Trp73
Gene Detail

Symbol Name ID

Trp73 transformation related protein 73 MGI:1336991

Synonyms

p73

Feature Type

protein coding gene

Genetic Map

Chromosome 4

83.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:154056253-154140208 bp, - strand From VEGA annotation of GRCm38   83956 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Trp73

Human homologs

Human Homolog		TP73, tumor protein p73
NCBI Gene ID		7161
neXtProt AC		NX_O15350
Human Synonyms		P73
Human Chr (Location)		1p36.3; chr1:3569129-3652765 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous mutant mice display a variety of defects including hippocampal dysgenesis, hydrocephalus, chronic infections and inflammation, abnormal pheromone sensory pathways, eye abnormalities, impaired growth, and female infertility.

 
Human Diseases Modeled Using Mouse Trp73 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (64 annotations)

Process	activation of MAPK activity, apoptotic process, ...
Component	chromatin, cytoplasm, ...
Function	chromatin binding, damaged DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (144)    Tissues (31)    Images (25)
Theiler Stages: 20, 23, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	140
Western blot	2

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(18) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010497 (Evidence)
Ensembl Gene Model	ENSMUSG00000029026 (Evidence)
Entrez Gene	22062 (Evidence)
UniGene	78015
DFCI	TC1585991, TC1601753
DoTS	DT.110830802, DT.40171146, DT.91446734, DT.91579195
NIA Mouse Gene Index	U025852
Consensus CDS Project	CCDS19009.2, CCDS51396.1, CCDS51397.1
International Mouse Knockout Project Status	Trp73

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010497	VEGA Gene Model | MGI Sequence Detail	83956	C57BL/6J
transcript	OTTMUST00000024473	VEGA | MGI Sequence Detail	5042	Not Applicable
polypeptide	OTTMUSP00000011255	VEGA | MGI Sequence Detail	638	Not Applicable

All sequences(60) RefSeq(6) UniProt(5)

Polymorphisms

PCR(4) : SNPs(431 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011615	p53, DNA-binding domain
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain
InterPro	IPR010991	p53, tetramerisation domain
InterPro	IPR002117	p53 tumour suppressor family
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011510	Sterile alpha motif, type 2
Protein Ontology	PR:000016568	tumor protein p73

References

(Earliest) J:54538 Herranz M, et al., Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas. Cancer Res. 1999 May 1;59(9):2068-71
(Latest) J:187743 Rufini A, et al., TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev. 2012 Sep 15;26(18):2009-14
All references(106)