Vamp2
Gene Detail

Symbol Name ID

Vamp2 vesicle-associated membrane protein 2 MGI:1313277

Synonyms

Syb2, Syb-2, sybII, synaptobrevin II

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.36 cM
Detailed Genetic Map ± 1 cM

Sequence Map

Chr11:69088490-69092384 bp, + strand From VEGA annotation of GRCm38   3895 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7591  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: synaptobrevin
Gene Tree: Vamp2

Human homologs

Human Homolog		VAMP2, vesicle-associated membrane protein 2 (synaptobrevin 2)
NCBI Gene ID		6844
neXtProt AC		NX_P63027
Human Synonyms		SYB2, VAMP-2
Human Chr (Location)		17p13.1; chr17:8062465-8066293 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygous null mutants show 10X reduction in synaptic vesicle fusion and hypertonic sucrose-induced fusion and >100X reduction in fusion triggered by fast Ca2+. Newborn pups are rounded in appearance, with humped shoulders, and die immediately.

 

Gene Ontology (GO) classifications

All GO classifications: (57 annotations)

Process	calcium ion-dependent exocytosis, cellular membrane fusion, ...
Component	cell junction, clathrin-coated vesicle, ...
Function	calmodulin binding, myosin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (167)    Tissues (131)    Images (27)
Theiler Stages: 19, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	136
Western blot	23

cDNA source data(132)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(133) cDNA(132) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005972 (Evidence)
Ensembl Gene Model	ENSMUSG00000020894 (Evidence)
Entrez Gene	22318 (Evidence)
UniGene	28643
DFCI	TC1572417
DoTS	DT.110503833, DT.532905
NIA Mouse Gene Index	U012809
Consensus CDS Project	CCDS24881.1
International Mouse Knockout Project Status	Vamp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005972	VEGA Gene Model | MGI Sequence Detail	3895	C57BL/6J
transcript	OTTMUST00000013341	VEGA | MGI Sequence Detail	1113	Not Applicable
polypeptide	OTTMUSP00000035737	VEGA | MGI Sequence Detail	163	Not Applicable

All sequences(34) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001388	Synaptobrevin
InterPro	IPR016444	Synaptobrevin, metazoa/fungi
Protein Ontology	PR:000017249	vesicle-associated membrane protein 2

References

(Earliest) J:10766 Archer BT 3rd, et al., Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73
(Latest) J:192579 Fang Q, et al., Juxtamembrane tryptophans of synaptobrevin 2 control the process of membrane fusion. FEBS Lett. 2013 Jan 4;587(1):67-72
All references(97)

Other accession IDs

MGD-MRK-14676, MGD-MRK-14678, MGI:98459