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Pak1
Gene Detail
Symbol

Name
ID
Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
MGI:1339975
Synonyms
PAK-1, Paka
Feature Type
protein coding gene
Genetic Map
Chromosome 7
53.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:97842935-97912381 bp, + strand
From VEGA annotation of GRCm38

  69447 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1936  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PAK1
Gene Tree: Pak1

Human
homologs
PAK1, p21 protein (Cdc42/Rac)-activated kinase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5058
neXtProt AC: NX_Q13153

Human Synonyms: PAKalpha

Human Chr (Location): 11q13-q14; chr11:77321551-77474063 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(59) : Gene trapped(54) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele display defects in allergen-induced mast cell migration and degranulation.
 
Interactions
Pak1 interacts with 220 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (89 annotations)
Process actin cytoskeleton organization, actin cytoskeleton reorganization, ...
Component axon, cell, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (402)    Tissues (189)    Images (74)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 45
RNA in situ 268
Northern blot 18
Western blot 67
RT-PCR 4
cDNA source data(53)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pak1 ; ZFIN pak1    NEW 
Molecular
reagents
All nucleic(57) Genomic(1) cDNA(53) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000021135 (Evidence)
Ensembl Gene Model ENSMUSG00000030774 (Evidence)
Entrez Gene 18479 (Evidence)
UniGene 260227
DFCI TC1597406, TC1585025, TC1601087, TC1641535, TC1622084
DoTS DT.97356346, DT.489154, DT.101407514, DT.101254544
NIA Mouse Gene Index U008421
EC 2.7.11.1
Consensus CDS Project CCDS21464.1
International Mouse Phenotyping Consortium Status Pak1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021135 VEGA Gene Model | MGI Sequence Detail 69447 C57BL/6J ±  kb
transcript OTTMUST00000050033 VEGA | MGI Sequence Detail 3065 Not Applicable 
polypeptide OTTMUSP00000023295 VEGA | MGI Sequence Detail 544 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(432 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000095 PAK-box/P21-Rho-binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012239 serine/threonine-protein kinase PAK 1
References
(Earliest) J:40334 Osada S, et al., YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Oncogene. 1997 May 1;14(17):2047-57
(Latest) J:219424 Molosh AI, et al., Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. Nat Neurosci. 2014 Nov;17(11):1583-90
All references(96)
Other
accession IDs
MGI:1203486, MGI:2142185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory