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Cdk9
Gene Detail
Symbol

Name
ID
Cdk9
cyclin-dependent kinase 9 (CDC2-related kinase)
MGI:1328368
Synonyms
PITALRE
Feature Type
protein coding gene
Genetic Map
Chromosome 2
22.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:32705784-32713076 bp, - strand
From VEGA annotation of GRCm38

  7293 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK9
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk9

Human
homologs
CDK9, cyclin-dependent kinase 9
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1025
neXtProt AC: NX_P50750

Human Synonyms: C-2k, CDC2L4, CTK1, PITALRE, TAK

Human Chr (Location): 9q34.1; chr9:127786026-127790773 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cdk9 interacts with 205 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cellular response to cytokine stimulus, cellular response to DNA damage stimulus, ...
Component cytoplasm, intracellular membrane-bounded organelle, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
Western blot 10
cDNA source data(131)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CDK9 ; Xenbase cdk9    NEW 
Molecular
reagents
All nucleic(132) cDNA(131) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000012534 (Evidence)
Ensembl Gene Model ENSMUSG00000009555 (Evidence)
Entrez Gene 107951 (Evidence)
UniGene 27557
DFCI TC1575385, TC1709346
DoTS DT.533908, DT.101735411, DT.55238959
NIA Mouse Gene Index U377781, U370087, U022507
EC 2.7.11.23, 2.7.11.22
Consensus CDS Project CCDS15927.1
International Mouse Phenotyping Consortium Status Cdk9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012534 VEGA Gene Model | MGI Sequence Detail 7293 C57BL/6J ±  kb
transcript OTTMUST00000029807 VEGA | MGI Sequence Detail 1733 Not Applicable 
polypeptide OTTMUSP00000013406 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005267 cyclin-dependent kinase 9
References
(Earliest) J:50128 Bagella L, et al., Cloning of murine CDK9/PITALRE and its tissue-specific expression in development. J Cell Physiol. 1998 Nov;177(2):206-13
(Latest) J:210726 Salem T, et al., Chromatin loop organization of the junb locus in mouse dendritic cells. Nucleic Acids Res. 2013 Oct;41(19):8908-25
All references(57)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory