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Gldc
Gene Detail
Symbol

Name
ID
Gldc
glycine decarboxylase
MGI:1341155
Synonyms
D030049L12Rik, D19Wsu57e
Feature Type
protein coding gene
Genetic Map
Chromosome 19
24.87 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:30098449-30175418 bp, - strand
From Ensembl annotation of GRCm38

  76970 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:141  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glycine dehydrogenase
Gene Tree: Gldc

Human
homologs
Human Homolog GLDC, glycine dehydrogenase (decarboxylating)
NCBI Gene ID 2731
neXtProt AC  NX_P23378
Human Synonyms  GCE, GCSP, HYGN1
Human Chr (Location)  9p22; chr9:6532464-6645692 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GLDC
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gldc interacts with 126 markers (Mir7-1, Mir30a, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular amino acid metabolic process, glycine catabolic process, ...
Component glycine cleavage complex, mitochondrion
Function catalytic activity, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (142)    Tissues (133)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 136
RT-PCR 6
cDNA source data(94)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) Genomic(2) cDNA(95) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024827 (Evidence)
Entrez Gene104174 (Evidence)
UniGene274852
DFCITC1613547, TC1574974
DoTSDT.531534, DT.40175623, DT.94169425, DT.97335745
NIA Mouse Gene IndexU038964
EC1.4.4.2
Consensus CDS ProjectCCDS37956.1
International Mouse Knockout Project StatusGldc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024827 Ensembl Gene Model | MGI Sequence Detail 76970 C57BL/6J ±  kb
transcript ENSMUST00000025778 Ensembl | MGI Sequence Detail 3754 Not Applicable 
polypeptide ENSMUSP00000025778 Ensembl | MGI Sequence Detail 1025 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(750 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
InterPro IPR020581 Glycine cleavage system P protein
InterPro IPR003437 Glycine cleavage system P protein, homodimeric
InterPro IPR020580 Glycine cleavage system P-protein, N-terminal
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
Protein Ontology PR:000008022 glycine dehydrogenase [decarboxylating], mitochondrial
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(41)
Other
accession IDs
MGD-MRK-33938, MGI:106246, MGI:2441935

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory