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Rorb
Gene Detail
Symbol

Name
ID
Rorb
RAR-related orphan receptor beta
MGI:1343464
Synonyms
MGC:38728, Nr1f2, Rorbeta, RZR-beta
Feature Type
protein coding gene
Genetic Map
Chromosome 19
13.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:18930605-19111196 bp, - strand
From VEGA annotation of GRCm38

  180592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RORB
Gene Tree: Rorb

Human
homologs
RORB, RAR-related orphan receptor B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6096

Human Synonyms: bA133M9.1, NR1F2, ROR-BETA, RZRB, RZR-BETA

Human Chr (Location): 9q22; chr9:74497336-74687201 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.
 
Interactions
Rorb interacts with 546 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (93 records)
Data Summary: Results (422)    Tissues (218)    Images (96)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 422
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100491456, rorb ; ZFIN rorb    NEW 
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000023329 (Evidence)
Ensembl Gene Model ENSMUSG00000036192 (Evidence)
Entrez Gene 225998 (Evidence)
DFCI TC1711899, TC1653244, TC1644312, TC1612902, TC1612629, TC1615227, TC1584159, TC1593293
DoTS DT.99855591, DT.55274616, DT.101143401, DT.94256609, DT.99843682, DT.87026020, DT.94034108
NIA Mouse Gene Index U038900
Consensus CDS Project CCDS37932.1, CCDS37933.1
International Mouse Phenotyping Consortium Status Rorb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023329 VEGA Gene Model | MGI Sequence Detail 180592 C57BL/6J ±  kb
transcript OTTMUST00000056531 VEGA | MGI Sequence Detail 8759 Not Applicable 
polypeptide OTTMUSP00000027181 VEGA | MGI Sequence Detail 470 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(1289 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003079 Nuclear receptor ROR
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000014164 nuclear receptor ROR-beta
References
(Earliest) J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
(Latest) J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76
All references(127)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory