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Cth Gene Detail
Summary
  • Symbol
    Cth
  • Name
    cystathionase (cystathionine gamma-lyase)
  • Synonyms
    0610010I13Rik, CSE, MGC:28655
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339968
    NCBI Gene: 107869
Location & Maps
more
  • Sequence Map
    Chr3:157894248-157925077 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30830 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 81.55 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CTH, cystathionine gamma-lyase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CTH, cystathionine gamma-lyase
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 1491
    neXtProt AC: NX_P32929

  • Chr Location
    1p31.1; chr1:70411218-70440114 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cth mouse models; 1 with human CTH associations

Human Disease Mouse Models
       Cystathioninuria   OMIM: 219500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hypertension associated with impaired endothelium-dependent vasorelaxation. Mice homozygous for another knock-out allele exhibit normal blood pressure but sensitivty to a low cysteine diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029713 VEGA Gene Model | MGI Sequence Detail 30830 C57BL/6J ±  kb
transcript OTTMUST00000073720 VEGA | MGI Sequence Detail 1815 Not Applicable  
polypeptide OTTMUSP00000038207 VEGA | MGI Sequence Detail 398 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    134 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006004 cystathionine gamma-lyase
  • EC
  • InterPro Domains
    IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Molecular
Reagents
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  • All nucleic 78
    cDNA 78

    Microarray probesets 4
Other
Accession IDs
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MGI:1917588, MGI:2139663, MGI:2384807
References
more
  • Summaries
    All 75
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 9
    Phenotypes 39
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231348 Kuo MM, et al., MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H71-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory