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Vamp3
Gene Detail
Symbol

Name
ID
Vamp3
vesicle-associated membrane protein 3
MGI:1321389
Synonyms
ceb, cellubrevin, D130027G05Rik, VAMP-3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
81.53 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:151047300-151057963 bp, - strand
From VEGA annotation of GRCm38

  10664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VAMP3
Protein SuperFamily: synaptobrevin
Gene Tree: Vamp3

Human
homologs
VAMP3, vesicle-associated membrane protein 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9341
neXtProt AC: NX_Q15836

Human Synonyms: CEB

Human Chr (Location): 1p36.23; chr1:7771269-7781432 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(3) Targeted(9)
Genomic Mutations involving Vamp3 (3)
 
Homozygotes for a targeted null mutation lack vesicle-associated membrane protein 3 but are apparently normal.
 
Interactions
Vamp3 interacts with 242 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process calcium ion-dependent exocytosis, Golgi to plasma membrane protein transport, ...
Component apical plasma membrane, cell, ...
Function protein binding, SNAP receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (13)    Tissues (8)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 2
Western blot 7
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vamp3    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000010239 (Evidence)
Ensembl Gene Model ENSMUSG00000028955 (Evidence)
Entrez Gene 22319 (Evidence)
DFCI TC1572593, TC1624816
DoTS DT.55100666, DT.91335672
NIA Mouse Gene Index U025825
Consensus CDS Project CCDS18979.1
International Mouse Phenotyping Consortium Status Vamp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010239 VEGA Gene Model | MGI Sequence Detail 10664 C57BL/6J ±  kb
transcript OTTMUST00000023797 VEGA | MGI Sequence Detail 2120 Not Applicable 
polypeptide OTTMUSP00000010900 VEGA | MGI Sequence Detail 103 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001388 Synaptobrevin
InterPro IPR016444 Synaptobrevin/Vesicle-associated membrane protein
Protein Ontology PR:000017250 vesicle-associated membrane protein 3
References
(Earliest) J:34570 Martin S, et al., The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells. J Cell Biol. 1996 Aug;134(3):625-35
(Latest) J:197107 Kato U, et al., Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. J Biol Chem. 2013 Feb 15;288(7):4922-34
All references(61)
Other
accession IDs
MGI:2444833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory