Kcnj16
Gene Detail

Symbol

Name
ID

Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
MGI:1314842

Synonyms

6430410F18Rik, Kir5.1

Feature Type

protein coding gene

Genetic Map

Chromosome 11
75.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:110968033-111027968 bp, + strand From VEGA annotation of GRCm38   59936 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:23112  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj16

Human
homologs

Human Homolog		KCNJ16, potassium inwardly-rectifying channel, subfamily J, member 16
NCBI Gene ID		3773
neXtProt AC		NX_Q9NPI9
Human Synonyms		BIR9, KIR5.1
Human Chr (Location)		17q24.3; chr17:70075207-70135608 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit abnormal neuron response to ammonium chloride withdrawal and carbon dioxide treatment.

 

Interactions

Kcnj16 interacts with 247 markers (Mir1b, Mir7-1, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (15 annotations)

Process	cellular potassium ion transport, ion transport, ...
Component	integral component of membrane, integral component of plasma membrane, ...
Function	inward rectifier potassium channel activity, voltage-gated ion channel activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (33)    Tissues (27)    Images (6)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	30
RT-PCR	3

cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(52) cDNA(51) Primer pair(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000003322 (Evidence)
Ensembl Gene Model	ENSMUSG00000051497 (Evidence)
Entrez Gene	16517 (Evidence)
UniGene	30176
DFCI	TC1747377, TC1744343, TC1594791, TC1579766
DoTS	DT.97404066, DT.94205425, DT.97359927, DT.87068305, DT.60100945, DT.101720052
NIA Mouse Gene Index	U013506
Consensus CDS Project	CCDS25593.1
International Mouse Knockout Project Status	Kcnj16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003322	VEGA Gene Model | MGI Sequence Detail	59936	C57BL/6J
transcript	OTTMUST00000006978	VEGA | MGI Sequence Detail	3671	Not Applicable
polypeptide	OTTMUSP00000003313	VEGA | MGI Sequence Detail	419	Not Applicable

All sequences(69) RefSeq(10) UniProt(7)

Polymorphisms

RFLP(1) : SNPs within 2kb(660 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR008061	Potassium channel, inwardly rectifying, Kir5
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology	PR:000002055	inward rectifier potassium channel 16

References

(Earliest) J:51106 Mouri T, et al., Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Genomics. 1998 Nov 15;54(1):181-2
(Latest) J:203001 Zaika OL, et al., Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine. Am J Physiol Renal Physiol. 2013 Nov;305(9):F1277-87
All references(45)

Other
accession IDs

MGI:2144072, MGI:2442290