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Ccs
Gene Detail
Symbol

Name
ID
Ccs
copper chaperone for superoxide dismutase
MGI:1333783
Synonyms
CCS, Ccsd
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:4825366-4839322 bp, - strand
From Ensembl annotation of GRCm38

  13957 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3762  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCS
Protein SuperFamily: copper chaperone for superoxide dismutase
Gene Tree: Ccs

Human
homologs
CCS, copper chaperone for superoxide dismutase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9973
neXtProt AC: NX_O14618

Human Chr (Location): 11q13; chr11:66593162-66606019 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(42) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased sensitivity to paraquat and reduced female fertility. Ovaries of mutant female animals have reduced numbers of mature ovarian follicles and corpora lutea.
 
Interactions
Ccs interacts with 15 markers (Mir18, Mir32, Mir187, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process metal ion transport, oxidation-reduction process, ...
Component cytoplasm, nucleus
Function copper ion binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(67)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ccs ; ZFIN ccs    NEW 
Molecular
reagents
All nucleic(68) cDNA(67) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000034108 (Evidence)
Entrez Gene 12460 (Evidence)
UniGene 434411
DFCI TC1577450
DoTS DT.533803, DT.99848316
NIA Mouse Gene Index U019075
Consensus CDS Project CCDS29438.1
International Mouse Phenotyping Consortium Status Ccs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034108 Ensembl Gene Model | MGI Sequence Detail 13957 C57BL/6J ±  kb
transcript ENSMUST00000037246 Ensembl | MGI Sequence Detail 1057 Not Applicable 
polypeptide ENSMUSP00000035486 Ensembl | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006121 Heavy metal-associated domain, HMA
InterPro IPR001424 Superoxide dismutase, copper/zinc binding domain
InterPro IPR018152 Superoxide dismutase, copper/zinc, binding site
Protein Ontology PR:000005147 copper chaperone for superoxide dismutase
References
(Earliest) J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
(Latest) J:179996 Lassi KC, et al., Erythrocyte Copper Chaperone for Superoxide Dismutase Is Increased following Marginal Copper Deficiency in Adult and Postweanling Mice. J Nutr. 2012 Feb;142(2):292-7
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory