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Umps
Gene Detail
Symbol

Name
ID
Umps
uridine monophosphate synthetase
MGI:1298388
Synonyms
1700095D23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
24.26 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:33954782-33967038 bp, - strand
From VEGA annotation of GRCm38

  12257 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:319  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UMPS
Protein SuperFamily: UMP synthase
Gene Tree: Umps

Human
homologs
UMPS, uridine monophosphate synthetase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7372
neXtProt AC: NX_P11172

Human Synonyms: OPRT

Human Chr (Location): 3q13; chr3:124730366-124749273 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human UMPS

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Umps interacts with 298 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (106)    Tissues (102)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase umps ; ZFIN umps    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000031003 (Evidence)
Ensembl Gene Model ENSMUSG00000022814 (Evidence)
Entrez Gene 22247 (Evidence)
DFCI TC1635505, TC1600828, TC1575256
DoTS DT.101213483, DT.55241757, DT.531271, DT.94343390
NIA Mouse Gene Index U041191
EC 2.4.2.10, 4.1.1.23
Consensus CDS Project CCDS28136.1
International Mouse Phenotyping Consortium Status Umps
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031003 VEGA Gene Model | MGI Sequence Detail 12257 C57BL/6J ±  kb
transcript OTTMUST00000065699 VEGA | MGI Sequence Detail 3484 Not Applicable 
polypeptide OTTMUSP00000032775 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR023031 Orotate phosphoribosyltransferase
InterPro IPR004467 Orotate phosphoribosyl transferase domain
InterPro IPR014732 Orotidine 5'-phosphate decarboxylase
InterPro IPR018089 Orotidine 5'-phosphate decarboxylase, active site
InterPro IPR001754 Orotidine 5'-phosphate decarboxylase domain
InterPro IPR000836 Phosphoribosyltransferase domain
InterPro IPR011060 Ribulose-phosphate binding barrel
Protein Ontology PR:000017083 uridine 5'-monophosphate synthase
References
(Earliest) J:49359 Ohmstede CA, et al., Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase. J Biol Chem. 1986 Mar 25;261(9):4276-82
(Latest) J:187427 Rainger J, et al., Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. Hum Mol Genet. 2012 Sep 15;21(18):3969-83
All references(35)
Other
accession IDs
MGI:1920822, MGI:2146334, MGI:2146531, MGI:2146687

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory