About   Help   FAQ
Pak1 Gene Detail
Summary
  • Symbol
    Pak1
  • Name
    p21 protein (Cdc42/Rac)-activated kinase 1
  • Synonyms
    PAK-1, Paka
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339975
    NCBI Gene: 18479
  • Gene Overview
    MyGene.info: PAK1
Location & Maps
more
  • Sequence Map
    Chr7:97788541-97912381 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123841 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.57 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PAK1, p21 (RAC1) activated kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PAK1, p21 (RAC1) activated kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAKalpha
  • Links
    NCBI Gene ID: 5058
    neXtProt AC: NX_Q13153

  • Chr Location
    11q13.5-q14.1; chr11:77321551-77474063 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    63
  • Chemically induced (other)
    1
  • Gene trapped
    54
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Pak1
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele display defects in allergen-induced mast cell migration and degranulation. Mice homozygous for a different knock-out allele exhibit reduced long term potentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021135 VEGA Gene Model | MGI Sequence Detail 123841 C57BL/6J ±  kb
transcript OTTMUST00000050033 VEGA | MGI Sequence Detail 3065 Not Applicable  
polypeptide OTTMUSP00000023295 VEGA | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    749 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 57
    Genomic 1
    cDNA 53
    Primer pair 2
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1203486, MGI:2142185
References
more
  • Summaries
    All 107
    Developmental Gene Expression 26
    Gene Ontology 20
    Phenotypes 38
  • Earliest
    J:40334 Osada S, et al., YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Oncogene. 1997 May 1;14(17):2047-57
  • Latest
    J:225713 Pan X, et al., PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation. Mol Brain. 2015;8:36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory