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P2rx4
Gene Detail
 Symbol
Name
ID
P2rx4
purinergic receptor P2X, ligand-gated ion channel 4
MGI:1338859
Synonyms D5Ertd444e, P2X4
Feature Type protein coding gene
Genetic Map
Chromosome 5
62.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:122707584-122729738 bp, + strand
From VEGA annotation of GRCm38

  22155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1923  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: P2X purinoceptor
Gene Tree: P2rx4

Human
homologs
Human Homolog P2RX4, purinergic receptor P2X, ligand-gated ion channel, 4
NCBI Gene ID 5025
neXtProt AC  NX_Q99571
Human Synonyms  P2X4, P2X4R
Human Chr (Location)  12q24.32; chr12:121209861-121234106 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in hypertension, abnormal artery morphology, abnormal nitric oxide homeostasis, and impaired flow induced vascular remodeling and vasodilation.
 
Interactions
P2rx4 interacts with 218 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process apoptotic signaling pathway, calcium ion transport, ...
Component apical part of cell, axon, ...
Function ATP binding, cadherin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (137)    Tissues (40)    Images (31)
Theiler Stages: 19, 23, 25, 28
Assay TypeResults
RNA in situ 134
RT-PCR 3
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021392 (Evidence)
Ensembl Gene ModelENSMUSG00000029470 (Evidence)
Entrez Gene18438 (Evidence)
DFCITC1575560, TC1590240, TC1596260, TC1606233, TC1672721
DoTSDT.101247702, DT.87068796, DT.91447987, DT.91447988, DT.94266352, DT.94396299
NIA Mouse Gene IndexU006149
Consensus CDS ProjectCCDS19654.2
International Mouse Knockout Project StatusP2rx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021392 VEGA Gene Model | MGI Sequence Detail 22155 C57BL/6J ±  kb
transcript OTTMUST00000050713 VEGA | MGI Sequence Detail 2662 Not Applicable 
polypeptide OTTMUSP00000023741 VEGA | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(10) UniProt(10)
Polymorphisms SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003047 P2X4 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012191 P2X purinoceptor 4
References (Earliest) J:52365 Townsend-Nicholson A, et al., Molecular cloning, functional characterization and possible cooperativity between the murine P2X4 and P2X4a receptors. Brain Res Mol Brain Res. 1999 Feb 5;64(2):246-54
(Latest) J:207990 Lalo U, et al., Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex. PLoS Biol. 2014 Jan;12(1):e1001747
All references(61)
Other
accession IDs
MGI:1196264, MGI:2140926, MGI:2141234

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory