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Ugdh
Gene Detail
Symbol

Name
ID
Ugdh
UDP-glucose dehydrogenase
MGI:1306785
Synonyms
Udpgdh
Feature Type
protein coding gene
Genetic Map
Chromosome 5
33.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:65413221-65435949 bp, - strand
From VEGA annotation of GRCm38

  22729 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2520  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UGDH
Protein SuperFamily: UDP-glucose/GDP-mannose dehydrogenase
Gene Tree: Ugdh

Human
homologs
UGDH, UDP-glucose 6-dehydrogenase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7358
neXtProt AC: NX_O60701

Human Synonyms: GDH, UDPGDH, UDP-GlcDH, UGD

Human Chr (Location): 4p15.1; chr4:39498755-39527598 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(1) Gene trapped(15) Radiation induced(1) Targeted(3)
Genomic Mutations involving Ugdh (1)
Incidental mutations (data from APF )
 
Mutation of this gene results in developmental arrest during gastrulation with defects in endoderm and mesoderm migration.
 
Phenotype Images(4)
Interactions
Ugdh interacts with 121 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process gastrulation with mouth forming second, metabolic process, ...
Component cytosol, extracellular exosome, ...
Function catalytic activity, NAD binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (98)    Tissues (98)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 4
cDNA source data(104)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ugdh, ugdh.2 ; ZFIN ugdh    NEW 
Molecular
reagents
All nucleic(107) Genomic(1) cDNA(105) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028398 (Evidence)
Ensembl Gene Model ENSMUSG00000029201 (Evidence)
Entrez Gene 22235 (Evidence)
UniGene 344831
DFCI TC1572553, TC1612994
DoTS DT.532354, DT.91383671, DT.94310147
NIA Mouse Gene Index U026243
EC 1.1.1.22
Consensus CDS Project CCDS19308.1
International Mouse Phenotyping Consortium Status Ugdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028398 VEGA Gene Model | MGI Sequence Detail 22729 C57BL/6J ±  kb
transcript OTTMUST00000070363 VEGA | MGI Sequence Detail 2550 Not Applicable 
polypeptide OTTMUSP00000035847 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR028357 UDP-glucose 6-dehydrogenase, bacterial type
InterPro IPR028356 UDP-glucose 6-dehydrogenase, eukaryotic type
InterPro IPR017476 UDP-glucose/GDP-mannose dehydrogenase
InterPro IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
InterPro IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
InterPro IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
Protein Ontology PR:000017046 UDP-glucose 6-dehydrogenase
References
(Earliest) J:50095 Spicer AP, et al., Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes. J Biol Chem. 1998 Sep 25;273(39):25117-24
(Latest) J:190407 Hyde AS, et al., UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly. J Biol Chem. 2012 Sep 21;287(39):32708-16
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory