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Vamp2
Gene Detail
 Symbol
Name
ID
Vamp2
vesicle-associated membrane protein 2
MGI:1313277
Synonyms Syb2, Syb-2, sybII, synaptobrevin II
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.36 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr11:69088490-69092384 bp, + strand
From VEGA annotation of GRCm38

  3895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7591  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: synaptobrevin
Gene Tree: Vamp2

Human
homologs
Human Homolog VAMP2, vesicle-associated membrane protein 2 (synaptobrevin 2)
NCBI Gene ID 6844
neXtProt AC  NX_P63027
Human Synonyms  SYB2, VAMP-2
Human Chr (Location)  17p13.1; chr17:8159147-8162975 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants show 10X reduction in synaptic vesicle fusion and hypertonic sucrose-induced fusion and >100X reduction in fusion triggered by fast Ca2+. Newborn pups are rounded in appearance, with humped shoulders, and die immediately.
 
Interactions
Vamp2 interacts with 302 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process calcium ion-dependent exocytosis, cellular response to insulin stimulus, ...
Component cell, cell junction, ...
Function calmodulin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (219)    Tissues (183)    Images (33)
Theiler Stages: 19, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 185
Western blot 23
cDNA source data(134)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(135) cDNA(134) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005972 (Evidence)
Ensembl Gene ModelENSMUSG00000020894 (Evidence)
Entrez Gene22318 (Evidence)
UniGene28643
DFCITC1572417
DoTSDT.110503833, DT.532905
NIA Mouse Gene IndexU012809
Consensus CDS ProjectCCDS24881.1
International Mouse Knockout Project StatusVamp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005972 VEGA Gene Model | MGI Sequence Detail 3895 C57BL/6J ±  kb
transcript OTTMUST00000013341 VEGA | MGI Sequence Detail 1113 Not Applicable 
polypeptide OTTMUSP00000035737 VEGA | MGI Sequence Detail 163 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001388 Synaptobrevin
InterPro IPR016444 Synaptobrevin, metazoa/fungi
Protein Ontology PR:000017249 vesicle-associated membrane protein 2
References (Earliest) J:10766 Archer BT 3rd, et al., Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73
(Latest) J:207214 Zhou P, et al., Lipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter release. Neuron. 2013 Oct 16;80(2):470-83
All references(108)
Other
accession IDs
MGD-MRK-14676, MGD-MRK-14678, MGI:98459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory