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Ccs
Gene Detail
Symbol

Name
ID
Ccs
copper chaperone for superoxide dismutase
MGI:1333783
Synonyms
CCS, Ccsd
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:4825366-4839322 bp, - strand
From NCBI annotation of GRCm38

  13957 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3762  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: copper chaperone for superoxide dismutase
Gene Tree: Ccs

Human
homologs
Human Homolog CCS, copper chaperone for superoxide dismutase
NCBI Gene ID 9973
neXtProt AC  NX_O14618
Human Chr (Location)  11q13; chr11:66593159-66606019 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Gene trapped(42) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased sensitivity to paraquat and reduced female fertility. Ovaries of mutant female animals have reduced numbers of mature ovarian follicles and corpora lutea.
 
Interactions
Ccs interacts with 15 markers (Mir18, Mir32, Mir187, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process metal ion transport, oxidation-reduction process, ...
Component cytoplasm, nucleus
Function copper ion binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) cDNA(67) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000034108 (Evidence)
Entrez Gene12460 (Evidence)
UniGene434411
DFCITC1577450
DoTSDT.533803, DT.99848316
NIA Mouse Gene IndexU019075
Consensus CDS ProjectCCDS29438.1
International Mouse Knockout Project StatusCcs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12460 NCBI Gene Model | MGI Sequence Detail 13957 C57BL/6J ±  kb
transcript NM_016892 RefSeq | MGI Sequence Detail 1057 C57BL/6 
polypeptide Q9WU84 UniProt | EBI | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006121 Heavy metal-associated domain, HMA
InterPro IPR001424 Superoxide dismutase, copper/zinc binding domain
InterPro IPR018152 Superoxide dismutase, copper/zinc, binding site
Protein Ontology PR:000005147 copper chaperone for superoxide dismutase
Graphical View of Protein Domain Structure
References
(Earliest) J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
(Latest) J:179996 Lassi KC, et al., Erythrocyte Copper Chaperone for Superoxide Dismutase Is Increased following Marginal Copper Deficiency in Adult and Postweanling Mice. J Nutr. 2012 Feb;142(2):292-7
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory