Rorb MGI Mouse Gene Detail - MGI:1343464 - RAR-related orphan receptor beta

Symbol

Rorb
Name

RAR-related orphan receptor beta
Synonyms

hstp, MGC:38728, Nr1f2, Rorbeta, RZR-beta

Feature Type

protein coding gene
IDs

MGI:1343464
NCBI Gene: 225998
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:18930609-19111196 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 13.28 cM
Mapping Data

4 experiments

SNPs within 2kb

1289 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1343464	protein coding gene	Chr19:18930605-19111196 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024971	protein coding gene	Chr19:16825977-17010353 (-)
A/J	MGP_AJ_G0024948	protein coding gene	Chr19:15877560-16064842 (-)
AKR/J	MGP_AKRJ_G0024918	protein coding gene	Chr19:16506258-16686010 (-)
BALB/cJ	MGP_BALBcJ_G0024947	protein coding gene	Chr19:15907787-16087443 (-)
C3H/HeJ	MGP_C3HHeJ_G0024705	protein coding gene	Chr19:16454030-16643665 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025389	protein coding gene	Chr19:17423137-17604833 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022808	protein coding gene	Chr19:16253187-16433068 (-)
CAST/EiJ	MGP_CASTEiJ_G0024173	protein coding gene	Chr19:16100128-16290005 (-)
CBA/J	MGP_CBAJ_G0024683	protein coding gene	Chr19:18074314-18273468 (-)
DBA/2J	MGP_DBA2J_G0024815	protein coding gene	Chr19:15908372-16089147 (-)
FVB/NJ	MGP_FVBNJ_G0024776	protein coding gene	Chr19:15814507-15995700 (-)
LP/J	MGP_LPJ_G0024899	protein coding gene	Chr19:16791325-16976091 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024803	protein coding gene	Chr19:17935660-18129699 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025444	protein coding gene	Chr19:16452066-16635929 (-)
PWK/PhJ	MGP_PWKPhJ_G0023922	protein coding gene	Chr19:15444259-15644585 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023727	protein coding gene	Chr19:15722878-15954021 (-)
WSB/EiJ	MGP_WSBEiJ_G0024241	protein coding gene	Chr19:16503561-16692599 (-)

Human Ortholog

RORB, RAR related orphan receptor B

Vertebrate Orthologs

10

Human Ortholog

RORB, RAR related orphan receptor B
Orthology source: HomoloGene, HGNC
Synonyms

bA133M9.1, NR1F2, ROR-BETA, RZRB, RZR-BETA
Links

HGNC:10259

NCBI Gene ID: 6096

UniProt: Q92753
Chr Location

9q21.13; chr9:74497336-74687201 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 38250
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RORB
Gene Tree

Rorb

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Phenotype Summary

40 phenotypes from 8 alleles in 8 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

3
Spontaneous

1
Targeted

12
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.

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All GO Annotations

34
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

504
Tissues

253
cDNA Data

16
Literature Summary

113

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rorb, rorb.2

ZFIN rorb

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Rorb interacts with 546 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

53
RefSeq

6
UniProt

2
CCDS

CCDS37932.1, CCDS37933.1, CCDS79697.1

Ensembl

ENSMUSG00000036192 (Evidence)
NCBI Gene

225998

			Length	Strain/Species	Flank
genomic	225998	NCBI Gene Model \| MGI Sequence Detail	180588	C57BL/6J	± kb
transcript	NM_001043354	RefSeq \| MGI Sequence Detail	9289	C57BL/6
polypeptide	Q8R1B8	UniProt \| EBI \| MGI Sequence Detail	470	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014164 nuclear receptor ROR-beta

(term hierarchy)
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR003079 Nuclear receptor ROR

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 21

cDNA 18

Primer pair 2

Other 1

Microarray probesets 6

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MGI:3838140

Summaries

All 158

Developmental Gene Expression 113

Gene Ontology 11

Phenotypes 23
Earliest

J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
Latest

J:263835 Newman EA, et al., Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Jul 15;439(2):102-111

TSS for Rorb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158544	Chr19:19111207-19111221 (-)	-18 bp
Tssr158543	Chr19:19111181-19111203 (-)	4 bp
Tssr158542	Chr19:19110939-19110950 (-)	251 bp
Tssr158532	Chr19:19001148-19001151 (-)	110,046 bp
Tssr158531	Chr19:19001099-19001119 (-)	110,087 bp
Tssr158530	Chr19:19001070-19001075 (-)	110,123 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/06/2018 MGI 6.13