Kcnj16 MGI Mouse Gene Detail - MGI:1314842 - potassium inwardly-rectifying channel, subfamily J, member 16

Symbol

Kcnj16
Name

potassium inwardly-rectifying channel, subfamily J, member 16
Synonyms

6430410F18Rik, Kir5.1

Feature Type

protein coding gene
IDs

MGI:1314842
NCBI Gene: 16517
Gene Overview

MyGene.info: KCNJ16
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:110968033-111027968 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 75.01 cM
Mapping Data

4 experiments

SNPs within 2kb

659 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1314842	protein coding gene	Chr11:110968033-111027968 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019346	protein coding gene	Chr11:114636042-114696798 (+)
A/J	MGP_AJ_G0019314	protein coding gene	Chr11:109671235-109733938 (+)
AKR/J	MGP_AKRJ_G0019283	protein coding gene	Chr11:112934398-112996956 (+)
BALB/cJ	MGP_BALBcJ_G0019288	protein coding gene	Chr11:110102576-110165127 (+)
C3H/HeJ	MGP_C3HHeJ_G0019097	protein coding gene	Chr11:113260434-113323227 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019738	protein coding gene	Chr11:118085211-118154829 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017361	protein coding gene	Chr11:106837702-106897435 (+)
CAST/EiJ	MGP_CASTEiJ_G0018650	protein coding gene	Chr11:114439729-114506572 (+)
CBA/J	MGP_CBAJ_G0019066	protein coding gene	Chr11:122917547-122983779 (+)
DBA/2J	MGP_DBA2J_G0019178	protein coding gene	Chr11:109141079-109202461 (+)
FVB/NJ	MGP_FVBNJ_G0019169	protein coding gene	Chr11:108588132-108647444 (+)
LP/J	MGP_LPJ_G0019248	protein coding gene	Chr11:115043091-115107491 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019200	protein coding gene	Chr11:122074387-122137718 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019775	protein coding gene	Chr11:113535307-113599644 (+)
PWK/PhJ	MGP_PWKPhJ_G0018415	protein coding gene	Chr11:110309694-110382275 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018207	protein coding gene	Chr11:113346058-113411881 (+)
WSB/EiJ	MGP_WSBEiJ_G0018702	protein coding gene	Chr11:113470602-113533539 (+)

Human Ortholog

KCNJ16, potassium inwardly rectifying channel subfamily J member 16

Vertebrate Orthologs

10

Human Ortholog

KCNJ16, potassium inwardly rectifying channel subfamily J member 16
Orthology source: HomoloGene, HGNC
Synonyms

BIR9, KIR5.1
Links

HGNC:6262

NCBI Gene ID: 3773

neXtProt AC: NX_Q9NPI9

UniProt: Q9NPI9
Chr Location

17q24.3; chr17:70075225-70135608 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 23112
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KCNJ16
Protein SuperFamily

G protein-activated inward rectifier potassium channel
Gene Tree

Kcnj16

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

3 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal neuron response to ammonium chloride withdrawal and carbon dioxide treatment.

less

All GO Annotations

17
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

664
Tissues

27
cDNA Data

52
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnj16

less

Kcnj16 interacts with 246 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

less

All Sequences

66
RefSeq

12
UniProt

4
CCDS

CCDS25593.1
UniGene

30176

Ensembl

ENSMUSG00000051497 (Evidence)
NCBI Gene

16517

			Length	Strain/Species	Flank
genomic	16517	NCBI Gene Model \| MGI Sequence Detail	59936	C57BL/6J	± kb
transcript	NM_001252207	RefSeq \| MGI Sequence Detail	3718	C57BL/6
polypeptide	Q9Z307	UniProt \| EBI \| MGI Sequence Detail	419	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000002055 inward rectifier potassium channel 16

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR041647 Inward rectifier potassium channel, C-terminal

IPR016449 Potassium channel, inwardly rectifying, Kir

IPR008061 Potassium channel, inwardly rectifying, Kir5

IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic

IPR040445 Potassium channel, inwardly rectifying, transmembrane domain

less

All nucleic 53

cDNA 52

Primer pair 1

Microarray probesets 4

less

MGI:2144072, MGI:2442290

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 8
Earliest

J:51106 Mouri T, et al., Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Genomics. 1998 Nov 15;54(1):181-2
Latest

J:294659 Wu P, et al., Deletion of Kir5.1 Impairs Renal Ability to Excrete Potassium during Increased Dietary Potassium Intake. J Am Soc Nephrol. 2019 Aug;30(8):1425-1438

TSS for Kcnj16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105718	Chr11:110968016-110968042 (+)	-4 bp
Tssr105719	Chr11:110968056-110968070 (+)	30 bp
Tssr105721	Chr11:110997054-110997062 (+)	29,025 bp
Tssr105722	Chr11:110997085-110997097 (+)	29,058 bp
Tssr105723	Chr11:110997493-110997504 (+)	29,466 bp
Tssr105724	Chr11:110997509-110997542 (+)	29,493 bp
Tssr105725	Chr11:110997544-110997552 (+)	29,515 bp
Tssr105726	Chr11:111023853-111023871 (+)	55,829 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/19/2021 MGI 6.16