Chi3l1
Gene Detail

Symbol Name ID

Chi3l1 chitinase 3-like 1 MGI:1340899

Synonyms

Brp39, Gp39

Feature Type

protein coding gene

Genetic Map

Chromosome 1

58.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:134182176-134190181 bp, + strand From VEGA annotation of GRCm38   8006 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55569  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chitinase-like protein
Gene Tree: Chi3l1

Human homologs

Human Homolog		CHI3L1, chitinase 3-like 1 (cartilage glycoprotein-39)
NCBI Gene ID		1116
neXtProt AC		NX_P36222
Human Synonyms		ASRT7, CGP-39, GP39, GP-39, hCGP-39, HC-gp39, HCGP-3P, YKL40, YKL-40, YYL-40
Human Chr (Location)		1q32.1; chr1:203148059-203155922 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CHI3L1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice show impaired OVA-induced Th2 responses with reduced splenocyte proliferation, cytokine production and IgE levels, impaired dendritic cell recruitment, higher CD4 T cell, macrophage and eosinophil apoptosis, and reduced CD4 T cell and alternatively activated macrophage numbers.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	activation of NF-kappaB-inducing kinase activity, carbohydrate metabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	catalytic activity, chitinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (5)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(100) cDNA(100)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030091 (Evidence)
Ensembl Gene Model	ENSMUSG00000064246 (Evidence)
Entrez Gene	12654 (Evidence)
UniGene	38274
DFCI	TC1577153
DoTS	DT.101372642, DT.110916389, DT.489200
NIA Mouse Gene Index	U000823
Consensus CDS Project	CCDS48368.1
International Mouse Knockout Project Status	Chi3l1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030091	VEGA Gene Model | MGI Sequence Detail	8006	C57BL/6J
transcript	OTTMUST00000074544	VEGA | MGI Sequence Detail	1839	Not Applicable
polypeptide	OTTMUSP00000038876	VEGA | MGI Sequence Detail	381	Not Applicable

All sequences(51) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011583	Chitinase II
InterPro	IPR013781	Glycoside hydrolase, catalytic domain
InterPro	IPR001223	Glycoside hydrolase, family 18, catalytic domain
InterPro	IPR017853	Glycoside hydrolase, superfamily
Protein Ontology	PR:000005423	chitinase-3-like protein 1

References

(Earliest) J:21836 Morrison BW, et al., neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene. 1994 Dec;9(12):3417-26
(Latest) J:180536 Chen CC, et al., Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells. Clin Immunol. 2011 Sep;140(3):268-75
All references(38)

Other accession IDs

MGD-MRK-36073, MGI:107503, MGI:2138570