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Pak1 Gene Detail
Summary
  • Symbol
    Pak1
  • Name
    p21 (RAC1) activated kinase 1
  • Synonyms
    PAK-1, Paka
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339975
    NCBI Gene: 18479
  • Gene Overview
    MyGene.info: PAK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:97788541-97912381 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123841 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.57 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PAK1, p21 (RAC1) activated kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PAK1, p21 (RAC1) activated kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAKalpha
  • Links
    NCBI Gene ID: 5058
    neXtProt AC: NX_Q13153
    UniProt: Q13153

  • Chr Location
    11q13.5-q14.1; chr11:77322015-77474063 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display defects in allergen-induced mast cell migration and degranulation. Mice homozygous for a different knock-out allele exhibit reduced long term potentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021135 VEGA Gene Model | MGI Sequence Detail 123841 C57BL/6J ±  kb
    transcript OTTMUST00000144026 VEGA | MGI Sequence Detail 2794 Not Applicable  
    polypeptide OTTMUSP00000075088 VEGA | MGI Sequence Detail 544 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      749 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 54
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1203486, MGI:2142185
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 29
      Gene Ontology 26
      Phenotypes 47
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:258027 Gstrein T, et al., Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat Neurosci. 2018 Feb;21(2):207-217

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory