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Nod1 Gene Detail
Summary
  • Symbol
    Nod1
  • Name
    nucleotide-binding oligomerization domain containing 1
  • Synonyms
    Card4, F830007N14Rik, Nlrc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341839
    NCBI Gene: 107607
Location & Maps
more
  • Sequence Map
    Chr6:54923949-54972612 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48664 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NOD1, nucleotide binding oligomerization domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NOD1, nucleotide binding oligomerization domain containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CARD4, CLR7.1, NLRC1
  • Links
    NCBI Gene ID: 10392
    neXtProt AC: NX_Q9Y239

  • Chr Location
    7p14.3; chr7:30424527-30478797 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    86
  • Gene trapped
    83
  • Targeted
    3
  • Incidental Mutations
Homozygous mutant mice were viable, fertile, and appeared normal in a specific-pathogen free environment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038058 Ensembl Gene Model | MGI Sequence Detail 48664 C57BL/6J ±  kb
transcript ENSMUST00000168172 Ensembl | MGI Sequence Detail 4064 Not Applicable  
polypeptide ENSMUSP00000130487 Ensembl | MGI Sequence Detail 953 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    228 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011305 nucleotide-binding oligomerization domain-containing protein 1
  • InterPro Domains
    IPR001315 CARD domain
    IPR011029 Death-like domain
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
    IPR007111 NACHT nucleoside triphosphatase
Molecular
Reagents
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  • All nucleic 49
    cDNA 49

    Microarray probesets 3
Other
Accession IDs
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MGI:2443700
References
more
  • Summaries
    All 88
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 53
  • Earliest
    J:55095 Inohara N, et al., Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 1999 May 21;274(21):14560-7
  • Latest
    J:219915 Powell JJ, et al., An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells. Nat Nanotechnol. 2015 May;10(4):361-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory