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Rorb Gene Detail
Summary
  • Symbol
    Rorb
  • Name
    RAR-related orphan receptor beta
  • Synonyms
    hstp, MGC:38728, Nr1f2, Rorbeta, RZR-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343464
    NCBI Gene: 225998
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:18907969-19088560 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5072 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343464
 protein coding gene Chr19:18907966-19088560 (-)
129S1/SvImJ ENSMUSG00200020148
 protein coding gene Chr19:15587989-15768665 (-)
A/J ENSMUSG00195016321
 protein coding gene Chr19:15743004-15930536 (-)
AKR/J ENSMUSG00220010476
 protein coding gene Chr19:15719833-15900465 (-)
BALB/cJ ENSMUSG00180018428
 protein coding gene Chr19:16107219-16287865 (-)
C3H/HeJ ENSMUSG00175003373
 protein coding gene Chr19:15451259-15638781 (-)
C57BL/6NJ ENSMUSG00215014502
 protein coding gene Chr19:15514345-15694995 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022808
 protein coding gene Chr19:16253187-16433068 (-)
CAST/EiJ ENSTCUG00005008423
 protein coding gene Chr19:15363696-15545475 (-)
CBA/J ENSMUSG00210012802
 protein coding gene Chr19:15685812-15873329 (-)
DBA/2J ENSMUSG00185013070
 protein coding gene Chr19:16102628-16283342 (-)
FVB/NJ ENSMUSG00205003768
 protein coding gene Chr19:15511934-15692565 (-)
JF1/MsJ ENSUMUG00000017768
 protein coding gene Chr19:16351281-16531880 (-)
LP/J ENSMUSG00230016651
 protein coding gene Chr19:16957160-17137833 (-)
NOD/ShiLtJ ENSMUSG00190018675
 protein coding gene Chr19:15466444-15647114 (-)
NZO/HlLtJ ENSMUSG00225033652
 protein coding gene Chr19:20720600-20901077 (-)
PWK/PhJ ENSLUMG00010008447
 protein coding gene Chr19:15677994-15858697 (-)
SPRET/EiJ ENSMSPG00010018300
 protein coding gene Chr19:15674619-15864016 (-)
WSB/EiJ ENSIUOG00005007146
 protein coding gene Chr19:15195390-15376045 (-)



Homology
more
  • Human Ortholog
    RORB, RAR related orphan receptor B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RORB, RAR related orphan receptor B
  • Synonyms
    bA133M9.1, EIG15, NR1F2, RORbeta, ROR-BETA, RZRB, RZR-BETA
  • Links
    NCBI Gene ID: 6096
    UniProt: Q92753

  • Chr Location
    9q21.13; chr9:74497335-74693177 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 11 alleles in 12 genetic backgrounds
    2 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1308
  • Tissues
    323
  • cDNA Data
    17
  • Literature Summary
    167
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036192 Ensembl Gene Model | MGI Sequence Detail 180592 C57BL/6J ±  kb
    transcript ENSMUST00000040153 Ensembl | MGI Sequence Detail 8759 Not Applicable  
    polypeptide ENSMUSP00000047597 Ensembl | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014164 nuclear receptor ROR-beta
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003079 Nuclear receptor ROR
      IPR044101 Retinoid-related orphan receptors, DNA-binding domain
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    • GlyGen
      Q8R1B8 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 24
      Primer pair 8
      Other 11
      Antibodies 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3838140
    References
    more
    • Summaries
      All 271
      Developmental Gene Expression 167
      Gene Ontology 16
      Phenotypes 73
    • Earliest
      J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
    • Latest
      J:389923 Muchamedin A, et al., Pbx1 and Pbx3 cooperatively regulate intermediate progenitor genesis and corticogenesis in the mouse neocortex. Front Cell Dev Biol. 2026;14:1809251
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory