Ccl22
Gene Detail

Symbol Name ID

Ccl22 chemokine (C-C motif) ligand 22 MGI:1306779

Synonyms

ABCD-1, MDC, Scya22

Feature Type

protein coding gene

Genetic Map

Chromosome 8

46.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:94745590-94751699 bp, + strand From VEGA annotation of GRCm38   6110 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl22

Human homologs

Human Homolog		CCL22, chemokine (C-C motif) ligand 22
NCBI Gene ID		6367
neXtProt AC		NX_O00626
Human Synonyms		ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1
Human Chr (Location)		16q13; chr16:57392695-57400102 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	chemotaxis, immune response, ...
Component	extracellular region, extracellular space
Function	chemokine activity, cytokine activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (5)   
Theiler Stages: 21, 23, 25, 28

Assay Type	Results
RT-PCR	11

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(1) cDNA(26) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016635 (Evidence)
Ensembl Gene Model	ENSMUSG00000031779 (Evidence)
Entrez Gene	20299 (Evidence)
UniGene	12895
DFCI	TC1578765
DoTS	DT.489927
NIA Mouse Gene Index	U009672
Consensus CDS Project	CCDS40441.1
International Mouse Knockout Project Status	Ccl22

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016635	VEGA Gene Model | MGI Sequence Detail	6110	C57BL/6J
transcript	OTTMUST00000040245	VEGA | MGI Sequence Detail	2216	Not Applicable
polypeptide	OTTMUSP00000017971	VEGA | MGI Sequence Detail	92	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000827	CC chemokine, conserved site
InterPro	IPR001811	Chemokine interleukin-8-like domain
InterPro	IPR002473	CXC chemokine, interleukin 8
Protein Ontology	PR:000001994	C-C motif chemokine 22

References

(Earliest) J:49499 Schaniel C, et al., Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J Exp Med. 1998 Aug 3;188(3):451-63
(Latest) J:176172 Montane J, et al., Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J Clin Invest. 2011 Aug 1;121(8):3024-8
All references(38)