591
NIA Mouse Gene Index	U038900
Consensus CDS Project	CCDS37932.1, CCDS37933.1
International Mouse Knockout Project Status	Rorb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023329	VEGA Gene Model | MGI Sequence Detail	180592	C57BL/6J
transcript	OTTMUST00000056531	VEGA | MGI Sequence Detail	8759	Not Applicable
polypeptide	OTTMUSP00000027181	VEGA | MGI Sequence Detail	470	Not Applicable

All sequences(58) RefSeq(6) UniProt(1)

Polymorphisms

SNPs within 2kb(1289 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR003079	Nuclear receptor ROR
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000014164	nuclear receptor ROR-beta

References

(Earliest) J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
(Latest) J:205743 Liu H, et al., An isoform of retinoid-related orphan receptor beta directs differentiation of retinal amacrine and horizontal interneurons. Nat Commun. 2013;4:1813
All references(121)