Masp2
Gene Detail

Symbol Name ID

Masp2 mannan-binding lectin serine peptidase 2 MGI:1330832

Synonyms

MAp19, MASP-2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

78.76 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:148602554-148615499 bp, + strand From VEGA annotation of GRCm38   12946 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4819  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: Masp2

Human homologs

Human Homolog		MASP2, mannan-binding lectin serine peptidase 2
NCBI Gene ID		10747
neXtProt AC		NX_O00187
Human Synonyms		MAP19, MASP1P1, MASP-2, sMAP
Human Chr (Location)		1p36.3-p36.2; chr1:11086580-11107296 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MASP2

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Homozygous disruption of the exon encoding the small mannose-binding lectin (MBL)-associated protein results in a defective lectin-mediated complement pathway with a 20% reduction in the ability of serum components to cleave C3 and C4 in the presence of mannose.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	complement activation, complement activation, classical pathway, ...
Component	extracellular region
Function	calcium-dependent protein binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (15)    Tissues (11)   
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	15

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000010952 (Evidence)
Ensembl Gene Model	ENSMUSG00000028979 (Evidence)
Entrez Gene	17175 (Evidence)
NIA Mouse Gene Index	U005089
EC	3.4.21.104
Consensus CDS Project	CCDS18941.1, CCDS18942.1
International Mouse Knockout Project Status	Masp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010952	VEGA Gene Model | MGI Sequence Detail	12946	C57BL/6J
transcript	OTTMUST00000025689	VEGA | MGI Sequence Detail	3058	Not Applicable
polypeptide	OTTMUSP00000011778	VEGA | MGI Sequence Detail	685	Not Applicable

All sequences(38) RefSeq(4) UniProt(2)

Polymorphisms

PCR(1) : SNPs(261 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016060	Complement control module
InterPro	IPR000859	CUB
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000010194	mannan-binding lectin serine protease 2

References

(Earliest) J:50500 Endo Y, et al., Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates. J Immunol. 1998 Nov 1;161(9):4924-30
(Latest) J:179342 Iwaki D, et al., The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway. J Immunol. 2011 Oct 1;187(7):3751-8
All references(36)