About   Help   FAQ
Chil1 Gene Detail
Summary
  • Symbol
    Chil1
  • Name
    chitinase-like 1
  • Synonyms
    Brp39, Chi3l1, Gp39
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340899
    NCBI Gene: 12654
  • Gene Overview
    MyGene.info: CHI3L1
Location & Maps
more
  • Sequence Map
    Chr1:134182176-134190181 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8006 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.15 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CHI3L1, chitinase 3 like 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CHI3L1, chitinase 3 like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ASRT7, CGP-39, GP39, GP-39, hCGP-39, HC-gp39, HCGP-3P, YKL40, YKL-40, YYL-40
  • Links
    NCBI Gene ID: 1116
    neXtProt AC: NX_P36222

  • Chr Location
    1q32.1; chr1:203178931-203186960 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human CHI3L1 associations

Human Disease Mouse Models
       Asthma-Related Traits, Susceptibility to, 7; ASRT7   OMIM: 611960
Schizophrenia; SCZD   OMIM: 181500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    2
  • Genomic Mutations
    3 involving Chil1
  • Incidental Mutations
Homozygous null mice show impaired OVA-induced Th2 responses with reduced splenocyte proliferation, cytokine production and IgE levels, impaired dendritic cell recruitment, higher CD4 T cell, macrophage and eosinophil apoptosis, and reduced CD4 T cell and alternatively activated macrophage numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030091 VEGA Gene Model | MGI Sequence Detail 8006 C57BL/6J ±  kb
transcript OTTMUST00000074544 VEGA | MGI Sequence Detail 1839 Not Applicable  
polypeptide OTTMUSP00000038876 VEGA | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    106 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005423 chitinase-3-like protein 1
  • InterPro Domains
    IPR028538 Chitinase-3-like protein 1
    IPR011583 Chitinase II
    IPR029070 Chitinase insertion domain
    IPR013781 Glycoside hydrolase, catalytic domain
    IPR001223 Glycoside hydrolase family 18, catalytic domain
    IPR017853 Glycoside hydrolase superfamily
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36073, MGI:107503, MGI:2138570
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:21836 Morrison BW, et al., neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene. 1994 Dec;9(12):3417-26
  • Latest
    J:229930 Nechiporuk T, et al., The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory