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Mad1l1 Gene Detail
Summary
  • Symbol
    Mad1l1
  • Name
    MAD1 mitotic arrest deficient 1-like 1
  • Synonyms
    Mad1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341857
    NCBI Gene: 17120
  • Gene Overview
    MyGene.info: MAD1L1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140008689-140321552 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 78.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341857
protein coding gene Chr5:140008689-140321586 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030295
protein coding gene Chr5:145052651-145381502 (-)
A/J MGP_AJ_G0030264
protein coding gene Chr5:138874194-139197524 (-)
AKR/J MGP_AKRJ_G0030196
protein coding gene Chr5:143218304-143544375 (-)
BALB/cJ MGP_BALBcJ_G0030281
protein coding gene Chr5:140124330-140442429 (-)
C3H/HeJ MGP_C3HHeJ_G0029992
protein coding gene Chr5:143996692-144320996 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030726
protein coding gene Chr5:150422708-150768713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027944
protein coding gene Chr5:132726256-133043595 (-)
CAST/EiJ MGP_CASTEiJ_G0029397
protein coding gene Chr5:143414491-143754792 (-)
CBA/J MGP_CBAJ_G0029962
protein coding gene Chr5:156621527-156956718 (-)
DBA/2J MGP_DBA2J_G0030112
protein coding gene Chr5:138692428-139009843 (-)
FVB/NJ MGP_FVBNJ_G0030067
protein coding gene Chr5:137830631-138152489 (-)
LP/J MGP_LPJ_G0030198
protein coding gene Chr5:145663228-145995290 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030098
protein coding gene Chr5:159217725-159550783 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030766
protein coding gene Chr5:143051406-143376406 (-)
PWK/PhJ MGP_PWKPhJ_G0029112
protein coding gene Chr5:137710045-138030891 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028948
protein coding gene Chr5:140740241-141071952 (-)
WSB/EiJ MGP_WSBEiJ_G0029471
protein coding gene Chr5:143833907-144160102 (-)



Homology
more
  • Human Ortholog
    MAD1L1, mitotic arrest deficient 1 like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAD1L1, mitotic arrest deficient 1 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAD1, PIG9, TP53I9, TXBP181
  • Links
    NCBI Gene ID: 8379
    neXtProt AC: NX_Q9Y6D9
    UniProt: Q9Y6D9

  • Chr Location
    7p22.3; chr7:1815792-2232971 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74500
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MAD1L1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MAD1L1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die in utero. Aging heterozygous null mice show increased tumor incidence while heterozygous MEFs are more prone to aneuploidy, induce fibrosarcomas in athymic nude mice, and show a weaker spindle assembly checkpoint-mediated arrest n response to nocodazole.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029554 Ensembl Gene Model | MGI Sequence Detail 312864 C57BL/6J ±  kb
transcript ENSMUST00000031534 Ensembl | MGI Sequence Detail 2640 Not Applicable  
polypeptide ENSMUSP00000031534 Ensembl | MGI Sequence Detail 717 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    cDNA 59

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140812, MGI:2141227
References
more
  • Summaries
    All 44
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:53194 Jin DY, et al., Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5. Genomics. 1999 Feb 1;55(3):363-4
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory