About   Help   FAQ
Ugdh Gene Detail
Summary
  • Symbol
    Ugdh
  • Name
    UDP-glucose dehydrogenase
  • Synonyms
    Udpgdh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306785
    NCBI Gene: 22235
  • Gene Overview
    MyGene.info: UGDH
Location & Maps
more
  • Sequence Map
    Chr5:65413221-65435949 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22729 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 33.67 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    UGDH, UDP-glucose 6-dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UGDH, UDP-glucose 6-dehydrogenase
    Orthology source: HomoloGene
  • Synonyms
    GDH, UDPGDH, UDP-GlcDH, UGD
  • Links
    NCBI Gene ID: 7358
    neXtProt AC: NX_O60701

  • Chr Location
    4p15.1; chr4:39498755-39527598 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    15
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Ugdh
  • Incidental Mutations
    APF
Mutation of this gene results in developmental arrest during gastrulation with defects in endoderm and mesoderm migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028398 VEGA Gene Model | MGI Sequence Detail 22729 C57BL/6J ±  kb
transcript OTTMUST00000070363 VEGA | MGI Sequence Detail 2550 Not Applicable  
polypeptide OTTMUSP00000035847 VEGA | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    110 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017046 UDP-glucose 6-dehydrogenase
  • EC
  • InterPro Domains
    IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like
    IPR016040 NAD(P)-binding domain
    IPR028356 UDP-glucose 6-dehydrogenase, eukaryotic type
    IPR017476 UDP-glucose/GDP-mannose dehydrogenase
    IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
    IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
    IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
Molecular
Reagents
less
  • All nucleic 107
    Genomic 1
    cDNA 105
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 23
  • Earliest
    J:50095 Spicer AP, et al., Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes. J Biol Chem. 1998 Sep 25;273(39):25117-24
  • Latest
    J:190407 Hyde AS, et al., UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly. J Biol Chem. 2012 Sep 21;287(39):32708-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory