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Chil1
Gene Detail
Symbol

Name
ID
Chil1
chitinase-like 1
MGI:1340899
Synonyms
Brp39, Chi3l1, Gp39
Feature Type
protein coding gene
Genetic Map
Chromosome 1
58.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:134182176-134190181 bp, + strand
From VEGA annotation of GRCm38

  8006 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55569  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CHI3L1
Protein SuperFamily: chitinase-like protein
Gene Tree: Chil1

Human
homologs
CHI3L1, chitinase 3-like 1 (cartilage glycoprotein-39)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1116
neXtProt AC: NX_P36222

Human Synonyms: ASRT7, CGP-39, GP39, GP-39, hCGP-39, HC-gp39, HCGP-3P, YKL40, YKL-40, YYL-40

Human Chr (Location): 1q32.1; chr1:203178931-203186960 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CHI3L1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(3) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice show impaired OVA-induced Th2 responses with reduced splenocyte proliferation, cytokine production and IgE levels, impaired dendritic cell recruitment, higher CD4 T cell, macrophage and eosinophil apoptosis, and reduced CD4 T cell and alternatively activated macrophage numbers.
 
Interactions
Chil1 interacts with 114 markers (Mir24-1, Mir24-2, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process activation of NF-kappaB-inducing kinase activity, apoptotic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function chitinase activity, chitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (94)    Tissues (94)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(100)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) cDNA(100)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030091 (Evidence)
Ensembl Gene Model ENSMUSG00000064246 (Evidence)
Entrez Gene 12654 (Evidence)
UniGene 38274
DFCI TC1577153
DoTS DT.101372642, DT.110916389, DT.489200
NIA Mouse Gene Index U000823
Consensus CDS Project CCDS48368.1
International Mouse Phenotyping Consortium Status Chil1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030091 VEGA Gene Model | MGI Sequence Detail 8006 C57BL/6J ±  kb
transcript OTTMUST00000074544 VEGA | MGI Sequence Detail 1839 Not Applicable 
polypeptide OTTMUSP00000038876 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028538 Chitinase-3-like protein 1
InterPro IPR011583 Chitinase II
InterPro IPR029070 Chitinase insertion domain
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001223 Glycoside hydrolase family 18, catalytic domain
InterPro IPR017853 Glycoside hydrolase superfamily
Protein Ontology PR:000005423 chitinase-3-like protein 1
References
(Earliest) J:21836 Morrison BW, et al., neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene. 1994 Dec;9(12):3417-26
(Latest) J:217738 Ma B, et al., Role of Chitinase 3-like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis. Cancer Res. 2015 Feb 1;75(3):487-96
All references(43)
Other
accession IDs
MGD-MRK-36073, MGI:107503, MGI:2138570

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory