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Arhgef25
Gene Detail
 Symbol
Name
ID
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
MGI:1277173
Synonyms 2410008H17Rik, D10Ertd610e, GEFT
Feature Type protein coding gene
Genetic Map
Chromosome 10
74.50 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:127182521-127190054 bp, - strand
From NCBI annotation of GRCm38

  7534 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: RhoA guanine nucleotide exchange factor p63RhoAGef
Gene Tree: Arhgef25

Human
homologs
Human Homolog ARHGEF25, Rho guanine nucleotide exchange factor (GEF) 25
NCBI Gene ID 115557
neXtProt AC  NX_Q86VW2
Human Synonyms  GEFT, p63RhoGEF
Human Chr (Location)  12q13.3; chr12:57610180-57617245 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Targeted(1) Gene trapped(8)
 
Mice homozygous for a conditional allele activated in the second heart field exhibit normal cardiac development and prenatal survival.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process regulation of Rho protein signal transduction
Component cytoplasm, membrane, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (69)    Tissues (49)    Images (21)
Theiler Stages: 17, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 59
Northern blot 6
RT-PCR 4
cDNA source data(72)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(75) cDNA(72) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000019467 (Evidence)
Entrez Gene52666 (Evidence)
UniGene272230
DFCITC1577945, TC1589942, TC1662916, TC1739643
DoTSDT.101153105, DT.101331656, DT.101379341, DT.102534309, DT.531319, DT.97353967
NIA Mouse Gene IndexU032327
Consensus CDS ProjectCCDS24231.1, CCDS48715.1
International Mouse Knockout Project StatusArhgef25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 52666 NCBI Gene Model | MGI Sequence Detail 7534 C57BL/6J ±  kb
transcript NM_028027 RefSeq | MGI Sequence Detail 2261 C57BL/6 
polypeptide Q9CWR0 UniProt | EBI | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007931 guanine nucleotide exchange factor GEFT
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183551 Fan X, et al., Geft is dispensable for the development of the second heart field. BMB Rep. 2012 Mar;45(3):153-8
All references(39)
Other
accession IDs
MGI:1919219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory