F11r
Gene Detail

Symbol Name ID

F11r F11 receptor MGI:1321398

Synonyms

BV11 antigen, ESTM33, JAM-1, JAM-A, Jcam1, Ly106

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.43 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:171437535-171464603 bp, + strand From VEGA annotation of GRCm38   27069 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: F11r

Human homologs

Human Homolog		F11R, F11 receptor
NCBI Gene ID		50848
neXtProt AC		NX_Q9Y624
Human Synonyms		CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1
Human Chr (Location)		1q21.2-q21.3; chr1:160965001-160991133 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(39) : Targeted(4) Gene trapped(35)
 

Homozygous null mice display increased dendritic cell migratory ability and contact hypersensitivity.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell adhesion, epithelial cell differentiation, ...
Component	cell junction, integral to membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (194)    Tissues (47)    Images (25)
Theiler Stages: 3, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	15
RNA in situ	146
In situ reporter (knock in)	1
RT-PCR	32

cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(108) Genomic(3) cDNA(100) Primer pair(5)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021724 (Evidence)
Ensembl Gene Model	ENSMUSG00000038235 (Evidence)
Entrez Gene	16456 (Evidence)
UniGene	294882
DFCI	TC1577106, TC1588638, TC1615253
DoTS	DT.87072314, DT.91438187
NIA Mouse Gene Index	U001089
PDB	1F97
Consensus CDS Project	CCDS15496.1
International Mouse Knockout Project Status	F11r

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021724	VEGA Gene Model | MGI Sequence Detail	27069	C57BL/6J
transcript	OTTMUST00000051546	VEGA | MGI Sequence Detail	2518	Not Applicable
polypeptide	OTTMUSP00000024286	VEGA | MGI Sequence Detail	300	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(140 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR003596	Immunoglobulin V-set, subgroup
Protein Ontology	PR:000001871	junctional adhesion molecule A

References

(Earliest) J:48708 Martin-Padura I, et al., Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol. 1998 Jul 13;142(1):117-27
(Latest) J:187658 Khounlotham M, et al., Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis. Immunity. 2012 Sep 21;37(3):563-73
All references(75)

Other accession IDs

MGI:1334465