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Tnks Gene Detail
Summary
  • Symbol
    Tnks
  • Name
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
  • Synonyms
    4930554K12Rik, D130072O21Rik, mTNKS1, TANK1, tankyrase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341087
    NCBI Gene: 21951
  • Gene Overview
    MyGene.info: TNKS
Location & Maps
more
  • Sequence Map
    Chr8:34826460-34965690 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      139231 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 21.16 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TNKS, tankyrase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNKS, tankyrase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARTD5, PARP-5a, PARP5A, PARPL, pART5, TIN1, TINF1, TNKS1
  • Links
    NCBI Gene ID: 8658
    neXtProt AC: NX_O95271

  • Chr Location
    8p23.1; chr8:9555214-9782346 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 18405
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TNKS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Gene trapped
    27
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a null allele fail to exhibit any abonormalities. Male mice homozygous for a gene trapped allele exhibit decreased fat pad weight, increased metabolism, hyperinsulinemia, and hypoglycemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061012 VEGA Gene Model | MGI Sequence Detail 139231 C57BL/6J ±  kb
transcript OTTMUST00000149093 VEGA | MGI Sequence Detail 9163 Not Applicable  
polypeptide OTTMUSP00000077412 VEGA | MGI Sequence Detail 1320 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1135 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 181
    cDNA 181

    Microarray probesets 7
Other
Accession IDs
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MGI:1922501, MGI:2142612, MGI:2142876
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:51381 Zhu L, et al., Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics. 1999;57:320-321
  • Latest
    J:201692 Wentzel C, et al., mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron. 2013 Jun 19;78(6):1012-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory