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Nod1 Gene Detail
Summary
  • Symbol
    Nod1
  • Name
    nucleotide-binding oligomerization domain containing 1
  • Synonyms
    Card4, F830007N14Rik, Nlrc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341839
    NCBI Gene: 107607
  • Gene Overview
    MyGene.info: NOD1
Location & Maps
more
  • Sequence Map
    Chr6:54923949-54972612 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48664 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.22 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NOD1, nucleotide binding oligomerization domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NOD1, nucleotide binding oligomerization domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CARD4, CLR7.1, NLRC1
  • Links
    NCBI Gene ID: 10392
    neXtProt AC: NX_Q9Y239

  • Chr Location
    7p14.3; chr7:30424527-30478797 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    86
  • Gene trapped
    83
  • Targeted
    3
  • Incidental Mutations
Homozygous mutant mice were viable, fertile, and appeared normal in a specific-pathogen free environment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057766 VEGA Gene Model | MGI Sequence Detail 48664 C57BL/6J ±  kb
transcript OTTMUST00000141867 VEGA | MGI Sequence Detail 4064 Not Applicable  
polypeptide OTTMUSP00000074069 VEGA | MGI Sequence Detail 953 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    227 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 3
Other
Accession IDs
less
MGI:2443700
References
more
  • Summaries
    All 93
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 55
  • Earliest
    J:55095 Inohara N, et al., Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 1999 May 21;274(21):14560-7
  • Latest
    J:234496 Vegna S, et al., NOD1 Participates in the Innate Immune Response Triggered by Hepatitis C Virus Polymerase. J Virol. 2016 Jul 1;90(13):6022-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory