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Cth
Gene Detail
Symbol

Name
ID
Cth
cystathionase (cystathionine gamma-lyase)
MGI:1339968
Synonyms
0610010I13Rik, CSE, MGC:28655
Feature Type
protein coding gene
Genetic Map
Chromosome 3
81.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:157894248-157925077 bp, - strand
From VEGA annotation of GRCm38

  30830 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: cystathionine gamma-synthase
Gene Tree: Cth

Human
homologs
Human Homolog CTH, cystathionine gamma-lyase
NCBI Gene ID 1491
neXtProt AC  NX_P32929
Human Chr (Location)  1p31.1; chr1:70411218-70439851 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CTH
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(12) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit hypertension associated with impaired endothelium-dependent vasorelaxation. Mice homozygous for another knock-out allele exhibit normal blood pressure but sensitivty to a low cysteine diet.
 
Human Diseases Modeled Using Mouse Cth (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Cth interacts with 106 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cellular amino acid biosynthetic process, cysteine biosynthetic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function calmodulin binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (224)    Tissues (125)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 167
Northern blot 12
Western blot 32
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029713 (Evidence)
Ensembl Gene ModelENSMUSG00000028179 (Evidence)
Entrez Gene107869 (Evidence)
UniGene28301
DFCITC1578221
DoTSDT.490723
NIA Mouse Gene IndexU024795
EC4.4.1.1
Consensus CDS ProjectCCDS51101.1
International Mouse Knockout Project StatusCth
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029713 VEGA Gene Model | MGI Sequence Detail 30830 C57BL/6J ±  kb
transcript OTTMUST00000073720 VEGA | MGI Sequence Detail 1815 Not Applicable 
polypeptide OTTMUSP00000038207 VEGA | MGI Sequence Detail 398 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000006004 cystathionine gamma-lyase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211078 Akahoshi N, et al., Neutral aminoaciduria in cystathionine beta-synthase-deficient mice, an animal model of homocystinuria. Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1462-76
All references(67)
Disease annotation references (2)
Other
accession IDs
MGI:1917588, MGI:2139663, MGI:2384807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory