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Pak1
Gene Detail
 Symbol
Name
ID
Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
MGI:1339975
Synonyms PAK-1, Paka
Feature Type protein coding gene
Genetic Map
Chromosome 7
53.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:97842935-97912381 bp, + strand
From VEGA annotation of GRCm38

  69447 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1936  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pak1

Human
homologs
Human Homolog PAK1, p21 protein (Cdc42/Rac)-activated kinase 1
NCBI Gene ID 5058
neXtProt AC  NX_Q13153
Human Synonyms  PAKalpha
Human Chr (Location)  11q13-q14; chr11:77322015-77474063 (-)  GRCh38
Alleles
and
phenotypes
All alleles(58) : Gene trapped(54) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele display defects in allergen-induced mast cell migration and degranulation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process actin cytoskeleton reorganization, apoptotic process, ...
Component axon, cell-cell junction, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (402)    Tissues (187)    Images (74)
Theiler Stages: 4, 5, 11, 13, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 45
RNA in situ 268
Northern blot 18
Western blot 67
RT-PCR 4
cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(57) Genomic(1) cDNA(53) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000021135 (Evidence)
Ensembl Gene ModelENSMUSG00000030774 (Evidence)
Entrez Gene18479 (Evidence)
UniGene260227
DFCITC1585025, TC1597406, TC1601087, TC1622084, TC1641535
DoTSDT.101254544, DT.101407514, DT.489154, DT.97356346
NIA Mouse Gene IndexU008421
EC2.7.11.1
Consensus CDS ProjectCCDS21464.1
International Mouse Knockout Project StatusPak1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021135 VEGA Gene Model | MGI Sequence Detail 69447 C57BL/6J ±  kb
transcript OTTMUST00000050033 VEGA | MGI Sequence Detail 3065 Not Applicable 
polypeptide OTTMUSP00000023295 VEGA | MGI Sequence Detail 544 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(432 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000095 PAK-box/P21-Rho-binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012239 serine/threonine-protein kinase PAK 1
References (Earliest) J:40334 Osada S, et al., YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Oncogene. 1997 May 1;14(17):2047-57
(Latest) J:203580 Gustafsson K, et al., The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp Cell Res. 2013 Jul 15;319(12):1852-64
All references(87)
Other
accession IDs
MGI:1203486, MGI:2142185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory