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Gene Detail
RAR-related orphan receptor beta
Synonyms MGC:38728, Nr1f2, Rorbeta, RZR-beta
Feature Type protein coding gene
Genetic Map
Chromosome 19
13.28 cM
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr19:18930605-19111196 bp, - strand
From VEGA annotation of GRCm38

  180592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:38250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rorb

Human Homolog RORB, RAR-related orphan receptor B
NCBI Gene ID 6096
Human Synonyms  bA133M9.1, NR1F2, ROR-BETA, RZRB, RZR-BETA
Human Chr (Location)  9q22; chr9:74497336-74687201 (+)  GRCh38
alleles, and
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for disruptions in this gene have impaired vision and a variety of behavioral abnormalities.
Rorb interacts with 547 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (33 annotations)
Process amacrine cell differentiation, cellular response to retinoic acid, ...
Component nucleus
Function DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...
External Resources: FuncBase
Literature Summary: (86 records)
Data Summary: Results (410)    Tissues (217)    Images (84)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 410
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000023329 (Evidence)
Ensembl Gene ModelENSMUSG00000036192 (Evidence)
Entrez Gene225998 (Evidence)
DFCITC1584159, TC1593293, TC1612629, TC1612902, TC1615227, TC1644312, TC1653244, TC1711899
DoTSDT.101143401, DT.55274616, DT.87026020, DT.94034108, DT.94256609, DT.99843682, DT.99855591
NIA Mouse Gene IndexU038900
Consensus CDS ProjectCCDS37932.1, CCDS37933.1
International Mouse Knockout Project StatusRorb
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023329 VEGA Gene Model | MGI Sequence Detail 180592 C57BL/6J ±  kb
transcript OTTMUST00000056531 VEGA | MGI Sequence Detail 8759 Not Applicable 
polypeptide OTTMUSP00000027181 VEGA | MGI Sequence Detail 470 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(1289 from dbSNP Build 137)
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003079 Nuclear receptor ROR
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000014164 nuclear receptor ROR-beta
References (Earliest) J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
(Latest) J:208651 Louvi A, et al., Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development. 2014 Mar;141(6):1404-15
All references(122)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory