Umps
Gene Detail

Symbol Name ID

Umps uridine monophosphate synthetase MGI:1298388

Synonyms

1700095D23Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 16

24.26 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:33954782-33967038 bp, - strand From VEGA annotation of GRCm38   12257 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:319  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: UMP synthase
Gene Tree: Umps

Human homologs

Human Homolog		UMPS, uridine monophosphate synthetase
NCBI Gene ID		7372
neXtProt AC		NX_P11172
Human Synonyms		OPRT
Human Chr (Location)		3q13; chr3:124449213-124468120 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human UMPS

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(4)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	'de novo' pyrimidine nucleobase biosynthetic process, 'de novo' UMP biosynthetic process, ...
Component	cytoplasm, nucleus
Function	carboxy-lyase activity, catalytic activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (106)    Tissues (102)    Images (1)
Theiler Stages: 17, 22

Assay Type	Results
RNA in situ	106

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000031003 (Evidence)
Ensembl Gene Model	ENSMUSG00000022814 (Evidence)
Entrez Gene	22247 (Evidence)
DFCI	TC1575256, TC1600828, TC1635505
DoTS	DT.101213483, DT.531271, DT.55241757, DT.94343390
NIA Mouse Gene Index	U041191
EC	2.4.2.10, 4.1.1.23
Consensus CDS Project	CCDS28136.1
International Mouse Knockout Project Status	Umps

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031003	VEGA Gene Model | MGI Sequence Detail	12257	C57BL/6J
transcript	OTTMUST00000065699	VEGA | MGI Sequence Detail	3484	Not Applicable
polypeptide	OTTMUSP00000032775	VEGA | MGI Sequence Detail	481	Not Applicable

All sequences(47) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(98 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR023031	Orotate phosphoribosyltransferase
InterPro	IPR004467	Orotate phosphoribosyl transferase domain
InterPro	IPR014732	Orotidine 5'-phosphate decarboxylase
InterPro	IPR018089	Orotidine 5'-phosphate decarboxylase, active site
InterPro	IPR001754	Orotidine 5'-phosphate decarboxylase domain
InterPro	IPR000836	Phosphoribosyltransferase domain
InterPro	IPR011060	Ribulose-phosphate binding barrel
Protein Ontology	PR:000017083	uridine 5'-monophosphate synthase

References

(Earliest) J:49359 Ohmstede CA, et al., Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase. J Biol Chem. 1986 Mar 25;261(9):4276-82
(Latest) J:187427 Rainger J, et al., Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. Hum Mol Genet. 2012 Sep 15;21(18):3969-83
All references(37)

Other accession IDs

MGI:1920822, MGI:2146334, MGI:2146531, MGI:2146687