About   Help   FAQ
Cdk9 Gene Detail
Summary
  • Symbol
    Cdk9
  • Name
    cyclin-dependent kinase 9 (CDC2-related kinase)
  • Synonyms
    PITALRE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328368
    NCBI Gene: 107951
  • Gene Overview
    MyGene.info: CDK9
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32705782-32712784 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328368
protein coding gene Chr2:32705782-32713076 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025618
protein coding gene Chr2:31189423-31199674 (-)
A/J MGP_AJ_G0025595
protein coding gene Chr2:29857966-29865937 (-)
AKR/J MGP_AKRJ_G0025565
protein coding gene Chr2:30930430-30938464 (-)
BALB/cJ MGP_BALBcJ_G0025592
protein coding gene Chr2:29978955-29986778 (-)
C3H/HeJ MGP_C3HHeJ_G0025352
protein coding gene Chr2:30810355-30821046 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026036
protein coding gene Chr2:32130300-32137710 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023445
protein coding gene Chr2:28579387-28586901 (-)
CAST/EiJ MGP_CASTEiJ_G0024814
protein coding gene Chr2:30758776-30769898 (-)
CBA/J MGP_CBAJ_G0025330
protein coding gene Chr2:33360537-33368035 (-)
DBA/2J MGP_DBA2J_G0025463
protein coding gene Chr2:29624444-29631317 (-)
FVB/NJ MGP_FVBNJ_G0025425
protein coding gene Chr2:29504491-29517768 (-)
LP/J MGP_LPJ_G0025549
protein coding gene Chr2:31062509-31070695 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025456
protein coding gene Chr2:32980728-32990036 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026094
protein coding gene Chr2:30800891-30808180 (-)
PWK/PhJ MGP_PWKPhJ_G0024562
protein coding gene Chr2:29529612-29536944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024362
protein coding gene Chr2:30958178-30965435 (-)
WSB/EiJ MGP_WSBEiJ_G0024883
protein coding gene Chr2:30980437-30989526 (-)



Homology
more
  • Human Ortholog
    CDK9, cyclin dependent kinase 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDK9, cyclin dependent kinase 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C-2k, CDC2L4, CTK1, PITALRE, TAK
  • Links
    NCBI Gene ID: 1025
    neXtProt AC: NX_P50750
    UniProt: P50750

  • Chr Location
    9q34.11; chr9:127786026-127790782 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107951 NCBI Gene Model | MGI Sequence Detail 7003 C57BL/6J ±  kb
    transcript NM_130860 RefSeq | MGI Sequence Detail 3389 C57BL/6  
    polypeptide Q99J95 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 132
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 9
      Gene Ontology 22
      Phenotypes 10
    • Earliest
      J:50128 Bagella L, et al., Cloning of murine CDK9/PITALRE and its tissue-specific expression in development. J Cell Physiol. 1998 Nov;177(2):206-13
    • Latest
      J:256201 Rollins DA, et al., Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. Nat Commun. 2017 Nov 23;8(1):1739

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory