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Rorb Gene Detail
Summary
  • Symbol
    Rorb
  • Name
    RAR-related orphan receptor beta
  • Synonyms
    hstp, MGC:38728, Nr1f2, Rorbeta, RZR-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343464
    NCBI Gene: 225998
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:18930605-19111196 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      180592 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.28 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RORB, RAR related orphan receptor B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RORB, RAR related orphan receptor B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA133M9.1, NR1F2, ROR-BETA, RZRB, RZR-BETA
  • Links
    NCBI Gene ID: 6096
    UniProt: Q92753

  • Chr Location
    9q21.13; chr9:74497336-74687201 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 38250
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RORB
  • Gene Tree
    Rorb
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 8 alleles in 8 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    504
  • Tissues
    253
  • cDNA Data
    16
  • Literature Summary
    113
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023329 VEGA Gene Model | MGI Sequence Detail 180592 C57BL/6J ±  kb
    transcript OTTMUST00000056531 VEGA | MGI Sequence Detail 8759 Not Applicable  
    polypeptide OTTMUSP00000027181 VEGA | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1289 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 18
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3838140
    References
    more
    • Summaries
      All 158
      Developmental Gene Expression 113
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
    • Latest
      J:263835 Newman EA, et al., Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Jul 15;439(2):102-111
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/18/2018
    MGI 6.12     		The Jackson Laboratory