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Kcnj16 Gene Detail
Summary
  • Symbol
    Kcnj16
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 16
  • Synonyms
    6430410F18Rik, Kir5.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314842
    NCBI Gene: 16517
  • Gene Overview
    MyGene.info: KCNJ16
Location & Maps
more
  • Sequence Map
    Chr11:110968033-111027968 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59936 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KCNJ16, potassium voltage-gated channel subfamily J member 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ16, potassium voltage-gated channel subfamily J member 16
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BIR9, KIR5.1
  • Links
    NCBI Gene ID: 3773
    neXtProt AC: NX_Q9NPI9

  • Chr Location
    17q24.3; chr17:70075225-70135608 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal neuron response to ammonium chloride withdrawal and carbon dioxide treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003322 VEGA Gene Model | MGI Sequence Detail 59936 C57BL/6J ±  kb
transcript OTTMUST00000006977 VEGA | MGI Sequence Detail 3623 Not Applicable  
polypeptide OTTMUSP00000003312 VEGA | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    659 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002055 inward rectifier potassium channel 16
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR008061 Potassium channel, inwardly rectifying, Kir5
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 52
    cDNA 51
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2144072, MGI:2442290
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:51106 Mouri T, et al., Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Genomics. 1998 Nov 15;54(1):181-2
  • Latest
    J:203001 Zaika OL, et al., Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine. Am J Physiol Renal Physiol. 2013 Nov;305(9):F1277-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory