About   Help   FAQ
Gldc Gene Detail
Summary
  • Symbol
    Gldc
  • Name
    glycine decarboxylase
  • Synonyms
    b2b2679Clo, D030049L12Rik, D19Wsu57e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341155
    NCBI Gene: 104174
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:30098449-30175418 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76970 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 24.87 cM, cytoband C
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GLDC, glycine decarboxylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLDC, glycine decarboxylase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCE, GCSP, HYGN1
  • Links
    NCBI Gene ID: 2731
    neXtProt AC: NX_P23378
    UniProt: P23378

  • Chr Location
    9p24.1; chr9:6532464-6645692 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gldc mouse models; 1 with human GLDC associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    6 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hypomorphic mutants show a developmental delay, hyperglycinemia, altered folate profiles, neural tube defects and postnatal lethality, while survivors show hydrocephaly and premature death. Homozygotes for an ENU allele show omphalocele and severe cardiovascular, craniofacial, renal and eye defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024827 Ensembl Gene Model | MGI Sequence Detail 76970 C57BL/6J ±  kb
    transcript ENSMUST00000025778 Ensembl | MGI Sequence Detail 3754 Not Applicable  
    polypeptide ENSMUSP00000025778 Ensembl | MGI Sequence Detail 1025 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      750 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008022 glycine dehydrogenase [decarboxylating], mitochondrial
    • EC
    • InterPro Domains
      IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
      IPR020581 Glycine cleavage system P protein
      IPR003437 Glycine dehydrogenase (decarboxylating)
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015422 Pyridoxal phosphate-dependent transferase domain 1
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
    Molecular
    Reagents
    less
    • All nucleic 100
      Genomic 2
      cDNA 95
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33938, MGI:106246, MGI:2441935, MGI:5560791
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:253359 Autuori MC, et al., Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice. Prenat Diagn. 2017 Mar;37(3):273-281

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory