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Chil1 Gene Detail
Summary
  • Symbol
    Chil1
  • Name
    chitinase-like 1
  • Synonyms
    Brp39, Chi3l1, Gp39
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340899
    NCBI Gene: 12654
  • Gene Overview
    MyGene.info: CHI3L1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:134182176-134190181 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8006 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.15 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CHI3L1, chitinase 3 like 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CHI3L1, chitinase 3 like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ASRT7, CGP-39, GP39, GP-39, hCGP-39, HC-gp39, HCGP-3P, YK-40, YKL40, YKL-40, YYL-40
  • Links
    NCBI Gene ID: 1116
    neXtProt AC: NX_P36222
    UniProt: P36222

  • Chr Location
    1q32.1; chr1:203178931-203186794 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CHI3L1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show impaired OVA-induced Th2 responses with reduced splenocyte proliferation, cytokine production and IgE levels, impaired dendritic cell recruitment, higher CD4 T cell, macrophage and eosinophil apoptosis, and reduced CD4 T cell and alternatively activated macrophage numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030091 VEGA Gene Model | MGI Sequence Detail 8006 C57BL/6J ±  kb
    transcript OTTMUST00000074544 VEGA | MGI Sequence Detail 1839 Not Applicable  
    polypeptide OTTMUSP00000038876 VEGA | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      106 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 101

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-36073, MGI:107503, MGI:2138570
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:258853 Zhou Y, et al., Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease. J Immunol. 2018 Mar 15;200(6):2140-2153

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory