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Naip2 Gene Detail
Summary
  • Symbol
    Naip2
  • Name
    NLR family, apoptosis inhibitory protein 2
  • Synonyms
    Birc1b, Naip2, Naip-rs6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298226
    NCBI Gene: 17948
  • Member of
    Naipc cluster
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100280571-100338600 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 53.01 cM, cytoband D1-D3
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298226
 protein coding gene Chr13:100280571-100338630 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020882
 protein coding gene Chr13:101977511-102051046 (-)
A/J MGP_AJ_G0020836
 protein coding gene Chr13:98047904-98108133 (-)
AKR/J MGP_AKRJ_G0020810
 protein coding gene Chr13:101043040-101108282 (-)
BALB/cJ MGP_BALBcJ_G0020834
 protein coding gene Chr13:98764496-98834292 (-)
C3H/HeJ MGP_C3HHeJ_G0020625
 protein coding gene Chr13:100766334-100828710 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021268
 protein coding gene Chr13:105003804-105090556 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018837
 protein coding gene Chr13:93762563-93820903 (-)
CAST/EiJ MGP_CASTEiJ_G0020143
 protein coding gene Chr13:100207091-100266067 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0020710
 protein coding gene Chr13:97810713-97873996 (-)
FVB/NJ MGP_FVBNJ_G0020691
 protein coding gene Chr13:96558212-96622776 (-)
LP/J MGP_LPJ_G0020785
 protein coding gene Chr13:102058246-102122289 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020719
 protein coding gene Chr13:109421811-109504302 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021309
 protein coding gene Chr13:100514200-100583547 (-)
PWK/PhJ MGP_PWKPhJ_G0019896
 protein coding gene Chr13:96641028-96707293 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019719
 protein coding gene Chr13:96786318-96800219 (-)
WSB/EiJ MGP_WSBEiJ_G0020201
 protein coding gene Chr13:100929482-101003631 (-)



Homology
more
  • Human Ortholog
    NAIP, NLR family apoptosis inhibitory protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAIP, NLR family apoptosis inhibitory protein
  • Synonyms
    BIRC1, NLRB1, psiNAIP
  • Links
    NCBI Gene ID: 4671
    neXtProt AC: NX_Q13075
    UniProt: Q13075

  • Chr Location
    5q13.2; chr5:70968166-71025339 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    45
  • cDNA Data
    11
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078945 Ensembl Gene Model | MGI Sequence Detail 58030 C57BL/6J ±  kb
transcript ENSMUST00000117913 Ensembl | MGI Sequence Detail 4823 Not Applicable  
polypeptide ENSMUSP00000113890 Ensembl | MGI Sequence Detail 1447 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 15
    cDNA 11
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-38479, MGI:109434
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:37707 Scharf JM, et al., The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5. Genomics. 1996 Dec 15;38(3):405-17
  • Latest
    J:233320 Rauch I, et al., NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. J Exp Med. 2016 May 2;213(5):657-65
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory