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Mad1l1
Gene Detail
 Symbol
Name
ID
Mad1l1
MAD1 mitotic arrest deficient 1-like 1
MGI:1341857
Synonyms Mad1
Feature Type protein coding gene
Genetic Map
Chromosome 5
78.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:140008689-140321552 bp, - strand
From VEGA annotation of GRCm38

  312864 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74500  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mad1l1

Human
homologs
Human Homolog MAD1L1, MAD1 mitotic arrest deficient-like 1 (yeast)
NCBI Gene ID 8379
neXtProt AC  NX_Q9Y6D9
Human Synonyms  MAD1, PIG9, TP53I9, TXBP181
Human Chr (Location)  7p22; chr7:1815792-2232948 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAD1L1
Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(59) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die in utero. Aging heterozygous null mice show increased tumor incidence while heterozygous MEFs are more prone to aneuploidy, induce fibrosarcomas in athymic nude mice, and show a weaker spindle assembly checkpoint-mediated arrest n response to nocodazole.
 
Interactions
Mad1l1 interacts with 127 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell cycle, cell division, ...
Component actin cytoskeleton, chromosome, ...
External Resources: FuncBase
Expression
cDNA source data(58)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(58)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030671 (Evidence)
Ensembl Gene ModelENSMUSG00000029554 (Evidence)
Entrez Gene17120 (Evidence)
UniGene27250
DFCITC1580541, TC1608448
DoTSDT.101350032, DT.101377704, DT.534780, DT.91326706, DT.97362009
NIA Mouse Gene IndexU128546
Consensus CDS ProjectCCDS19817.1
International Mouse Knockout Project StatusMad1l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030671 VEGA Gene Model | MGI Sequence Detail 312864 C57BL/6J ±  kb
transcript OTTMUST00000075923 VEGA | MGI Sequence Detail 2640 Not Applicable 
polypeptide OTTMUSP00000039890 VEGA | MGI Sequence Detail 717 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(203 from dbSNP Build 137)    SNPs within 2kb including multiple locations(205)
Protein-related
information
ResourceIDDescription
InterPro IPR008672 Spindle assembly checkpoint component Mad1
Protein Ontology PR:000010037 mitotic spindle assembly checkpoint protein MAD1
References (Earliest) J:53194 Jin DY, et al., Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5. Genomics. 1999 Feb 1;55(3):363-4
(Latest) J:176014 Fava LL, et al., Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint. EMBO J. 2011;30(16):3322-36
All references(41)
Other
accession IDs
MGI:2140812, MGI:2141227

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory