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Nod1 Gene Detail
Summary
  • Symbol
    Nod1
  • Name
    nucleotide-binding oligomerization domain containing 1
  • Synonyms
    Card4, F830007N14Rik, Nlrc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341839
    NCBI Gene: 107607
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:54900934-54949597 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341839
 protein coding gene Chr6:54900927-54949655 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030766
 protein coding gene Chr6:54311091-54365721 (-)
A/J MGP_AJ_G0030735
 protein coding gene Chr6:51790529-51842620 (-)
AKR/J MGP_AKRJ_G0030662
 protein coding gene Chr6:53548395-53601204 (-)
BALB/cJ MGP_BALBcJ_G0030747
 protein coding gene Chr6:52154976-52206126 (-)
C3H/HeJ MGP_C3HHeJ_G0030460
 protein coding gene Chr6:53570767-53624012 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031202
 protein coding gene Chr6:55519393-55571177 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028408
 protein coding gene Chr6:49400435-49449076 (-)
CAST/EiJ MGP_CASTEiJ_G0029863
 protein coding gene Chr6:53429897-53485908 (-)
CBA/J MGP_CBAJ_G0030434
 protein coding gene Chr6:57811081-57878036 (-)
DBA/2J MGP_DBA2J_G0030584
 protein coding gene Chr6:51690441-51744875 (-)
FVB/NJ MGP_FVBNJ_G0030536
 protein coding gene Chr6:51287366-51338318 (-)
LP/J MGP_LPJ_G0030669
 protein coding gene Chr6:54251592-54307490 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030570
 protein coding gene Chr6:60327577-60389526 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031232
 protein coding gene Chr6:53511943-53569887 (-)
PWK/PhJ MGP_PWKPhJ_G0029576
 protein coding gene Chr6:51352697-51404949 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029410
 protein coding gene Chr6:52898679-52947890 (-)
WSB/EiJ MGP_WSBEiJ_G0029940
 protein coding gene Chr6:53538547-53593256 (-)



Homology
more
  • Human Ortholog
    NOD1, nucleotide binding oligomerization domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOD1, nucleotide binding oligomerization domain containing 1
  • Synonyms
    CARD4, CLR7.1, hNod1, NLRC1
  • Links
    NCBI Gene ID: 10392
    neXtProt AC: NX_Q9Y239
    UniProt: Q9Y239

  • Chr Location
    7p14.3; chr7:30424527-30478784 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NOD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice were viable, fertile, and appeared normal in a specific-pathogen free environment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    19
  • cDNA Data
    49
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038058 Ensembl Gene Model | MGI Sequence Detail 48664 C57BL/6J ±  kb
transcript ENSMUST00000168172 Ensembl | MGI Sequence Detail 4064 Not Applicable  
polypeptide ENSMUSP00000130487 Ensembl | MGI Sequence Detail 953 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011305 nucleotide-binding oligomerization domain-containing protein 1
    (term hierarchy)
  • InterPro Domains
    IPR001315 CARD domain
    IPR011029 Death-like domain superfamily
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
    IPR007111 NACHT nucleoside triphosphatase
    IPR041075 NOD2, winged helix domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 50
    cDNA 49
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2443700
References
more
  • Summaries
    All 158
    Developmental Gene Expression 3
    Gene Ontology 17
    Phenotypes 84
  • Earliest
    J:55095 Inohara N, et al., Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 1999 May 21;274(21):14560-7
  • Latest
    J:335599 Bharadwaj R, et al., Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity. Immunity. 2023 May 9;56(5):998-1012.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory