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Trp73
Gene Detail
Symbol

Name
ID
Trp73
transformation related protein 73
MGI:1336991
Synonyms
deltaNp73, p73, TAp73
Feature Type
protein coding gene
Genetic Map
Chromosome 4
83.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:154056253-154140208 bp, - strand
From VEGA annotation of GRCm38

  83956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TP73
Gene Tree: Trp73

Human
homologs
TP73, tumor protein p73
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7161
neXtProt AC: NX_O15350

Human Synonyms: P73

Human Chr (Location): 1p36.3; chr1:3652565-3736201 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Genomic Mutations involving Trp73 (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice display a variety of defects including hippocampal dysgenesis, hydrocephalus, chronic infections and inflammation, abnormal pheromone sensory pathways, eye abnormalities, impaired growth, and female infertility.
 
Human Diseases Modeled in Mice Using Trp73 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Trp73 interacts with 232 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process activation of MAPK activity, apoptotic process, ...
Component cell junction, chromatin, ...
Function chromatin binding, damaged DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (158)    Tissues (36)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 144
Western blot 6
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tp73    NEW 
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(18) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010497 (Evidence)
Ensembl Gene Model ENSMUSG00000029026 (Evidence)
Entrez Gene 22062 (Evidence)
UniGene 78015
DFCI TC1585991, TC1601753
DoTS DT.110830802, DT.40171146, DT.91446734, DT.91579195
NIA Mouse Gene Index U025852
Consensus CDS Project CCDS19009.2, CCDS51396.1, CCDS51397.1
International Mouse Phenotyping Consortium Status Trp73
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010497 VEGA Gene Model | MGI Sequence Detail 83956 C57BL/6J ±  kb
transcript OTTMUST00000024473 VEGA | MGI Sequence Detail 5042 Not Applicable 
polypeptide OTTMUSP00000011255 VEGA | MGI Sequence Detail 638 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(14) UniProt(6)
Polymorphisms
PCR(4) : SNPs within 2kb(548 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011615 p53, DNA-binding domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
InterPro IPR010991 p53, tetramerisation domain
InterPro IPR002117 p53 tumour suppressor family
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000016568 tumor protein p73
References
(Earliest) J:54538 Herranz M, et al., Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas. Cancer Res. 1999 May 1;59(9):2068-71
(Latest) J:221658 Vithayathil J, et al., Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation. J Neurosci. 2015 Apr 29;35(17):6836-48
All references(125)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory