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F11r
Gene Detail
 Symbol
Name
ID
F11r
F11 receptor
MGI:1321398
Synonyms BV11 antigen, ESTM33, JAM-1, JAM-A, Jcam1, Ly106
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.43 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:171437535-171464603 bp, + strand
From VEGA annotation of GRCm38

  27069 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: F11r

Human
homologs
Human Homolog F11R, F11 receptor
NCBI Gene ID 50848
neXtProt AC  NX_Q9Y624
Human Synonyms  CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1
Human Chr (Location)  1q21.2-q21.3; chr1:160995211-161021343 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(35) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased dendritic cell migratory ability and contact hypersensitivity.
 
Interactions
F11r interacts with 180 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, epithelial cell differentiation, ...
Component cell-cell junction, cell junction, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (194)    Tissues (48)    Images (25)
Theiler Stages: 3, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 146
In situ reporter (knock in) 1
RT-PCR 32
cDNA source data(100)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) Genomic(3) cDNA(100) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021724 (Evidence)
Ensembl Gene ModelENSMUSG00000038235 (Evidence)
Entrez Gene16456 (Evidence)
UniGene294882
DFCITC1577106, TC1588638, TC1615253
DoTSDT.87072314, DT.91438187
NIA Mouse Gene IndexU001089
PDB1F97
Consensus CDS ProjectCCDS15496.1
International Mouse Knockout Project StatusF11r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021724 VEGA Gene Model | MGI Sequence Detail 27069 C57BL/6J ±  kb
transcript OTTMUST00000051546 VEGA | MGI Sequence Detail 2518 Not Applicable 
polypeptide OTTMUSP00000024286 VEGA | MGI Sequence Detail 300 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(303 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR003596 Immunoglobulin V-set, subgroup
Protein Ontology PR:000001871 junctional adhesion molecule A
References (Earliest) J:48708 Martin-Padura I, et al., Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol. 1998 Jul 13;142(1):117-27
(Latest) J:208709 Naik MU, et al., Junctional adhesion molecule-A suppresses platelet integrin alphaIIbbeta3 signaling by recruiting Csk to the integrin-c-Src complex. Blood. 2014 Feb 27;123(9):1393-402
All references(81)
Other
accession IDs
MGI:1334465

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory