Rorb MGI Mouse Gene Detail - MGI:1343464 - RAR-related orphan receptor beta

Rorb Gene Detail

Symbol

Rorb
Name

RAR-related orphan receptor beta
Synonyms

hstp, MGC:38728, Nr1f2, Rorbeta, RZR-beta

Feature Type

protein coding gene
IDs

MGI:1343464
NCBI Gene: 225998

Sequence Map

Chr19:18930605-19111196 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

180592 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 13.28 cM
Mapping Data

4 experiments

Human Ortholog

RORB, RAR related orphan receptor B

Vertebrate Orthologs

10

Human Ortholog

RORB, RAR related orphan receptor B
Orthology source: HomoloGene, HGNC
Synonyms

bA133M9.1, NR1F2, ROR-BETA, RZRB, RZR-BETA
Links

HGNC:10259

NCBI Gene ID: 6096

UniProt: Q92753
Chr Location

9q21.13; chr9:74497336-74687201 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 38250
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RORB
Gene Tree

Rorb

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Phenotype Summary

31 phenotypes from 6 alleles in 6 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (ENU)

2
Spontaneous

1
Targeted

10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.

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All GO Annotations

35
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

475
Tissues

244
cDNA Data

14
Literature Summary

104

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rorb, rorb.2

ZFIN rorb

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Rorb interacts with 546 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS37932.1, CCDS37933.1, CCDS79697.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023329	VEGA Gene Model \| MGI Sequence Detail	180592	C57BL/6J	± kb
transcript	OTTMUST00000056531	VEGA \| MGI Sequence Detail	8759	Not Applicable
polypeptide	OTTMUSP00000027181	VEGA \| MGI Sequence Detail	470	Not Applicable

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SNPs within 2kb

1289 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000014164 nuclear receptor ROR-beta

(term hierarchy)
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR003079 Nuclear receptor ROR

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 6

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MGI:3838140

Summaries

All 142

Developmental Gene Expression 104

Gene Ontology 9

Phenotypes 17
Earliest

J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
Latest

J:241099 Flore G, et al., Cortical Development Requires Mesodermal Expression of Tbx1, a Gene Haploinsufficient in 22q11.2 Deletion Syndrome. Cereb Cortex. 2017 Mar 01;27(3):2210-2225

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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