Kcnj16 MGI Mouse Gene Detail - MGI:1314842 - potassium inwardly-rectifying channel, subfamily J, member 16

Kcnj16 Gene Detail

Symbol

Kcnj16
Name

potassium inwardly-rectifying channel, subfamily J, member 16
Synonyms

6430410F18Rik, Kir5.1

Feature Type

protein coding gene
IDs

MGI:1314842
NCBI Gene: 16517
Gene Overview

MyGene.info: KCNJ16

Sequence Map

Chr11:110968033-111027968 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

59936 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 75.01 cM
Mapping Data

4 experiments

Human Ortholog

KCNJ16, potassium voltage-gated channel subfamily J member 16

Vertebrate Orthologs

10

Human Ortholog

KCNJ16, potassium voltage-gated channel subfamily J member 16
Orthology source: HomoloGene, HGNC
Synonyms

BIR9, KIR5.1
Links

HGNC:6262

NCBI Gene ID: 3773

neXtProt AC: NX_Q9NPI9
Chr Location

17q24.3; chr17:70075225-70135608 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 23112
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: KCNJ16
Protein SuperFamily

G protein-activated inward rectifier potassium channel
Gene Tree

Kcnj16

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a knock-out allele exhibit abnormal neuron response to ammonium chloride withdrawal and carbon dioxide treatment.

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All GO Annotations

15
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

33
Tissues

27
cDNA Data

51
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase kcnj16

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Kcnj16 interacts with 246 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

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All Sequences

55
RefSeq

10
UniProt

4
CCDS

CCDS25593.1
UniGene

30176

			Length	Strain/Species	Flank
genomic	OTTMUSG00000003322	VEGA Gene Model \| MGI Sequence Detail	59936	C57BL/6J	± kb
transcript	OTTMUST00000006977	VEGA \| MGI Sequence Detail	3623	Not Applicable
polypeptide	OTTMUSP00000003312	VEGA \| MGI Sequence Detail	419	Not Applicable

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SNPs within 2kb

659 from dbSNP Build 142

RFLP

1

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UniProt

4 Sequences
Protein Ontology

PR:000002055 inward rectifier potassium channel 16
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR016449 Potassium channel, inwardly rectifying, Kir

IPR008061 Potassium channel, inwardly rectifying, Kir5

IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic

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All nucleic 52

cDNA 51

Primer pair 1

Microarray probesets 4

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MGI:2144072, MGI:2442290

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 7
Earliest

J:51106 Mouri T, et al., Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Genomics. 1998 Nov 15;54(1):181-2
Latest

J:203001 Zaika OL, et al., Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine. Am J Physiol Renal Physiol. 2013 Nov;305(9):F1277-87

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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