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Trex1 Gene Detail
Summary
  • Symbol
    Trex1
  • Name
    three prime repair exonuclease 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328317
    NCBI Gene: 22040
  • Gene Overview
    MyGene.info: TREX1
Location & Maps
more
  • Sequence Map
    Chr9:109057933-109059734 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1802 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TREX1, three prime repair exonuclease 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TREX1, three prime repair exonuclease 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGS1, CRV, DRN3, HERNS
  • Links
    NCBI Gene ID: 11277
    neXtProt AC: NX_Q9NSU2

  • Chr Location
    3p21.31; chr3:48465520-48467645 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Trex1 mouse models; 4 with human TREX1 associations

Human Disease Mouse Models
       Aicardi-Goutieres Syndrome 1; AGS1   OMIM: 225750 View 1 model
       Chilblain Lupus 1; CHBL1   OMIM: 610448
Systemic Lupus Erythematosus; SLE   OMIM: 152700
Vasculopathy, Retinal, with Cerebral Leukodystrophy; RVCL   OMIM: 192315
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
Homozygous null mice display a decreased life span, cardiomyopathy, myocarditis, atrial thrombosis, and abnormal spleen morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055468 VEGA Gene Model | MGI Sequence Detail 1802 C57BL/6J ±  kb
transcript OTTMUST00000048743 VEGA | MGI Sequence Detail 1084 Not Applicable  
polypeptide OTTMUSP00000022432 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    33 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143232
References
more
  • Summaries
    All 54
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:56273 Mazur DJ, et al., Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60
  • Latest
    J:229467 Zhang KK, et al., Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory