St14
Gene Detail

Symbol Name ID

St14 suppression of tumorigenicity 14 (colon carcinoma) MGI:1338881

Synonyms

Epithin, matriptase, MT-SP1, Prss14, Tmprss14

Feature Type

protein coding gene

Genetic Map

Chromosome 9

16.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:31089402-31131853 bp, - strand From VEGA annotation of GRCm38   42452 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: suppressor of tumorigenicity 14
Gene Tree: St14

Human homologs

Human Homolog		ST14, suppression of tumorigenicity 14 (colon carcinoma)
NCBI Gene ID		6768
neXtProt AC		NX_Q9Y5Y6
Human Synonyms		HAI, MTSP1, MT-SP1, PRSS14, SNC19, TADG15, TMPRSS14
Human Chr (Location)		11q24-q25; chr11:130029682-130080257 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ST14

Alleles and phenotypes

All alleles(14) : Targeted(5) Gene trapped(9)
 

Homozygous inactivation of this locus results in pleiotropic defects affecting the development of the epidermis, hair follicles, and immune system. Mutant mice become dehydrated due to impaired epidermal barrier function and die within days of birth.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell migration, metabolic process, ...
Component	basolateral plasma membrane, extracellular region, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (242)    Tissues (90)    Images (31)
Theiler Stages: 1, 2, 3, 4, 5, 12, 14, 15, 19, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	155
RT-PCR	84

cDNA source data(149)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(159) cDNA(153) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029771 (Evidence)
Ensembl Gene Model	ENSMUSG00000031995 (Evidence)
Entrez Gene	19143 (Evidence)
UniGene	243926
DFCI	TC1575628
DoTS	DT.531297
NIA Mouse Gene Index	U030643
EC	3.4.21.109
Consensus CDS Project	CCDS22948.1
International Mouse Knockout Project Status	St14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029771	VEGA Gene Model | MGI Sequence Detail	42452	C57BL/6J
transcript	OTTMUST00000073883	VEGA | MGI Sequence Detail	3259	Not Applicable
polypeptide	OTTMUSP00000038298	VEGA | MGI Sequence Detail	855	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(428 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000859	CUB
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR017051	Peptidase S1A, matripase
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR000082	SEA
Protein Ontology	PR:000015678	suppressor of tumorigenicity protein 14

References

(Earliest) J:54857 Kim MG, et al., Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains. Immunogenetics. 1999 May;49(5):420-8
(Latest) J:188121 Szabo R, et al., Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency-Associated Developmental Defects by Preventing Matriptase Activation. PLoS Genet. 2012 Aug;8(8):e1002937
All references(61)