About   Help   FAQ
Myh3 Gene Detail
Summary
  • Symbol
    Myh3
  • Name
    myosin, heavy polypeptide 3, skeletal muscle, embryonic
  • Synonyms
    MyHC-emb, Myhse, Myhs-e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339709
    NCBI Gene: 17883
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:66969126-66993112 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 40.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339709
protein coding gene Chr11:66969101-66993117 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018485
protein coding gene Chr11:67357583-67382980 (+)
A/J MGP_AJ_G0018454
protein coding gene Chr11:64832357-64859008 (+)
AKR/J MGP_AKRJ_G0018423
protein coding gene Chr11:66775662-66799842 (+)
BALB/cJ MGP_BALBcJ_G0018425
protein coding gene Chr11:65118550-65143049 (+)
C3H/HeJ MGP_C3HHeJ_G0018238
protein coding gene Chr11:66784312-66811475 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018877
protein coding gene Chr11:69390955-69417472 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016521
protein coding gene Chr11:61796237-61820470 (+)
CAST/EiJ MGP_CASTEiJ_G0017794
protein coding gene Chr11:67009685-67033682 (+)
CBA/J MGP_CBAJ_G0018212
protein coding gene Chr11:72437023-72468758 (+)
DBA/2J MGP_DBA2J_G0018321
protein coding gene Chr11:64379738-64404095 (+)
FVB/NJ MGP_FVBNJ_G0018311
protein coding gene Chr11:64041327-64067837 (+)
LP/J MGP_LPJ_G0018393
protein coding gene Chr11:67910171-67937360 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018335
protein coding gene Chr11:73266262-73292687 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018918
protein coding gene Chr11:67007636-67031556 (+)
PWK/PhJ MGP_PWKPhJ_G0017568
protein coding gene Chr11:65038685-65063473 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017358
protein coding gene Chr11:66832971-66857882 (+)
WSB/EiJ MGP_WSBEiJ_G0017847
protein coding gene Chr11:66624660-66650773 (+)



Homology
more
  • Human Ortholog
    MYH3, myosin heavy chain 3
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH3, myosin heavy chain 3
  • Synonyms
    CPSFS1A, CPSFS1B, CPSKF1A, CPSKF1B, DA2A, DA2B, DA2B3, DA8, HEMHC, MYHC-EMB, MYHSE1, SMHCE
  • Links
    NCBI Gene ID: 4621
    neXtProt AC: NX_P11055
    UniProt: P11055

  • Chr Location
    17p13.1; chr17:10628526-10678417 (-)  GRCh38

Human Diseases
more
  • Diseases
    5 with human MYH3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is partially embryonic lethal and affects myofiber size, number and type. Conditional KO at embryonic or fetal stages affects differentiation and development of myogenic precursor cells and myoblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020908 Ensembl Gene Model | MGI Sequence Detail 23987 C57BL/6J ±  kb
    transcript ENSMUST00000108689 Ensembl | MGI Sequence Detail 6031 Not Applicable  
    polypeptide ENSMUSP00000104329 Ensembl | MGI Sequence Detail 1940 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 4
      cDNA 30
      Primer pair 10
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12754, MGD-MRK-12759, MGI:97262
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 65
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:342326 Kim KH, et al., PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors. Cell Rep. 2023 Oct 24;42(11):113329

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory