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Gldc Gene Detail
Summary
  • Symbol
    Gldc
  • Name
    glycine decarboxylase
  • Synonyms
    D030049L12Rik, D19Wsu57e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341155
    NCBI Gene: 104174
Location & Maps
more
  • Sequence Map
    Chr19:30098449-30175418 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76970 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GLDC, glycine decarboxylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLDC, glycine decarboxylase
    Orthology source: HomoloGene
  • Synonyms
    GCE, GCSP, HYGN1
  • Links
    NCBI Gene ID: 2731
    neXtProt AC: NX_P23378

  • Chr Location
    9p22; chr9:6532464-6645692 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GLDC associations

Human Disease Mouse Models
       Glycine Encephalopathy; GCE   OMIM: 605899
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024827 Ensembl Gene Model | MGI Sequence Detail 76970 C57BL/6J ±  kb
transcript ENSMUST00000025778 Ensembl | MGI Sequence Detail 3754 Not Applicable  
polypeptide ENSMUSP00000025778 Ensembl | MGI Sequence Detail 1025 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    750 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008022 glycine dehydrogenase [decarboxylating], mitochondrial
  • EC
  • InterPro Domains
    IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
    IPR020581 Glycine cleavage system P protein
    IPR020580 Glycine cleavage system P-protein, N-terminal
    IPR003437 Glycine dehydrogenase (decarboxylating)
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
Molecular
Reagents
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  • All nucleic 100
    Genomic 2
    cDNA 95
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-33938, MGI:106246, MGI:2441935
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:221782 Pai YJ, et al., Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Nat Commun. 2015;6:6388

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory