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Kcnmb1 Gene Detail
Summary
  • Symbol
    Kcnmb1
  • Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 1
  • Synonyms
    BKbeta1, BK channel beta subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334203
    NCBI Gene: 16533
  • Gene Overview
    MyGene.info: KCNMB1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:33963013-33973641 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 19.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334203
protein coding gene Chr11:33962946-33973641 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018148
protein coding gene Chr11:32295797-32306413 (+)
A/J MGP_AJ_G0018121
protein coding gene Chr11:31066602-31077244 (+)
AKR/J MGP_AKRJ_G0018085
protein coding gene Chr11:32030184-32040815 (+)
BALB/cJ MGP_BALBcJ_G0018090
protein coding gene Chr11:31246137-31256747 (+)
C3H/HeJ MGP_C3HHeJ_G0017903
protein coding gene Chr11:31980921-31991533 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018544
protein coding gene Chr11:33329522-33340162 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016199
protein coding gene Chr11:29551875-29562864 (+)
CAST/EiJ MGP_CASTEiJ_G0017467
protein coding gene Chr11:32089069-32099747 (+)
CBA/J MGP_CBAJ_G0017876
protein coding gene Chr11:34985941-34996546 (+)
DBA/2J MGP_DBA2J_G0017986
protein coding gene Chr11:30834155-30844761 (+)
FVB/NJ MGP_FVBNJ_G0017980
protein coding gene Chr11:30656848-30667534 (+)
LP/J MGP_LPJ_G0018058
protein coding gene Chr11:32567953-32578595 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018004
protein coding gene Chr11:35883375-35894013 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018583
protein coding gene Chr11:32188233-32198883 (+)
PWK/PhJ MGP_PWKPhJ_G0017248
protein coding gene Chr11:31024725-31035491 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017040
protein coding gene Chr11:31920989-31932216 (+)
WSB/EiJ MGP_WSBEiJ_G0017516
protein coding gene Chr11:31821020-31831610 (+)



Homology
more
  • Human Ortholog
    KCNMB1, potassium calcium-activated channel subfamily M regulatory beta subunit 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KCNMB1, potassium calcium-activated channel subfamily M regulatory beta subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BKbeta1, hbeta1, hslo-beta, K(VCA)beta, k(VCA)beta-1, SLO-BETA, slo-beta-1
  • Links
    NCBI Gene ID: 3779
    neXtProt AC: NX_Q16558
    UniProt: Q16558

  • Chr Location
    5q35.1; chr5:170378161-170389677 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased blood pressure, and impaired motor coordination and cerebellar function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020155 Ensembl Gene Model | MGI Sequence Detail 10629 C57BL/6J ±  kb
    transcript ENSMUST00000020362 Ensembl | MGI Sequence Detail 4191 Not Applicable  
    polypeptide ENSMUSP00000020362 Ensembl | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR003930 Potassium channel, calcium-activated, BK, beta subunit
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264251 Barnes EA, et al., beta1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L265-L275

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory