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Kcnmb1
Gene Detail
 Symbol
Name
ID
Kcnmb1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
MGI:1334203
Synonyms BKbeta1, BK channel beta subunit
Feature Type protein coding gene
Genetic Map
Chromosome 11
19.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:33963013-33973641 bp, + strand
From VEGA annotation of GRCm38

  10629 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: calcium-activated potassium channel, beta subunit
Gene Tree: Kcnmb1

Human
homologs
Human Homolog KCNMB1, potassium large conductance calcium-activated channel, subfamily M, beta member 1
NCBI Gene ID 3779
neXtProt AC  NX_Q16558
Human Synonyms  BKbeta1, hbeta1, hslo-beta, K(VCA)beta, k(VCA)beta-1, SLO-BETA, slo-beta-1
Human Chr (Location)  5q34; chr5:170378161-170389677 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCNMB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in increased blood pressure, and impaired motor coordination and cerebellar function.
 
Interactions
Kcnmb1 interacts with 292 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function calcium-activated potassium channel activity, potassium channel regulator activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (168)    Tissues (24)    Images (25)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 168
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005401 (Evidence)
Ensembl Gene ModelENSMUSG00000020155 (Evidence)
Entrez Gene16533 (Evidence)
UniGene6206
DFCITC1587297, TC1604758, TC1628543
DoTSDT.40172425, DT.87048050
NIA Mouse Gene IndexU012449
Consensus CDS ProjectCCDS24538.1
International Mouse Knockout Project StatusKcnmb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005401 VEGA Gene Model | MGI Sequence Detail 10629 C57BL/6J ±  kb
transcript OTTMUST00000012040 VEGA | MGI Sequence Detail 4191 Not Applicable 
polypeptide OTTMUSP00000005580 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003930 Potassium channel, calcium-activated, BK, beta subunit
Protein Ontology PR:000009266 calcium-activated potassium channel subunit beta-1
References (Earliest) J:52303 Jiang Z, et al., Human and rodent MaxiK channel beta-subunit genes: cloning and characterization. Genomics. 1999 Jan 1;55(1):57-67
(Latest) J:198209 Scornik FS, et al., DiBAC4(3) hits a "sweet spot" for the activation of arterial large-conductance Ca2+-activated potassium channels independently of the beta1-subunit. Am J Physiol Heart Circ Physiol. 2013 Jun;304(11):H1471-82
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory