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Nod1
Gene Detail
 Symbol
Name
ID
Nod1
nucleotide-binding oligomerization domain containing 1
MGI:1341839
Synonyms Card4, F830007N14Rik, Nlrc1
Feature Type protein coding gene
Genetic Map
Chromosome 6
27.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:54923942-54972612 bp, - strand
From NCBI annotation of GRCm38

  48671 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4440  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: caspase recruitment domain-containing protein, Nod1/Nod2 types
Gene Tree: Nod1

Human
homologs
Human Homolog NOD1, nucleotide-binding oligomerization domain containing 1
NCBI Gene ID 10392
neXtProt AC  NX_Q9Y239
Human Synonyms  CARD4, CLR7.1, NLRC1
Human Chr (Location)  7p15-p14; chr7:30424527-30478784 (-)  GRCh38
Alleles
and
phenotypes
All alleles(86) : Targeted(3) Gene trapped(83)
 
Homozygous mutant mice were viable, fertile, and appeared normal in a specific-pathogen free environment.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component basolateral plasma membrane, cytoplasm, ...
Function ATP binding, CARD domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (33)    Tissues (16)    Images (15)
Theiler Stages: 23
Assay TypeResults
RNA in situ 33
cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) cDNA(49)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038058 (Evidence)
Entrez Gene107607 (Evidence)
UniGene28498
DFCITC1577400
DoTSDT.101360081, DT.101386067, DT.101386068, DT.87068724
NIA Mouse Gene IndexU027345
Consensus CDS ProjectCCDS20160.1
International Mouse Knockout Project StatusNod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 107607 NCBI Gene Model | MGI Sequence Detail 48671 C57BL/6J ±  kb
transcript NM_172729 RefSeq | MGI Sequence Detail 4327 C57BL/6 
polypeptide Q8BHB0 UniProt | EBI | MGI Sequence Detail 953 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(9) UniProt(2)
Polymorphisms SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR007111 NACHT nucleoside triphosphatase
Protein Ontology PR:000011305 nucleotide-binding oligomerization domain-containing protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:55095 Inohara N, et al., Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 1999 May 21;274(21):14560-7
(Latest) J:207016 Selvanantham T, et al., Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection. J Immunol. 2013 Dec 1;191(11):5646-54
All references(84)
Other
accession IDs
MGI:2443700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory