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Kcnj16 Gene Detail
Summary
  • Symbol
    Kcnj16
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 16
  • Synonyms
    6430410F18Rik, Kir5.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314842
    NCBI Gene: 16517
  • Gene Overview
    MyGene.info: KCNJ16
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:110968033-111027968 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 75.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    659 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314842
protein coding gene Chr11:110968033-111027968 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019346
protein coding gene Chr11:114636042-114696798 (+)
A/J MGP_AJ_G0019314
protein coding gene Chr11:109671235-109733938 (+)
AKR/J MGP_AKRJ_G0019283
protein coding gene Chr11:112934398-112996956 (+)
BALB/cJ MGP_BALBcJ_G0019288
protein coding gene Chr11:110102576-110165127 (+)
C3H/HeJ MGP_C3HHeJ_G0019097
protein coding gene Chr11:113260434-113323227 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019738
protein coding gene Chr11:118085211-118154829 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017361
protein coding gene Chr11:106837702-106897435 (+)
CAST/EiJ MGP_CASTEiJ_G0018650
protein coding gene Chr11:114439729-114506572 (+)
CBA/J MGP_CBAJ_G0019066
protein coding gene Chr11:122917547-122983779 (+)
DBA/2J MGP_DBA2J_G0019178
protein coding gene Chr11:109141079-109202461 (+)
FVB/NJ MGP_FVBNJ_G0019169
protein coding gene Chr11:108588132-108647444 (+)
LP/J MGP_LPJ_G0019248
protein coding gene Chr11:115043091-115107491 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019200
protein coding gene Chr11:122074387-122137718 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019775
protein coding gene Chr11:113535307-113599644 (+)
PWK/PhJ MGP_PWKPhJ_G0018415
protein coding gene Chr11:110309694-110382275 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018207
protein coding gene Chr11:113346058-113411881 (+)
WSB/EiJ MGP_WSBEiJ_G0018702
protein coding gene Chr11:113470602-113533539 (+)



Homology
more
  • Human Ortholog
    KCNJ16, potassium voltage-gated channel subfamily J member 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ16, potassium voltage-gated channel subfamily J member 16
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BIR9, KIR5.1
  • Links
    NCBI Gene ID: 3773
    neXtProt AC: NX_Q9NPI9
    UniProt: Q9NPI9

  • Chr Location
    17q24.3; chr17:70075225-70135608 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal neuron response to ammonium chloride withdrawal and carbon dioxide treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16517 NCBI Gene Model | MGI Sequence Detail 59936 C57BL/6J ±  kb
transcript NM_001252207 RefSeq | MGI Sequence Detail 3718 C57BL/6  
polypeptide Q9Z307 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR008061 Potassium channel, inwardly rectifying, Kir5
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 53
    cDNA 52
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144072, MGI:2442290
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:51106 Mouri T, et al., Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Genomics. 1998 Nov 15;54(1):181-2
  • Latest
    J:235642 Franke M, et al., Formation of new chromatin domains determines pathogenicity of genomic duplications. Nature. 2016 Oct 13;538(7624):265-269

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory