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Ugdh
Gene Detail
 Symbol
Name
ID
Ugdh
UDP-glucose dehydrogenase
MGI:1306785
Synonyms Udpgdh
Feature Type protein coding gene
Genetic Map
Chromosome 5
33.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:65413202-65435946 bp, - strand
From VEGA annotation of GRCm38

  22745 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2520  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: UDP-glucose/GDP-mannose dehydrogenase
Gene Tree: Ugdh

Human
homologs
Human Homolog UGDH, UDP-glucose 6-dehydrogenase
NCBI Gene ID 7358
neXtProt AC  NX_O60701
Human Synonyms  GDH, UDPGDH, UDP-GlcDH, UGD
Human Chr (Location)  4p15.1; chr4:39498755-39527900 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Chemically induced (ENU)(1) Gene trapped(22) Targeted(3)
Incidental mutations (data from APF )
 
Mutation of this gene results in developmental arrest during gastrulation with defects in endoderm and mesoderm migration.
 
Interactions
Ugdh interacts with 121 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process gastrulation with mouth forming second, metabolic process, ...
Component cytosol, nucleus
Function catalytic activity, NAD binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (98)    Tissues (98)    Images (14)
Theiler Stages: 11, 19, 22, 23, 25
Assay TypeResults
RNA in situ 94
Northern blot 4
cDNA source data(104)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(107) Genomic(1) cDNA(105) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028398 (Evidence)
Ensembl Gene ModelENSMUSG00000029201 (Evidence)
Entrez Gene22235 (Evidence)
UniGene344831
DFCITC1572553, TC1612994
DoTSDT.532354, DT.91383671, DT.94310147
NIA Mouse Gene IndexU026243
EC1.1.1.22
Consensus CDS ProjectCCDS19308.1
International Mouse Knockout Project StatusUgdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028398 VEGA Gene Model | MGI Sequence Detail 22745 C57BL/6J ±  kb
transcript OTTMUST00000070363 VEGA | MGI Sequence Detail 2547 Not Applicable 
polypeptide OTTMUSP00000035847 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR017476 Nucleotide sugar dehydrogenase
InterPro IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
InterPro IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
InterPro IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
Protein Ontology PR:000017046 UDP-glucose 6-dehydrogenase
References (Earliest) J:50095 Spicer AP, et al., Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes. J Biol Chem. 1998 Sep 25;273(39):25117-24
(Latest) J:190407 Hyde AS, et al., UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly. J Biol Chem. 2012 Sep 21;287(39):32708-16
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory