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Arhgef25 Gene Detail
Summary
  • Symbol
    Arhgef25
  • Name
    Rho guanine nucleotide exchange factor (GEF) 25
  • Synonyms
    2410008H17Rik, D10Ertd610e, GEFT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277173
    NCBI Gene: 52666
  • Gene Overview
    MyGene.info: ARHGEF25
Location & Maps
more
  • Sequence Map
    Chr10:127182521-127190054 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7534 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARHGEF25, Rho guanine nucleotide exchange factor 25
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ARHGEF25, Rho guanine nucleotide exchange factor 25
    Orthology source: HomoloGene
  • Synonyms
    GEFT, p63RhoGEF
  • Links
    NCBI Gene ID: 115557
    neXtProt AC: NX_Q86VW2

  • Chr Location
    12q13.3; chr12:57610180-57617245 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
  • All Mutations and Alleles
    9
  • Gene trapped
    8
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for a conditional allele activated in the second heart field exhibit normal cardiac development and prenatal survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019467 Ensembl Gene Model | MGI Sequence Detail 7534 C57BL/6J ±  kb
transcript ENSMUST00000019611 Ensembl | MGI Sequence Detail 2261 Not Applicable  
polypeptide ENSMUSP00000019611 Ensembl | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007931 rho guanine nucleotide exchange factor 25
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR030738 Rho guanine nucleotide exchange factor 25
Molecular
Reagents
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  • All nucleic 75
    cDNA 72
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGI:1919219
References
more
  • Summaries
    All 36
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:183551 Fan X, et al., Geft is dispensable for the development of the second heart field. BMB Rep. 2012 Mar;45(3):153-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory