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Ugdh Gene Detail
Summary
  • Symbol
    Ugdh
  • Name
    UDP-glucose dehydrogenase
  • Synonyms
    Udpgdh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306785
    NCBI Gene: 22235
  • Gene Overview
    MyGene.info: UGDH
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65413207-65435842 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 33.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306785
protein coding gene Chr5:65413207-65435949 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029578
protein coding gene Chr5:65047790-65073112 (-)
A/J MGP_AJ_G0029546
protein coding gene Chr5:62632868-62656650 (-)
AKR/J MGP_AKRJ_G0029494
protein coding gene Chr5:64625039-64649880 (-)
BALB/cJ MGP_BALBcJ_G0029555
protein coding gene Chr5:63323248-63346424 (-)
C3H/HeJ MGP_C3HHeJ_G0029278
protein coding gene Chr5:64964030-64988385 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030009
protein coding gene Chr5:67728600-67753634 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027249
protein coding gene Chr5:58706940-58728989 (-)
CAST/EiJ MGP_CASTEiJ_G0028686
protein coding gene Chr5:64067481-64089959 (-)
CBA/J MGP_CBAJ_G0029247
protein coding gene Chr5:69928459-69955151 (-)
DBA/2J MGP_DBA2J_G0029393
protein coding gene Chr5:62671364-62693815 (-)
FVB/NJ MGP_FVBNJ_G0029353
protein coding gene Chr5:61843196-61866139 (-)
LP/J MGP_LPJ_G0029478
protein coding gene Chr5:65555418-65580653 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029381
protein coding gene Chr5:72811144-72834381 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030042
protein coding gene Chr5:64295961-64318960 (-)
PWK/PhJ MGP_PWKPhJ_G0028410
protein coding gene Chr5:61635613-61658540 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028244
protein coding gene Chr5:63612227-63634450 (-)
WSB/EiJ MGP_WSBEiJ_G0028766
protein coding gene Chr5:64498703-64521184 (-)



Homology
more
  • Human Ortholog
    UGDH, UDP-glucose 6-dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UGDH, UDP-glucose 6-dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GDH, UDPGDH, UDP-GlcDH, UGD
  • Links
    NCBI Gene ID: 7358
    neXtProt AC: NX_O60701
    UniProt: O60701

  • Chr Location
    4p14; chr4:39498755-39527598 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutation of this gene results in developmental arrest during gastrulation with defects in endoderm and mesoderm migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22235 NCBI Gene Model | MGI Sequence Detail 22636 C57BL/6J ±  kb
    transcript NM_009466 RefSeq | MGI Sequence Detail 2461 FVB/N  
    polypeptide O70475 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017046 UDP-glucose 6-dehydrogenase
    • EC
    • InterPro Domains
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR036291 NAD(P)-binding domain superfamily
      IPR028356 UDP-glucose 6-dehydrogenase, eukaryotic type
      IPR017476 UDP-glucose/GDP-mannose dehydrogenase
      IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
      IPR036220 UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily
      IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
      IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 108
      Genomic 1
      cDNA 106
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:240973 Tao C, et al., Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis. Cell Rep. 2016 Nov 08;17(7):1832-1844

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory