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Nod1
Gene Detail
Symbol

Name
ID
Nod1
nucleotide-binding oligomerization domain containing 1
MGI:1341839
Synonyms
Card4, F830007N14Rik, Nlrc1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:54923942-54972612 bp, - strand
From Ensembl annotation of GRCm38

  48671 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4440  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NOD1
Protein SuperFamily: caspase recruitment domain-containing protein, Nod1/Nod2 types
Gene Tree: Nod1

Human
homologs
NOD1, nucleotide-binding oligomerization domain containing 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10392
neXtProt AC: NX_Q9Y239

Human Synonyms: CARD4, CLR7.1, NLRC1

Human Chr (Location): 7p14.3; chr7:30424527-30478797 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(86) : Gene trapped(83) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice were viable, fertile, and appeared normal in a specific-pathogen free environment.
 
Interactions
Nod1 interacts with 141 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (33)    Tissues (16)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN nod1    NEW 
Molecular
reagents
All nucleic(49) cDNA(49)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000038058 (Evidence)
Entrez Gene 107607 (Evidence)
UniGene 28498
DFCI TC1577400
DoTS DT.101360081, DT.101386067, DT.101386068, DT.87068724
NIA Mouse Gene Index U027345
Consensus CDS Project CCDS20160.1
International Mouse Phenotyping Consortium Status Nod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038058 Ensembl Gene Model | MGI Sequence Detail 48671 C57BL/6J ±  kb
transcript ENSMUST00000060655 Ensembl | MGI Sequence Detail 4322 Not Applicable 
polypeptide ENSMUSP00000055747 Ensembl | MGI Sequence Detail 953 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(9) UniProt(2)
Polymorphisms
SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 CARD domain
InterPro IPR011029 Death-like domain
InterPro IPR007111 NACHT nucleoside triphosphatase
Protein Ontology PR:000011305 nucleotide-binding oligomerization domain-containing protein 1
References
(Earliest) J:55095 Inohara N, et al., Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 1999 May 21;274(21):14560-7
(Latest) J:219915 Powell JJ, et al., An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells. Nat Nanotechnol. 2015 May;10(4):361-9
All references(88)
Other
accession IDs
MGI:2443700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory