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Myh3
Gene Detail
 Symbol
Name
ID
Myh3
myosin, heavy polypeptide 3, skeletal muscle, embryonic
MGI:1339709
Synonyms MyHC-emb, Myhse, Myhs-e
Feature Type protein coding gene
Genetic Map
Chromosome 11
40.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:67078300-67102286 bp, + strand
From VEGA annotation of GRCm38

  23987 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20553  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Myh3

Human
homologs
Human Homolog MYH3, myosin, heavy chain 3, skeletal muscle, embryonic
NCBI Gene ID 4621
neXtProt AC  NX_P11055
Human Synonyms  HEMHC, MYHC-EMB, MYHSE1, SMHCE
Human Chr (Location)  17p13.1; chr17:10628526-10657309 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human MYH3
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process ATP catabolic process, skeletal muscle contraction
Component contractile fiber, cytoplasm, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (193)    Tissues (35)    Images (41)
Theiler Stages: 16, 18, 19, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 152
Northern blot 6
RT-PCR 24
RNase protection 7
cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) Genomic(4) cDNA(27) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005920 (Evidence)
Ensembl Gene ModelENSMUSG00000020908 (Evidence)
Entrez Gene17883 (Evidence)
UniGene340090
DFCITC1668632
NIA Mouse Gene IndexU012777
Consensus CDS ProjectCCDS36184.1
International Mouse Knockout Project StatusMyh3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005920 VEGA Gene Model | MGI Sequence Detail 23987 C57BL/6J ±  kb
transcript OTTMUST00000013182 VEGA | MGI Sequence Detail 6031 Not Applicable 
polypeptide OTTMUSP00000006118 VEGA | MGI Sequence Detail 1940 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(363 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010827 myosin-3
References (Earliest) J:7154 Leinwand LA, et al., Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome. Science. 1983 Aug 19;221(4612):766-9
(Latest) J:206594 Daou N, et al., A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
All references(62)
Other
accession IDs
MGD-MRK-12754, MGD-MRK-12759, MGI:97262

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory