About   Help   FAQ
Cth
Gene Detail
 Symbol
Name
ID
Cth
cystathionase (cystathionine gamma-lyase)
MGI:1339968
Synonyms 0610010I13Rik, CSE, MGC:28655
Feature Type protein coding gene
Genetic Map
Chromosome 3
81.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:157894248-157925077 bp, - strand
From VEGA annotation of GRCm38

  30830 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cystathionine gamma-synthase
Gene Tree: Cth

Human
homologs
Human Homolog CTH, cystathionase (cystathionine gamma-lyase)
NCBI Gene ID 1491
neXtProt AC  NX_P32929
Human Chr (Location)  1p31.1; chr1:70411218-70439851 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CTH
Alleles
and
phenotypes
All alleles(16) : Targeted(4) Gene trapped(12)
 
Mice homozygous for a null allele exhibit hypertension associated with impaired endothelium-dependent vasorelaxation. Mice homozygous for another knock-out allele exhibit normal blood pressure but sensitivty to a low cysteine diet.
 
Human Diseases Modeled Using Mouse Cth (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cellular amino acid biosynthetic process, cysteine biosynthetic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function calmodulin binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (224)    Tissues (123)    Images (33)
Theiler Stages: 20, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 13
RNA in situ 167
Northern blot 12
Western blot 32
cDNA source data(76)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029713 (Evidence)
Ensembl Gene ModelENSMUSG00000028179 (Evidence)
Entrez Gene107869 (Evidence)
UniGene28301
DFCITC1578221
DoTSDT.490723
NIA Mouse Gene IndexU024795
EC4.4.1.1
Consensus CDS ProjectCCDS51101.1
International Mouse Knockout Project StatusCth
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029713 VEGA Gene Model | MGI Sequence Detail 30830 C57BL/6J ±  kb
transcript OTTMUST00000073720 VEGA | MGI Sequence Detail 1815 Not Applicable 
polypeptide OTTMUSP00000038207 VEGA | MGI Sequence Detail 398 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000006004 cystathionine gamma-lyase
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206814 King AL, et al., Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3182-7
All references(61)
Other
accession IDs
MGI:1917588, MGI:2139663, MGI:2384807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory