Myh3
Gene Detail

Symbol Name ID

Myh3 myosin, heavy polypeptide 3, skeletal muscle, embryonic MGI:1339709

Synonyms

MyHC-emb, Myhse, Myhs-e

Feature Type

protein coding gene

Genetic Map

Chromosome 11

40.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:67078300-67102286 bp, + strand From VEGA annotation of GRCm38   23987 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20553  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Myh3

Human homologs

Human Homolog		MYH3, myosin, heavy chain 3, skeletal muscle, embryonic
NCBI Gene ID		4621
neXtProt AC		NX_P11055
Human Synonyms		HEMHC, MYHC-EMB, MYHSE1, SMHCE
Human Chr (Location)		17p13.1; chr17:10531843-10560626 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MYH3

Alleles and phenotypes

All alleles(3) : Targeted(3)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Component	contractile fiber, cytoplasm, ...
Function	actin binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (176)    Tissues (29)    Images (31)
Theiler Stages: 16, 18, 19, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	135
Northern blot	6
RT-PCR	24
RNase protection	7

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(4) cDNA(27) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005920 (Evidence)
Ensembl Gene Model	ENSMUSG00000020908 (Evidence)
Entrez Gene	17883 (Evidence)
UniGene	340090
DFCI	TC1668632
NIA Mouse Gene Index	U012777
Consensus CDS Project	CCDS36184.1
International Mouse Knockout Project Status	Myh3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005920	VEGA Gene Model | MGI Sequence Detail	23987	C57BL/6J
transcript	OTTMUST00000013182	VEGA | MGI Sequence Detail	6031	Not Applicable
polypeptide	OTTMUSP00000006118	VEGA | MGI Sequence Detail	1940	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(167 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR015650	Myosin class 1/2/3/4/7/8/13/15
InterPro	IPR001609	Myosin head, motor domain
InterPro	IPR027401	Myosin-like IQ motif-containing domain
InterPro	IPR004009	Myosin, N-terminal, SH3-like
InterPro	IPR008989	Myosin S1 fragment, N-terminal
InterPro	IPR002928	Myosin tail
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000010827	myosin-3

References

(Earliest) J:7154 Leinwand LA, et al., Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome. Science. 1983 Aug 19;221(4612):766-9
(Latest) J:186268 Vincent SD, et al., Non Conservation of Function for the Evolutionarily Conserved Prdm1 Protein in the Control of the Slow Twitch Myogenic Program in the Mouse Embryo. Mol Biol Evol. 2012 May 13;
All references(59)

Other accession IDs

MGD-MRK-12754, MGD-MRK-12759, MGI:97262