Slc22a3
Gene Detail

Symbol Name ID

Slc22a3 solute carrier family 22 (organic cation transporter), member 3 MGI:1333817

Synonyms

EMT, Oct3, Orct3

Feature Type

protein coding gene

Genetic Map

Chromosome 17

8.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:12419972-12507704 bp, - strand From NCBI annotation of GRCm38   87733 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22630  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc22a3

Human homologs

Human Homolog		SLC22A3, solute carrier family 22 (extraneuronal monoamine transporter), member 3
NCBI Gene ID		6581
neXtProt AC		NX_O75751
Human Synonyms		EMT, EMTH, OCT3
Human Chr (Location)		6q25.3; chr6:160769405-160873611 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit increased susceptibility to paraquat-induced dopamine neuron neurotoxicity.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	dopamine transport, histamine transport, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	dopamine transmembrane transporter activity, ion transmembrane transporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (107)    Tissues (24)    Images (25)
Theiler Stages: 11, 20, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	55
Northern blot	43
RT-PCR	9

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(6) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023828 (Evidence)
Entrez Gene	20519 (Evidence)
UniGene	99252
DFCI	TC1587535
DoTS	DT.524760, DT.55266042
NIA Mouse Gene Index	U037424
Consensus CDS Project	CCDS28391.1
International Mouse Knockout Project Status	Slc22a3

Sequences

Length	Strain/Species
genomic	20519	NCBI Gene Model | MGI Sequence Detail	87733	C57BL/6J
transcript	NM_011395	RefSeq | MGI Sequence Detail	3501	C57BL/6
polypeptide	Q9WTW5	UniProt | EBI | MGI Sequence Detail	551	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(131 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005828	General substrate transporter
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR004749	Organic cation transport protein
InterPro	IPR005829	Sugar transporter, conserved site
Protein Ontology	PR:000014990	solute carrier family 22 member 3

Graphical View of Protein Domain Structure

References

(Earliest) J:52875 Verhaagh S, et al., Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics. 1999 Jan 15;55(2):209-18
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(43)