Kcnh1
Gene Detail

Symbol Name ID

Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 MGI:1341721

Synonyms

ether a go-go, Kv10.1, M-eag

Feature Type

protein coding gene

Genetic Map

Chromosome 1

97.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:192190784-192510159 bp, + strand From VEGA annotation of GRCm38   319376 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh1

Human homologs

Human Homolog		KCNH1, potassium voltage-gated channel, subfamily H (eag-related), member 1
NCBI Gene ID		3756
neXtProt AC		NX_O95259
Human Synonyms		EAG, EAG1, h-eag, Kv10.1
Human Chr (Location)		1q32.2; chr1:210851657-211307457 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(1) Gene trapped(2)
 

Homozygous mutant mice exhibit a decreased depressive-like response during tail suspension testing.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	ion transport, phosphorelay signal transduction system, ...
Component	integral to membrane, membrane, ...
Function	calmodulin binding, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (49)    Tissues (46)    Images (1)
Theiler Stages: 23, 25, 28

Assay Type	Results
RT-PCR	49

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(24) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024518 (Evidence)
Ensembl Gene Model	ENSMUSG00000058248 (Evidence)
Entrez Gene	16510 (Evidence)
UniGene	4489
DFCI	TC1580771, TC1595236, TC1604220, TC1674314
DoTS	DT.40157922, DT.55205745
NIA Mouse Gene Index	U042248
PDB	4F8A
Consensus CDS Project	CCDS15627.1, CCDS35826.1
International Mouse Knockout Project Status	Kcnh1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024518	VEGA Gene Model | MGI Sequence Detail	319376	C57BL/6J
transcript	OTTMUST00000060175	VEGA | MGI Sequence Detail	7232	Not Applicable
polypeptide	OTTMUSP00000029345	VEGA | MGI Sequence Detail	989	Not Applicable

All sequences(38) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(1841 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR001610	PAC motif
InterPro	IPR000700	PAS-associated, C-terminal
InterPro	IPR000014	PAS domain
InterPro	IPR003949	Potassium channel, voltage-dependent, EAG
InterPro	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000000790	voltage-gated potassium channel KCNH1

References

(Earliest) J:18517 Warmke JW, et al., A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3438-42
(Latest) J:188709 Ninkovic M, et al., Physical and functional interaction of K(V)10.1 with Rabaptin-5 impacts ion channel trafficking. FEBS Lett. 2012 Sep 21;586(19):3077-84
All references(33)