About   Help   FAQ
St14
Gene Detail
Symbol

Name
ID
St14
suppression of tumorigenicity 14 (colon carcinoma)
MGI:1338881
Synonyms
Epithin, matriptase, MT-SP1, Prss14, Tmprss14
Feature Type
protein coding gene
Genetic Map
Chromosome 9
16.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:31089402-31131853 bp, - strand
From VEGA annotation of GRCm38

  42452 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ST14
Protein SuperFamily: suppressor of tumorigenicity 14
Gene Tree: St14

Human
homologs
ST14, suppression of tumorigenicity 14 (colon carcinoma)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6768
neXtProt AC: NX_Q9Y5Y6

Human Synonyms: ARCI11, HAI, MTSP1, MT-SP1, PRSS14, SNC19, TADG15, TMPRSS14

Human Chr (Location): 11q24-q25; chr11:130159787-130210362 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this locus results in pleiotropic defects affecting the development of the epidermis, hair follicles, and immune system. Mutant mice become dehydrated due to impaired epidermal barrier function and die within days of birth.
 
Human Diseases Modeled in Mice Using St14 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
St14 interacts with 147 markers (Mir7-1, Mir16-1, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (230)    Tissues (84)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 155
RT-PCR 72
cDNA source data(149)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase st14 ; ZFIN st14a    NEW 
Molecular
reagents
All nucleic(159) cDNA(153) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029771 (Evidence)
Ensembl Gene Model ENSMUSG00000031995 (Evidence)
Entrez Gene 19143 (Evidence)
UniGene 243926
DFCI TC1575628
DoTS DT.531297
NIA Mouse Gene Index U030643
EC 3.4.21.109
Consensus CDS Project CCDS22948.1
International Mouse Phenotyping Consortium Status St14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029771 VEGA Gene Model | MGI Sequence Detail 42452 C57BL/6J ±  kb
transcript OTTMUST00000073883 VEGA | MGI Sequence Detail 3259 Not Applicable 
polypeptide OTTMUSP00000038298 VEGA | MGI Sequence Detail 855 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(460 from dbSNP Build 137)    SNPs within 2kb including multiple locations(462)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001254 Peptidase S1
InterPro IPR017051 Peptidase S1A, matripase
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000082 SEA domain
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000015678 suppressor of tumorigenicity 14 protein
References
(Earliest) J:54857 Kim MG, et al., Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains. Immunogenetics. 1999 May;49(5):420-8
(Latest) J:222717 Zoratti GL, et al., Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun. 2015;6:6776
All references(64)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory