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Kcnh1
Gene Detail
 Symbol
Name
ID
Kcnh1
potassium voltage-gated channel, subfamily H (eag-related), member 1
MGI:1341721
Synonyms Eag1, ether a go-go, Kv10.1
Feature Type protein coding gene
Genetic Map
Chromosome 1
97.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:192190784-192510159 bp, + strand
From VEGA annotation of GRCm38

  319376 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh1

Human
homologs
Human Homolog KCNH1, potassium voltage-gated channel, subfamily H (eag-related), member 1
NCBI Gene ID 3756
neXtProt AC  NX_O95259
Human Synonyms  EAG, EAG1, h-eag, Kv10.1
Human Chr (Location)  1q32.2; chr1:210678315-211134115 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit a decreased depressive-like response during tail suspension testing. Mice homozygous for a different knock-out allele exhibit longer latency to move in haloperidol-treated mice and mild hyperactivity.
 
Interactions
Kcnh1 interacts with 349 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process ion transport, phosphorelay signal transduction system, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function calmodulin binding, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (49)    Tissues (47)    Images (1)
Theiler Stages: 23, 25, 27, 28
Assay TypeResults
RT-PCR 49
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(26) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024518 (Evidence)
Ensembl Gene ModelENSMUSG00000058248 (Evidence)
Entrez Gene16510 (Evidence)
UniGene4489
DFCITC1580771, TC1595236, TC1604220, TC1674314
DoTSDT.110919476, DT.40157922, DT.55205745
NIA Mouse Gene IndexU042248
PDB4F8A, 4HOI, 4LLO
Consensus CDS ProjectCCDS15627.1, CCDS35826.1
International Mouse Knockout Project StatusKcnh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024518 VEGA Gene Model | MGI Sequence Detail 319376 C57BL/6J ±  kb
transcript OTTMUST00000060175 VEGA | MGI Sequence Detail 7232 Not Applicable 
polypeptide OTTMUSP00000029345 VEGA | MGI Sequence Detail 989 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(9) UniProt(5)
Polymorphisms SNPs within 2kb(2938 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2946)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR001610 PAC motif
InterPro IPR000700 PAS-associated, C-terminal
InterPro IPR000014 PAS domain
InterPro IPR003949 Potassium channel, voltage-dependent, EAG
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000790 voltage-gated potassium channel KCNH1
References (Earliest) J:18517 Warmke JW, et al., A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3438-42
(Latest) J:198153 Ufartes R, et al., Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice. Hum Mol Genet. 2013 Jun 1;22(11):2247-62
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory