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Naip2
Gene Detail
 Symbol
Name
ID
Naip2
NLR family, apoptosis inhibitory protein 2
MGI:1298226
Synonyms Birc1b, Naip2, Naip-rs6
Feature Type protein coding gene
Genetic Map
Chromosome 13
53.01 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr13:100144063-100202092 bp, - strand
From VEGA annotation of GRCm38

  58030 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136092  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog

Protein SuperFamily: neuronal apoptosis inhibitory protein
Gene Tree: Naip2

Human
homologs
Human Homolog NAIP, NLR family, apoptosis inhibitory protein
NCBI Gene ID 4671
neXtProt AC  NX_Q13075
Human Synonyms  BIRC1, NLRB1, psiNAIP
Human Chr (Location)  5q13.2; chr5:70968483-71025114 (-)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Naip2 interacts with 67 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apoptotic process, cellular response to estrogen stimulus, ...
Component extracellular vesicular exosome, IPAF inflammasome complex
Function ATP binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (48)    Tissues (45)    Images (3)
Theiler Stages: 17, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 38
RT-PCR 10
cDNA source data(11)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(15) cDNA(11) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000028711 (Evidence)
Ensembl Gene ModelENSMUSG00000078945 (Evidence)
Entrez Gene17948 (Evidence)
UniGene89961
DFCITC1585714, TC1686597
DoTSDT.87051347, DT.99846715
NIA Mouse Gene IndexU303051
Consensus CDS ProjectCCDS26726.1
International Mouse Knockout Project StatusNaip2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028711 VEGA Gene Model | MGI Sequence Detail 58030 C57BL/6J ±  kb
transcript OTTMUST00000071109 VEGA | MGI Sequence Detail 4823 Not Applicable 
polypeptide OTTMUSP00000036366 VEGA | MGI Sequence Detail 1447 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(10)
Polymorphisms PCR(2) : SNPs within 2kb(303 from dbSNP Build 137)    SNPs within 2kb including multiple locations(335)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011553 baculoviral IAP repeat-containing protein 1b
References (Earliest) J:37707 Scharf JM, et al., The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5. Genomics. 1996 Dec 15;38(3):405-17
(Latest) J:176197 Kofoed EM, et al., Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature. 2011 Sep 29;477(7366):592-5
All references(35)
Other
accession IDs
MGD-MRK-38479, MGI:109434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory