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Tnks
Gene Detail
 Symbol
Name
ID
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
MGI:1341087
Synonyms 4930554K12Rik, D130072O21Rik, mTNKS1, TANK1, tankyrase 1
Feature Type protein coding gene
Genetic Map
Chromosome 8
21.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:34829179-34965690 bp, - strand
From NCBI annotation of GRCm38

  136512 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18405  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tnks

Human
homologs
Human Homolog TNKS, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
NCBI Gene ID 8658
neXtProt AC  NX_O95271
Human Synonyms  ARTD5, PARP-5a, PARP5A, PARPL, pART5, TIN1, TINF1, TNKS1
Human Chr (Location)  8p23.1; chr8:9555251-9782346 (+)  GRCh38
Alleles
and
phenotypes
All alleles(31) : Gene trapped(27) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele fail to exhibit any abonormalities. Male mice homozygous for a gene trapped allele exhibit decreased fat pad weight, increased metabolism, hyperinsulinemia, and hypoglycemia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell cycle, cell division, ...
Component chromosome, chromosome, centromeric region, ...
Function metal ion binding, NAD+ ADP-ribosyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (89)    Tissues (11)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 89
cDNA source data(181)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(181) cDNA(181)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000031529 (Evidence)
Entrez Gene21951 (Evidence)
UniGene88364
DFCITC1577213, TC1582661, TC1595928, TC1604272, TC1705595, TC1773878
DoTSDT.101153262, DT.101158116, DT.527100, DT.91347371, DT.94327980
NIA Mouse Gene IndexU029722
EC2.4.2.30
PDB3UTM, 4N4T
Consensus CDS ProjectCCDS22242.1
International Mouse Knockout Project StatusTnks
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21951 NCBI Gene Model | MGI Sequence Detail 136512 C57BL/6J ±  kb
transcript NM_175091 RefSeq | MGI Sequence Detail 6444 C57BL/6 
polypeptide Q6PFX9 UniProt | EBI | MGI Sequence Detail 1320 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(1145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000016497 tankyrase-1
Graphical View of Protein Domain Structure
References (Earliest) J:51381 Zhu L, et al., Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics. 1999;57:320-321
(Latest) J:201692 Wentzel C, et al., mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron. 2013 Jun 19;78(6):1012-23
All references(45)
Other
accession IDs
MGI:1922501, MGI:2142612, MGI:2142876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory