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Rorb Gene Detail
Summary
  • Symbol
    Rorb
  • Name
    RAR-related orphan receptor beta
  • Synonyms
    hstp, MGC:38728, Nr1f2, Rorbeta, RZR-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343464
    NCBI Gene: 225998
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:18930605-19111196 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      180592 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.28 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RORB, RAR related orphan receptor B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RORB, RAR related orphan receptor B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA133M9.1, NR1F2, ROR-BETA, RZRB, RZR-BETA
  • Links
    NCBI Gene ID: 6096
    UniProt: Q92753

  • Chr Location
    9q21.13; chr9:74497336-74687201 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 38250
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RORB
  • Gene Tree
    Rorb
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 8 alleles in 8 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    475
  • Tissues
    244
  • cDNA Data
    14
  • Literature Summary
    111
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023329 VEGA Gene Model | MGI Sequence Detail 180592 C57BL/6J ±  kb
    transcript OTTMUST00000056531 VEGA | MGI Sequence Detail 8759 Not Applicable  
    polypeptide OTTMUSP00000027181 VEGA | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1289 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3838140
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 111
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
    • Latest
      J:254118 De Clercq S, et al., DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation. Cereb Cortex. 2018 Feb 1;28(2):493-509
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory