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F11r
Gene Detail
Symbol

Name
ID
F11r
F11 receptor
MGI:1321398
Synonyms
BV11 antigen, ESTM33, JAM-1, JAM-A, Jcam1, Ly106
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.43 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:171437535-171464603 bp, + strand
From VEGA annotation of GRCm38

  27069 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

HCOP human homology predictions: F11R
Gene Tree: F11r

Human
homologs
F11R, F11 receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 50848
neXtProt AC: NX_Q9Y624

Human Synonyms: CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1

Human Chr (Location): 1q21.2-q21.3; chr1:160995211-161021343 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(35) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased dendritic cell migratory ability and contact hypersensitivity.
 
Interactions
F11r interacts with 179 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process actomyosin structure organization, cell adhesion, ...
Component bicellular tight junction, cell-cell junction, ...
Function PDZ domain binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (194)    Tissues (48)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 146
In situ reporter (knock in) 1
RT-PCR 32
cDNA source data(100)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase f11r ; ZFIN f11r.1, f11r.2    NEW 
Molecular
reagents
All nucleic(108) Genomic(3) cDNA(100) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021724 (Evidence)
Ensembl Gene Model ENSMUSG00000038235 (Evidence)
Entrez Gene 16456 (Evidence)
UniGene 294882
DFCI TC1615253, TC1588638, TC1577106
DoTS DT.87072314, DT.91438187
NIA Mouse Gene Index U001089
PDB 1F97
Consensus CDS Project CCDS15496.1
International Mouse Phenotyping Consortium Status F11r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021724 VEGA Gene Model | MGI Sequence Detail 27069 C57BL/6J ±  kb
transcript OTTMUST00000051546 VEGA | MGI Sequence Detail 2518 Not Applicable 
polypeptide OTTMUSP00000024286 VEGA | MGI Sequence Detail 300 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(303 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001871 junctional adhesion molecule A
References
(Earliest) J:48708 Martin-Padura I, et al., Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol. 1998 Jul 13;142(1):117-27
(Latest) J:218178 Mitchell LA, et al., Junctional adhesion molecule a promotes epithelial tight junction assembly to augment lung barrier function. Am J Pathol. 2015 Feb;185(2):372-86
All references(82)
Other
accession IDs
MGI:1334465

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory