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Masp2 Gene Detail
Summary
  • Symbol
    Masp2
  • Name
    mannan-binding lectin serine peptidase 2
  • Synonyms
    MAp19, MASP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330832
    NCBI Gene: 17175
  • Gene Overview
    MyGene.info: MASP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148602554-148615499 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.76 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330832
protein coding gene Chr4:148594904-148615499 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029128
protein coding gene Chr4:152341185-152355618 (+)
A/J MGP_AJ_G0029093
protein coding gene Chr4:146038227-146051165 (+)
AKR/J MGP_AKRJ_G0029041
protein coding gene Chr4:150010666-150025245 (+)
BALB/cJ MGP_BALBcJ_G0029109
protein coding gene Chr4:146539238-146552551 (+)
C3H/HeJ MGP_C3HHeJ_G0028830
protein coding gene Chr4:150573274-150586418 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029558
protein coding gene Chr4:157869081-157881841 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026804
protein coding gene Chr4:138454411-138468849 (+)
CAST/EiJ MGP_CASTEiJ_G0028243
protein coding gene Chr4:147781772-147793857 (+)
CBA/J MGP_CBAJ_G0028792
protein coding gene Chr4:162463984-162480198 (+)
DBA/2J MGP_DBA2J_G0028941
protein coding gene Chr4:146146631-146159506 (+)
FVB/NJ MGP_FVBNJ_G0028905
protein coding gene Chr4:145234914-145247845 (+)
LP/J MGP_LPJ_G0029031
protein coding gene Chr4:152297224-152310156 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028932
protein coding gene Chr4:165764638-165777584 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029590
protein coding gene Chr4:150503909-150521304 (+)
PWK/PhJ MGP_PWKPhJ_G0027963
protein coding gene Chr4:142132790-142146132 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027797
protein coding gene Chr4:144752880-144765873 (+)
WSB/EiJ MGP_WSBEiJ_G0028323
protein coding gene Chr4:150665881-150680509 (+)



Homology
more
  • Human Ortholog
    MASP2, mannan binding lectin serine peptidase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MASP2, mannan binding lectin serine peptidase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAP19, MASP1P1, MASP-2, sMAP
  • Links
    NCBI Gene ID: 10747
    neXtProt AC: NX_O00187
    UniProt: O00187

  • Chr Location
    1p36.22; chr1:11026523-11047239 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous disruption of the exon encoding the small mannose-binding lectin (MBL)-associated protein results in a defective lectin-mediated complement pathway with a 20% reduction in the ability of serum components to cleave C3 and C4 in the presence of mannose.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028979 Ensembl Gene Model | MGI Sequence Detail 12946 C57BL/6J ±  kb
transcript ENSMUST00000052060 Ensembl | MGI Sequence Detail 3058 Not Applicable  
polypeptide ENSMUSP00000049729 Ensembl | MGI Sequence Detail 685 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 16
    Primer pair 3

    Microarray probesets 5
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:50500 Endo Y, et al., Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates. J Immunol. 1998 Nov 1;161(9):4924-30
  • Latest
    J:251071 Banda NK, et al., Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2. J Immunol. 2017 Sep 1;199(5):1835-1845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory