Mad1l1
Gene Detail

Symbol Name ID

Mad1l1 MAD1 mitotic arrest deficient 1-like 1 MGI:1341857

Synonyms

Mad1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

78.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:140008689-140321552 bp, - strand From VEGA annotation of GRCm38   312864 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74500  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mad1l1

Human homologs

Human Homolog		MAD1L1, MAD1 mitotic arrest deficient-like 1 (yeast)
NCBI Gene ID		8379
neXtProt AC		NX_Q9Y6D9
Human Synonyms		MAD1, PIG9, TP53I9, TXBP181
Human Chr (Location)		7p22; chr7:1855428-2272583 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAD1L1

Alleles and phenotypes

All alleles(63) : Targeted(4) Gene trapped(59)
 

Mice homozygous for a null allele die in utero. Aging heterozygous null mice show increased tumor incidence while heterozygous MEFs are more prone to aneuploidy, induce fibrosarcomas in athymic nude mice, and show a weaker spindle assembly checkpoint-mediated arrest n response to nocodazole.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cell cycle, cell division, ...
Component	actin cytoskeleton, chromosome, ...

External Resources: FuncBase

Expression

cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) cDNA(58)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030671 (Evidence)
Ensembl Gene Model	ENSMUSG00000029554 (Evidence)
Entrez Gene	17120 (Evidence)
UniGene	27250
DFCI	TC1580541, TC1608448
DoTS	DT.101350032, DT.101377704, DT.534780, DT.91326706, DT.97362009
NIA Mouse Gene Index	U128546
Consensus CDS Project	CCDS19817.1
International Mouse Knockout Project Status	Mad1l1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030671	VEGA Gene Model | MGI Sequence Detail	312864	C57BL/6J
transcript	OTTMUST00000075923	VEGA | MGI Sequence Detail	2640	Not Applicable
polypeptide	OTTMUSP00000039890	VEGA | MGI Sequence Detail	717	Not Applicable

All sequences(44) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008672	Mitotic checkpoint
Protein Ontology	PR:000010037	mitotic spindle assembly checkpoint protein MAD1

References

(Earliest) J:53194 Jin DY, et al., Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5. Genomics. 1999 Feb 1;55(3):363-4
(Latest) J:176014 Fava LL, et al., Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint. EMBO J. 2011;30(16):3322-36
All references(39)

Other accession IDs

MGI:2140812, MGI:2141227