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M1ap
Gene Detail
Symbol

Name
ID
M1ap
meiosis 1 associated protein
MGI:1315200
Synonyms
D6Mm5e
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:82946902-83030183 bp, + strand
From VEGA annotation of GRCm38

  83282 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: M1ap

Human
homologs
Human Homolog M1AP, meiosis 1 associated protein
NCBI Gene ID 130951
neXtProt AC  NX_Q8TC57
Human Synonyms  C2orf65, D6Mm5e, SPATA37
Human Chr (Location)  2p13.1; chr2:74557883-74648867 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trap allele exhibit male infertility with oligospermia, globozooaspermiam decreased testies weight and size, degeneration of seminiferous tubules, male germ cell apoptosis and arrested male meiosis.
 
Interactions
M1ap interacts with 46 markers (Mir28b, Mir28c, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell differentiation, chromatin assembly, ...
Component cytoplasm, integral component of membrane
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (89)    Tissues (71)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 89
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(9) cDNA(9)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024060 (Evidence)
Ensembl Gene ModelENSMUSG00000030041 (Evidence)
Entrez Gene110958 (Evidence)
UniGene100652
DFCITC1587386, TC1624974
DoTSDT.101371574, DT.101371573, DT.55180617
NIA Mouse Gene IndexU007068
Consensus CDS ProjectCCDS39525.1
International Mouse Knockout Project StatusM1ap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024060 VEGA Gene Model | MGI Sequence Detail 83282 C57BL/6J ±  kb
transcript OTTMUST00000058823 VEGA | MGI Sequence Detail 1945 Not Applicable 
polypeptide OTTMUSP00000028553 VEGA | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(400 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025891 Developmental pluripotency-associated protein 2/4, C-terminal domain
References
(Earliest) J:50420 Weber JS, et al., High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6. Genomics. 1998 Nov 15;54(1):107-15
(Latest) J:194507 Arango NA, et al., Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (m1ap)-deficient mice. Biol Reprod. 2013;88(3):76
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory