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Lpcat3 Gene Detail
Summary
  • Symbol
    Lpcat3
  • Name
    lysophosphatidylcholine acyltransferase 3
  • Synonyms
    Grcc3f, Mboat5, Oact5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315211
    NCBI Gene: 14792
  • Gene Overview
    MyGene.info: LPCAT3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124663027-124704418 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315211
protein coding gene Chr6:124663027-124704716 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031259
protein coding gene Chr6:127962954-128007976 (+)
A/J MGP_AJ_G0031229
protein coding gene Chr6:123153006-123194652 (+)
AKR/J MGP_AKRJ_G0031157
protein coding gene Chr6:126510740-126554190 (+)
BALB/cJ MGP_BALBcJ_G0031237
protein coding gene Chr6:122747663-122789488 (+)
C3H/HeJ MGP_C3HHeJ_G0030960
protein coding gene Chr6:126557839-126602739 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031693
protein coding gene Chr6:131338716-131391453 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028843
protein coding gene Chr6:120342748-120381349 (+)
CAST/EiJ MGP_CASTEiJ_G0030341
protein coding gene Chr6:126749740-126803926 (+)
CBA/J MGP_CBAJ_G0030921
protein coding gene Chr6:136375553-136422334 (+)
DBA/2J MGP_DBA2J_G0031077
protein coding gene Chr6:122077871-122121194 (+)
FVB/NJ MGP_FVBNJ_G0031027
protein coding gene Chr6:120982922-121024639 (+)
LP/J MGP_LPJ_G0031157
protein coding gene Chr6:128126983-128174936 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031065
protein coding gene Chr6:140428676-140474006 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031728
protein coding gene Chr6:126401577-126446170 (+)
PWK/PhJ MGP_PWKPhJ_G0030056
protein coding gene Chr6:120305774-120348856 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029885
protein coding gene Chr6:124474735-124521075 (+)
WSB/EiJ MGP_WSBEiJ_G0030426
protein coding gene Chr6:126756479-126802921 (+)



Homology
more
  • Human Ortholog
    LPCAT3, lysophosphatidylcholine acyltransferase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPCAT3, lysophosphatidylcholine acyltransferase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, nessy, OACT5
  • Links
    NCBI Gene ID: 10162
    neXtProt AC: NX_Q6P1A2
    UniProt: Q6P1A2

  • Chr Location
    12p13.31; chr12:6976185-7018538 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice show low blood glucose levels and postnatal death. Intestine-specific knockouts fail to thrive and show enterocyte lipid accumulation and low plasma triglycerides (TGs). Liver-specific knockouts show low plasma TGs, fatty liver, and secrete VLDL lacking arachidonoyl phospholipids.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004270 Ensembl Gene Model | MGI Sequence Detail 41392 C57BL/6J ±  kb
    transcript ENSMUST00000004381 Ensembl | MGI Sequence Detail 2281 Not Applicable  
    polypeptide ENSMUSP00000004381 Ensembl | MGI Sequence Detail 487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      Genomic 1
      cDNA 117

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
    • Latest
      J:252691 Rong X, et al., ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017 Oct 02;127(10):3640-3651

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory