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Ogt
Gene Detail
 Symbol
Name
ID
Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
MGI:1339639
Synonyms 1110038P24Rik, 4831420N21Rik, OGT, Ogtl
Feature Type protein coding gene
Genetic Map
Chromosome X
44.45 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:101640060-101684351 bp, + strand
From VEGA annotation of GRCm38

  44292 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9675  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ogt

Human
homologs
Human Homolog OGT, O-linked N-acetylglucosamine (GlcNAc) transferase
NCBI Gene ID 8473
neXtProt AC  NX_O15294
Human Synonyms  HRNT1, O-GLCNAC
Human Chr (Location)  Xq13; chrX:71533062-71575897 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(8) Targeted(1)
Incidental mutations (data from Mutagenetix )
 
Conditional deletion of this gene results in cell death in hemizygous and homozygous cells. Following germline conditional deletion only females inheriting the deletion paternally survive.
 
Phenotype Images(1)
Interactions
Ogt interacts with 333 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process apoptotic process, cellular response to retinoic acid, ...
Component cytoplasm, cytosol, ...
Function catalytic activity, enzyme activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (96)    Tissues (96)    Images (21)
Theiler Stages: 22
Assay TypeResults
RNA in situ 96
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(24) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000017263 (Evidence)
Ensembl Gene ModelENSMUSG00000034160 (Evidence)
Entrez Gene108155 (Evidence)
DFCITC1571979, TC1579996, TC1584860, TC1597038, TC1607118
DoTSDT.101329371, DT.101738961, DT.101738962, DT.101738963, DT.111038816, DT.94218821, DT.94218822, DT.94218837
NIA Mouse Gene IndexU020074
EC2.4.1.94, 2.4.1.255
Consensus CDS ProjectCCDS30318.1, CCDS72415.1
International Mouse Knockout Project StatusOgt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017263 VEGA Gene Model | MGI Sequence Detail 44292 C57BL/6J ±  kb
transcript OTTMUST00000043983 VEGA | MGI Sequence Detail 5384 Not Applicable 
polypeptide OTTMUSP00000019749 VEGA | MGI Sequence Detail 1046 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000011618 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
References (Earliest) J:39462 Kreppel LK, et al., Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. J Biol Chem. 1997 Apr 4;272(14):9308-15
(Latest) J:207693 Watson LJ, et al., Cardiomyocyte Ogt is essential for postnatal viability. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H142-53
All references(55)
Other
accession IDs
MGD-MRK-39587, MGI:109588, MGI:1923575, MGI:1924387, MGI:2147844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory