Cdk9
Gene Detail

Symbol Name ID

Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) MGI:1328368

Synonyms

PITALRE

Feature Type

protein coding gene

Genetic Map

Chromosome 2

22.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:32705784-32713076 bp, - strand From VEGA annotation of GRCm38   7293 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk9

Human homologs

Human Homolog		CDK9, cyclin-dependent kinase 9
NCBI Gene ID		1025
neXtProt AC		NX_P50750
Human Synonyms		C-2k, CDC2L4, CTK1, PITALRE, TAK
Human Chr (Location)		9q34.1; chr9:130548305-130553052 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(3) Gene trapped(5)

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	cellular response to cytokine stimulus, DNA repair, ...
Component	cytoplasm, intracellular membrane-bounded organelle, ...
Function	ATP binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (23)   
Theiler Stages: 15, 17, 19, 28

Assay Type	Results
RNA in situ	14
Western blot	10

cDNA source data(132)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(133) cDNA(132) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000012534 (Evidence)
Ensembl Gene Model	ENSMUSG00000009555 (Evidence)
Entrez Gene	107951 (Evidence)
UniGene	27557
DFCI	TC1575385, TC1709346
DoTS	DT.101735411, DT.533908, DT.55238959
NIA Mouse Gene Index	U022507, U370087, U377781
EC	2.7.11.22, 2.7.11.23
Consensus CDS Project	CCDS15927.1
International Mouse Knockout Project Status	Cdk9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012534	VEGA Gene Model | MGI Sequence Detail	7293	C57BL/6J
transcript	OTTMUST00000029807	VEGA | MGI Sequence Detail	1733	Not Applicable
polypeptide	OTTMUSP00000013406	VEGA | MGI Sequence Detail	372	Not Applicable

All sequences(61) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005267	cyclin-dependent kinase 9

References

(Earliest) J:50128 Bagella L, et al., Cloning of murine CDK9/PITALRE and its tissue-specific expression in development. J Cell Physiol. 1998 Nov;177(2):206-13
(Latest) J:192997 Dai Q, et al., Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells. J Biol Chem. 2012 Jul 20;287(30):25344-52
All references(50)