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Trp73 Gene Detail
Summary
  • Symbol
    Trp73
  • Name
    transformation related protein 73
  • Synonyms
    deltaNp73, p73, TAp73
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336991
    NCBI Gene: 22062
  • Gene Overview
    MyGene.info: TP73
Location & Maps
more
  • Sequence Map
    Chr4:154056253-154140208 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83956 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TP73, tumor protein p73
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TP73, tumor protein p73
    Orthology source: HomoloGene
  • Synonyms
    P73
  • Links
    NCBI Gene ID: 7161
    neXtProt AC: NX_O15350

  • Chr Location
    1p36.3; chr1:3652565-3736201 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3960
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TP73
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Trp73 mouse models

Human Disease Mouse Models
       Otitis Media, Susceptibility to   OMIM: 166760 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 4 alleles in 6 genetic backgrounds
    21 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    1
  • Targeted
    10
  • Genomic Mutations
    3 involving Trp73
  • Incidental Mutations
Homozygous mutant mice display a variety of defects including hippocampal dysgenesis, hydrocephalus, chronic infections and inflammation, abnormal pheromone sensory pathways, eye abnormalities, impaired growth, and female infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010497 VEGA Gene Model | MGI Sequence Detail 83956 C57BL/6J ±  kb
transcript OTTMUST00000024473 VEGA | MGI Sequence Detail 5042 Not Applicable  
polypeptide OTTMUSP00000011255 VEGA | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    538 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR011615 p53, DNA-binding domain
    IPR008967 p53-like transcription factor, DNA-binding
    IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
    IPR010991 p53, tetramerisation domain
    IPR002117 p53 tumour suppressor family
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
    IPR032646 Tumour protein p73
Molecular
Reagents
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  • All nucleic 25
    Genomic 1
    cDNA 18
    Primer pair 4
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 127
    Developmental Gene Expression 34
    Diseases 1
    Gene Ontology 18
    Phenotypes 52
  • Earliest
    J:54538 Herranz M, et al., Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas. Cancer Res. 1999 May 1;59(9):2068-71
  • Latest
    J:221658 Vithayathil J, et al., Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation. J Neurosci. 2015 Apr 29;35(17):6836-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory