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Chil1
Gene Detail
 Symbol
Name
ID
Chil1
chitinase-like 1
MGI:1340899
Synonyms Brp39, Chi3l1, Gp39
Feature Type protein coding gene
Genetic Map
Chromosome 1
58.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:134182176-134190181 bp, + strand
From VEGA annotation of GRCm38

  8006 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55569  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chitinase-like protein
Gene Tree: Chil1

Human
homologs
Human Homolog CHI3L1, chitinase 3-like 1 (cartilage glycoprotein-39)
NCBI Gene ID 1116
neXtProt AC  NX_P36222
Human Synonyms  ASRT7, CGP-39, GP39, GP-39, hCGP-39, HC-gp39, HCGP-3P, YKL40, YKL-40, YYL-40
Human Chr (Location)  1q32.1; chr1:203178931-203186794 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CHI3L1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show impaired OVA-induced Th2 responses with reduced splenocyte proliferation, cytokine production and IgE levels, impaired dendritic cell recruitment, higher CD4 T cell, macrophage and eosinophil apoptosis, and reduced CD4 T cell and alternatively activated macrophage numbers.
 
Interactions
Chil1 interacts with 114 markers (Mir24-1, Mir24-2, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process activation of NF-kappaB-inducing kinase activity, apoptotic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function chitinase activity, chitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (94)    Tissues (94)    Images (5)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(100)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) cDNA(100)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030091 (Evidence)
Ensembl Gene ModelENSMUSG00000064246 (Evidence)
Entrez Gene12654 (Evidence)
UniGene38274
DFCITC1577153
DoTSDT.101372642, DT.110916389, DT.489200
NIA Mouse Gene IndexU000823
Consensus CDS ProjectCCDS48368.1
International Mouse Knockout Project StatusChil1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030091 VEGA Gene Model | MGI Sequence Detail 8006 C57BL/6J ±  kb
transcript OTTMUST00000074544 VEGA | MGI Sequence Detail 1839 Not Applicable 
polypeptide OTTMUSP00000038876 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011583 Chitinase II
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001223 Glycoside hydrolase, family 18, catalytic domain
InterPro IPR017853 Glycoside hydrolase, superfamily
Protein Ontology PR:000005423 chitinase-3-like protein 1
References (Earliest) J:21836 Morrison BW, et al., neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene. 1994 Dec;9(12):3417-26
(Latest) J:202854 He CH, et al., Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor alpha2. Cell Rep. 2013 Aug 29;4(4):830-41
All references(41)
Other
accession IDs
MGD-MRK-36073, MGI:107503, MGI:2138570

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory