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Kcnmb1
Gene Detail
Symbol

Name
ID
Kcnmb1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
MGI:1334203
Synonyms
BKbeta1, BK channel beta subunit
Feature Type
protein coding gene
Genetic Map
Chromosome 11
19.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:33963013-33973641 bp, + strand
From VEGA annotation of GRCm38

  10629 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: KCNMB1
Protein SuperFamily: calcium-activated potassium channel, beta subunit
Gene Tree: Kcnmb1

Human
homologs
KCNMB1, potassium channel subfamily M regulatory beta subunit 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3779
neXtProt AC: NX_Q16558

Human Synonyms: BKbeta1, hbeta1, hslo-beta, K(VCA)beta, k(VCA)beta-1, SLO-BETA, slo-beta-1

Human Chr (Location): 5q34; chr5:170378161-170389677 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in increased blood pressure, and impaired motor coordination and cerebellar function.
 
Interactions
Kcnmb1 interacts with 291 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (168)    Tissues (24)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnmb1    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005401 (Evidence)
Ensembl Gene Model ENSMUSG00000020155 (Evidence)
Entrez Gene 16533 (Evidence)
UniGene 6206
DFCI TC1587297, TC1604758, TC1628543
DoTS DT.40172425, DT.87048050
NIA Mouse Gene Index U012449
Consensus CDS Project CCDS24538.1
International Mouse Phenotyping Consortium Status Kcnmb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005401 VEGA Gene Model | MGI Sequence Detail 10629 C57BL/6J ±  kb
transcript OTTMUST00000012040 VEGA | MGI Sequence Detail 4191 Not Applicable 
polypeptide OTTMUSP00000005580 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003930 Potassium channel, calcium-activated, BK, beta subunit
Protein Ontology PR:000009266 calcium-activated potassium channel subunit beta-1
References
(Earliest) J:52303 Jiang Z, et al., Human and rodent MaxiK channel beta-subunit genes: cloning and characterization. Genomics. 1999 Jan 1;55(1):57-67
(Latest) J:220350 Son Y, et al., 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels. Biochem Biophys Res Commun. 2015 Feb 13;457(3):324-7
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory