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Arhgef25
Gene Detail
Symbol

Name
ID
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
MGI:1277173
Synonyms
2410008H17Rik, D10Ertd610e, GEFT
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.50 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:127182521-127190054 bp, - strand
From Ensembl annotation of GRCm38

  7534 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: RhoA guanine nucleotide exchange factor p63RhoAGef
Gene Tree: Arhgef25

Human
homologs
Human Homolog ARHGEF25, Rho guanine nucleotide exchange factor (GEF) 25
NCBI Gene ID 115557
neXtProt AC  NX_Q86VW2
Human Synonyms  GEFT, p63RhoGEF
Human Chr (Location)  12q13.3; chr12:57610180-57617245 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(8) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a conditional allele activated in the second heart field exhibit normal cardiac development and prenatal survival.
 
Interactions
Arhgef25 interacts with 65 markers (Mir15a, Mir18b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process regulation of Rho protein signal transduction
Component cytoplasm, membrane, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (69)    Tissues (49)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 59
Northern blot 6
RT-PCR 4
cDNA source data(72)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(72) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000019467 (Evidence)
Entrez Gene52666 (Evidence)
UniGene272230
DFCITC1589942, TC1577945, TC1739643, TC1662916
DoTSDT.101153105, DT.97353967, DT.531319, DT.102534309, DT.101379341, DT.101331656
NIA Mouse Gene IndexU032327
Consensus CDS ProjectCCDS24231.1, CCDS48715.1
International Mouse Knockout Project StatusArhgef25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019467 Ensembl Gene Model | MGI Sequence Detail 7534 C57BL/6J ±  kb
transcript ENSMUST00000019611 Ensembl | MGI Sequence Detail 2261 Not Applicable 
polypeptide ENSMUSP00000019611 Ensembl | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007931 rho guanine nucleotide exchange factor 25
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183551 Fan X, et al., Geft is dispensable for the development of the second heart field. BMB Rep. 2012 Mar;45(3):153-8
All references(40)
Other
accession IDs
MGI:1919219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory