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Ogt Gene Detail
Summary
  • Symbol
    Ogt
  • Name
    O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
  • Synonyms
    1110038P24Rik, 4831420N21Rik, OGT, Ogtl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339639
    NCBI Gene: 108155
  • Gene Overview
    MyGene.info: OGT
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:101640060-101684351 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 44.45 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339639
protein coding gene ChrX:101640011-101684351 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035964
protein coding gene ChrX:98168928-98218732 (+)
A/J MGP_AJ_G0035949
protein coding gene ChrX:98156303-98202472 (+)
AKR/J MGP_AKRJ_G0035865
protein coding gene ChrX:100986403-101037145 (+)
BALB/cJ MGP_BALBcJ_G0035932
protein coding gene ChrX:96903836-96949831 (+)
C3H/HeJ MGP_C3HHeJ_G0035641
protein coding gene ChrX:98566291-98615931 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036461
protein coding gene ChrX:101082273-101130712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033291
protein coding gene ChrX:95894984-95938177 (+)
CAST/EiJ MGP_CASTEiJ_G0034928
protein coding gene ChrX:82873011-82920427 (+)
CBA/J MGP_CBAJ_G0035616
protein coding gene ChrX:104216471-104269145 (+)
DBA/2J MGP_DBA2J_G0035770
protein coding gene ChrX:97370338-97414576 (+)
FVB/NJ MGP_FVBNJ_G0035708
protein coding gene ChrX:96747188-96796591 (+)
LP/J MGP_LPJ_G0035860
protein coding gene ChrX:99116266-99163715 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035743
protein coding gene ChrX:108754393-108808246 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036488
protein coding gene ChrX:97849394-97897102 (+)
PWK/PhJ MGP_PWKPhJ_G0034627
protein coding gene ChrX:80472887-80517271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034455
protein coding gene ChrX:83789315-83839379 (+)
WSB/EiJ MGP_WSBEiJ_G0035067
protein coding gene ChrX:96558984-96602720 (+)



Homology
more
  • Human Ortholog
    OGT, O-linked N-acetylglucosamine (GlcNAc) transferase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OGT, O-linked N-acetylglucosamine (GlcNAc) transferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HINCUT-1, HRNT1, MRX106, O-GLCNAC, OGT1
  • Links
    NCBI Gene ID: 8473
    neXtProt AC: NX_O15294
    UniProt: O15294

  • Chr Location
    Xq13.1; chrX:71533062-71575897 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9675
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: OGT
  • Gene Tree
    Ogt
Human Diseases
more
  • Diseases
    1 with human OGT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Conditional deletion of this gene results in cell death in hemizygous and homozygous cells. Following germline conditional deletion only females inheriting the deletion paternally survive.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034160 Ensembl Gene Model | MGI Sequence Detail 44292 C57BL/6J ±  kb
    transcript ENSMUST00000044475 Ensembl | MGI Sequence Detail 5384 Not Applicable  
    polypeptide ENSMUSP00000045409 Ensembl | MGI Sequence Detail 1046 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011618 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    • EC
    • InterPro Domains
      IPR029489 O-GlcNAc transferase, C-terminal
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR001440 Tetratricopeptide repeat 1
      IPR013026 Tetratricopeptide repeat-containing domain
      IPR037919 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-39587, MGI:109588, MGI:1923575, MGI:1924387, MGI:2147844
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:39462 Kreppel LK, et al., Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. J Biol Chem. 1997 Apr 4;272(14):9308-15
    • Latest
      J:257889 Sodi VL, et al., Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation. Oncogene. 2018 Feb 15;37(7):924-934

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory