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Ap4b1
Gene Detail
 Symbol
Name
ID
Ap4b1
adaptor-related protein complex AP-4, beta 1
MGI:1337130
Synonyms 1810038H16Rik, AP-4 beta-4
Feature Type protein coding gene
Genetic Map
Chromosome 3
45.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:103809520-103822025 bp, + strand
From VEGA annotation of GRCm38

  12506 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adaptor protein complex, beta subunit
Gene Tree: Ap4b1

Human
homologs
Human Homolog AP4B1, adaptor-related protein complex 4, beta 1 subunit
NCBI Gene ID 10717
neXtProt AC  NX_Q9Y6B7
Human Synonyms  BETA-4, CPSQ5, SPG47
Human Chr (Location)  1p13.2; chr1:113894748-113905119 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AP4B1
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Gene trapped(1)
 
Mice homozygous for a null allele exhibit poor rotarod performance.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process intracellular protein transport, protein transport, ...
Component clathrin adaptor complex, coated pit, ...
Function protein transporter activity
External Resources: FuncBase
Expression
cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(39) cDNA(39)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022451 (Evidence)
Ensembl Gene ModelENSMUSG00000032952 (Evidence)
Entrez Gene67489 (Evidence)
UniGene197568
DFCITC1576850, TC1676853
Consensus CDS ProjectCCDS17696.1, CCDS51026.1
International Mouse Knockout Project StatusAp4b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022451 VEGA Gene Model | MGI Sequence Detail 12506 C57BL/6J ±  kb
transcript OTTMUST00000053682 VEGA | MGI Sequence Detail 2692 Not Applicable 
polypeptide OTTMUSP00000025538 VEGA | MGI Sequence Detail 738 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(18) UniProt(8)
Polymorphisms SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016342 AP-1, 2,4 complex subunit beta
InterPro IPR026739 AP complex subunit beta
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR012295 Beta2-adaptin/TBP, C-terminal domain
InterPro IPR015151 Beta-adaptin appendage, C-terminal subdomain
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
Protein Ontology PR:000004111 AP-4 complex subunit beta-1
References (Earliest) J:48443 Odorizzi G, et al., The AP-3 complex: a coat of many colours. Trends Cell Biol. 1998 Jul;8(7):282-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:1914739, MGI:2139923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory