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Rorb Gene Detail
Summary
  • Symbol
    Rorb
  • Name
    RAR-related orphan receptor beta
  • Synonyms
    hstp, MGC:38728, Nr1f2, Rorbeta, RZR-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343464
    NCBI Gene: 225998
Location & Maps
more
  • Sequence Map
    Chr19:18930605-19111196 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      180592 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.28 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RORB, RAR related orphan receptor B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RORB, RAR related orphan receptor B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA133M9.1, NR1F2, ROR-BETA, RZRB, RZR-BETA
  • Links
    NCBI Gene ID: 6096

  • Chr Location
    9q22; chr9:74497336-74687201 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 38250
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RORB
  • Gene Tree
    Rorb
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 6 alleles in 6 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    2
  • Spontaneous
    1
  • Targeted
    8
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    460
  • Tissues
    239
  • cDNA Data
    14
  • Literature Summary
    99
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023329 VEGA Gene Model | MGI Sequence Detail 180592 C57BL/6J ±  kb
transcript OTTMUST00000056531 VEGA | MGI Sequence Detail 8759 Not Applicable  
polypeptide OTTMUSP00000027181 VEGA | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1289 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014164 nuclear receptor ROR-beta
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003079 Nuclear receptor ROR
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
less
  • All nucleic 18
    cDNA 16
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:3838140
References
more
  • Summaries
    All 136
    Developmental Gene Expression 99
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
  • Latest
    J:234341 Fame RM, et al., Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity. J Neurosci. 2016 Jun 15;36(24):6403-19
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory