Arhgef25
Gene Detail

Symbol Name ID

Arhgef25 Rho guanine nucleotide exchange factor (GEF) 25 MGI:1277173

Synonyms

2410008H17Rik, D10Ertd610e, GEFT

Feature Type

protein coding gene

Genetic Map

Chromosome 10

74.50 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:127182521-127190054 bp, - strand From NCBI annotation of GRCm38   7534 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: RhoA guanine nucleotide exchange factor p63RhoAGef
Gene Tree: Arhgef25

Human homologs

Human Homolog		ARHGEF25, Rho guanine nucleotide exchange factor (GEF) 25
NCBI Gene ID		115557
neXtProt AC		NX_Q86VW2
Human Synonyms		GEFT, p63RhoGEF
Human Chr (Location)		12q13.3; chr12:58003963-58011028 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(1) Gene trapped(8)
 

Mice homozygous for a conditional allele activated in the second heart field exhibit normal cardiac development and prenatal survival.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	regulation of Rho protein signal transduction
Component	cytoplasm, membrane, ...
Function	guanyl-nucleotide exchange factor activity, phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (69)    Tissues (49)    Images (21)
Theiler Stages: 17, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	59
Northern blot	6
RT-PCR	4

cDNA source data(72)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) cDNA(72) Primer pair(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000019467 (Evidence)
Entrez Gene	52666 (Evidence)
UniGene	272230
DFCI	TC1577945, TC1589942, TC1662916, TC1739643
DoTS	DT.101153105, DT.101331656, DT.101379341, DT.102534309, DT.531319, DT.97353967
NIA Mouse Gene Index	U032327
Consensus CDS Project	CCDS24231.1, CCDS48715.1
International Mouse Knockout Project Status	Arhgef25

Sequences

Length	Strain/Species
genomic	52666	NCBI Gene Model | MGI Sequence Detail	7534	C57BL/6J
transcript	NM_028027	RefSeq | MGI Sequence Detail	2261	C57BL/6
polypeptide	Q9CWR0	UniProt | EBI | MGI Sequence Detail	618	Not Applicable

All sequences(38) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000007931	guanine nucleotide exchange factor GEFT

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183551 Fan X, et al., Geft is dispensable for the development of the second heart field. BMB Rep. 2012 Mar;45(3):153-8
All references(39)

Other accession IDs

MGI:1919219