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Trp73 Gene Detail
Summary
  • Symbol
    Trp73
  • Name
    transformation related protein 73
  • Synonyms
    deltaNp73, p73, TAp73
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336991
    NCBI Gene: 22062
  • Gene Overview
    MyGene.info: TP73
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:154056253-154140208 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83956 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.79 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TP73, tumor protein p73
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TP73, tumor protein p73
    Orthology source: HGNC, HomoloGene
  • Synonyms
    P73
  • Links
    NCBI Gene ID: 7161
    neXtProt AC: NX_O15350
    UniProt: O15350

  • Chr Location
    1p36.32; chr1:3652565-3736201 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3960
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TP73
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Trp73 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 4 alleles in 6 genetic backgrounds
    21 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice display a variety of defects including hippocampal dysgenesis, hydrocephalus, chronic infections and inflammation, abnormal pheromone sensory pathways, eye abnormalities, impaired growth, and female infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010497 VEGA Gene Model | MGI Sequence Detail 83956 C57BL/6J ±  kb
    transcript OTTMUST00000024473 VEGA | MGI Sequence Detail 5042 Not Applicable  
    polypeptide OTTMUSP00000011255 VEGA | MGI Sequence Detail 638 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      538 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR011615 p53, DNA-binding domain
      IPR036674 p53-like tetramerisation domain superfamily
      IPR008967 p53-like transcription factor, DNA-binding
      IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
      IPR010991 p53, tetramerisation domain
      IPR002117 p53 tumour suppressor family
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR032646 Tumour protein p73
      IPR037612 Tumour protein p73, SAM domain
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 19
      Primer pair 4
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 17
      Phenotypes 61
    • Earliest
      J:54538 Herranz M, et al., Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas. Cancer Res. 1999 May 1;59(9):2068-71
    • Latest
      J:262096 Johnson JA, et al., Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Biol Open. 2018 Apr 16;7(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory