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Ccs Gene Detail
Summary
  • Symbol
    Ccs
  • Name
    copper chaperone for superoxide dismutase
  • Synonyms
    CCS, Ccsd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333783
    NCBI Gene: 12460
  • Gene Overview
    MyGene.info: CCS
Location & Maps
more
  • Sequence Map
    Chr19:4825366-4839322 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13957 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.11 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CCS, copper chaperone for superoxide dismutase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CCS, copper chaperone for superoxide dismutase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 9973
    neXtProt AC: NX_O14618

  • Chr Location
    11q13; chr11:66593162-66606019 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    46
  • Gene trapped
    42
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
Homozygous mutation of this gene results in increased sensitivity to paraquat and reduced female fertility. Ovaries of mutant female animals have reduced numbers of mature ovarian follicles and corpora lutea.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034108 Ensembl Gene Model | MGI Sequence Detail 13957 C57BL/6J ±  kb
transcript ENSMUST00000037246 Ensembl | MGI Sequence Detail 1057 Not Applicable  
polypeptide ENSMUSP00000035486 Ensembl | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    88 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005147 copper chaperone for superoxide dismutase
  • InterPro Domains
    IPR006121 Heavy metal-associated domain, HMA
    IPR024142 Superoxide dismutase 1 copper chaperone
    IPR001424 Superoxide dismutase, copper/zinc binding domain
    IPR018152 Superoxide dismutase, copper/zinc, binding site
    IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
Molecular
Reagents
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  • All nucleic 68
    cDNA 67
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
  • Latest
    J:179996 Lassi KC, et al., Erythrocyte Copper Chaperone for Superoxide Dismutase Is Increased following Marginal Copper Deficiency in Adult and Postweanling Mice. J Nutr. 2012 Feb;142(2):292-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory