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Myh3 Gene Detail
Summary
  • Symbol
    Myh3
  • Name
    myosin, heavy polypeptide 3, skeletal muscle, embryonic
  • Synonyms
    MyHC-emb, Myhse, Myhs-e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339709
    NCBI Gene: 17883
  • Gene Overview
    MyGene.info: MYH3
Location & Maps
more
  • Sequence Map
    Chr11:67078300-67102286 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23987 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYH3, myosin, heavy chain 3, skeletal muscle, embryonic
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MYH3, myosin, heavy chain 3, skeletal muscle, embryonic
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DA2A, DA2B, DA8, HEMHC, MYHC-EMB, MYHSE1, SMHCE
  • Links
    NCBI Gene ID: 4621
    neXtProt AC: NX_P11055

  • Chr Location
    17p13.1; chr17:10628526-10679030 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human MYH3 associations

Human Disease Mouse Models
       Arthrogryposis, Distal, Type 2A; DA2A   OMIM: 193700
Arthrogryposis, Distal, Type 2B; DA2B   OMIM: 601680
Arthrogryposis, Distal, Type 8; DA8   OMIM: 178110
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Myh3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005920 VEGA Gene Model | MGI Sequence Detail 23987 C57BL/6J ±  kb
transcript OTTMUST00000013182 VEGA | MGI Sequence Detail 6031 Not Applicable  
polypeptide OTTMUSP00000006118 VEGA | MGI Sequence Detail 1940 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    363 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    Genomic 4
    cDNA 27
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12754, MGD-MRK-12759, MGI:97262
References
more
  • Summaries
    All 62
    Developmental Gene Expression 34
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:7154 Leinwand LA, et al., Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome. Science. 1983 Aug 19;221(4612):766-9
  • Latest
    J:229482 Nagandla H, et al., Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1. Dev Biol. 2016 Feb 1;410(1):86-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory