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Cse1l
Gene Detail
Symbol

Name
ID
Cse1l
chromosome segregation 1-like (S. cerevisiae)
MGI:1339951
Synonyms
2610100P18Rik, Capts, Cas, Xpo2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
87.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:166906040-166946389 bp, + strand
From VEGA annotation of GRCm38

  40350 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1006  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CSE1L
Protein SuperFamily: exportin-2
Gene Tree: Cse1l

Human
homologs
CSE1L, CSE1 chromosome segregation 1-like (yeast)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1434
neXtProt AC: NX_P55060

Human Synonyms: CAS, CSE1, XPO2

Human Chr (Location): 20q13; chr20:49046246-49096960 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(44) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation die prior to E5.5 of development and are morphologically disorganized and lack identifiable structures.
 
Interactions
Cse1l interacts with 306 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process intracellular protein transport, protein transport, ...
Component cytoplasm, extracellular exosome, ...
Function protein binding, Ran GTPase binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (177)    Tissues (59)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 165
Northern blot 12
cDNA source data(159)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CSE1L ; Xenbase cse1l ; ZFIN cse1l    NEW 
Molecular
reagents
All nucleic(159) cDNA(159)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001165 (Evidence)
Ensembl Gene Model ENSMUSG00000002718 (Evidence)
Entrez Gene 110750 (Evidence)
UniGene 22417
DFCI TC1679705, TC1575470
DoTS DT.110678381, DT.101385614, DT.493621
NIA Mouse Gene Index U002844
Consensus CDS Project CCDS17092.1
International Mouse Phenotyping Consortium Status Cse1l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001165 VEGA Gene Model | MGI Sequence Detail 40350 C57BL/6J ±  kb
transcript OTTMUST00000002261 VEGA | MGI Sequence Detail 3641 Not Applicable 
polypeptide OTTMUSP00000001106 VEGA | MGI Sequence Detail 971 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(3) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(202 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR005043 CAS/CSE, C-terminal
InterPro IPR013713 Exportin/Importin, Cse1-like
InterPro IPR001494 Importin-beta, N-terminal
Protein Ontology PR:000005929 exportin-2
References
(Earliest) J:47272 de Miguel M, et al., Cellular apoptosis susceptibility gene capts maps to mouse chromosome 2. Mamm Genome. 1998 May;9(5):411-2
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(42)
Other
accession IDs
MGI:1206578, MGI:1917576, MGI:2138744

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory