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Myh8
Gene Detail
Symbol

Name
ID
Myh8
myosin, heavy polypeptide 8, skeletal muscle, perinatal
MGI:1339712
Synonyms
4832426G23Rik, MyHC-pn, Myhsp, Myhs-p
Feature Type
protein coding gene
Genetic Map
Chromosome 11
40.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:67277124-67308634 bp, + strand
From VEGA annotation of GRCm38

  31511 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MYH8
Gene Tree: Myh8

Human
homologs
MYH8, myosin, heavy chain 8, skeletal muscle, perinatal
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4626
neXtProt AC: NX_P13535

Human Synonyms: DA7, gtMHC-F, MyHC-peri, MyHC-pn

Human Chr (Location): 17p13.1; chr17:10390325-10421950 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MYH8

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Myh8 interacts with 200 markers (Mir7-1, Mir16-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process ATP metabolic process, muscle filament sliding, ...
Component cytoplasm, myosin complex, ...
Function actin binding, ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (59)    Tissues (27)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
RT-PCR 25
RNase protection 7
cDNA source data(10)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495968    NEW 
Molecular
reagents
All nucleic(25) Genomic(11) cDNA(10) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005922 (Evidence)
Ensembl Gene Model ENSMUSG00000055775 (Evidence)
Entrez Gene 17885 (Evidence)
DFCI TC1575975, TC1592716, TC1622852, TC1636667, TC1639777
DoTS DT.110519804, DT.110519843, DT.110519875, DT.91406000, DT.91426244, DT.94390317
Consensus CDS Project CCDS24857.1
International Mouse Phenotyping Consortium Status Myh8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005922 VEGA Gene Model | MGI Sequence Detail 31511 C57BL/6J ±  kb
transcript OTTMUST00000013184 VEGA | MGI Sequence Detail 6149 Not Applicable 
polypeptide OTTMUSP00000006120 VEGA | MGI Sequence Detail 1937 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(287 from dbSNP Build 137)    SNPs within 2kb including multiple locations(291)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010832 myosin-8
References
(Earliest) J:7242 Weydert A, et al., Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle. J Biol Chem. 1983 Nov 25;258(22):13867-74
(Latest) J:216142 Amann R, et al., The FgfrL1 receptor is required for development of slow muscle fibers. Dev Biol. 2014 Oct 15;394(2):228-41
All references(55)
Other
accession IDs
MGD-MRK-12758, MGD-MRK-12762, MGI:2144137, MGI:2442719, MGI:97265

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory