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Ncoa2
Gene Detail
 Symbol
Name
ID
Ncoa2
nuclear receptor coactivator 2
MGI:1276533
Synonyms bHLHe75, D1Ertd433e, glucocorticoid receptor-interacting protein 1, Grip1, KAT13C, SRC-2, TIF2, TIF-2, TIF2/GRIP-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
4.12 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:13139105-13374083 bp, - strand
From VEGA annotation of GRCm38

  234979 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4768  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nuclear receptor coactivator
Gene Tree: Ncoa2

Human
homologs
Human Homolog NCOA2, nuclear receptor coactivator 2
NCBI Gene ID 10499
neXtProt AC  NX_Q15596
Human Synonyms  bHLHe75, GRIP1, KAT13C, NCoA-2, SRC2, TIF2
Human Chr (Location)  8q13.3; chr8:70109768-70403827 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(39) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a transient postnatal growth deficiency and hypofertility. Male hypofertility is due to defects in spermiogenesis and an age-dependent testicular degeneration preceded by defective lipid metabolism in Sertoli cells. Female hypofertility is due to a placental hypoplasia.
 
Interactions
Ncoa2 interacts with 449 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process negative regulation of transcription, DNA-templated, negative regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, dendrite, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (197)    Tissues (151)    Images (41)
Theiler Stages: 1, 2, 3, 4, 5, 17, 19, 20, 21, 23, 25, 26, 28
Assay TypeResults
RNA in situ 174
Northern blot 8
RT-PCR 15
cDNA source data(106)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) Genomic(1) cDNA(111) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000021630 (Evidence)
Ensembl Gene ModelENSMUSG00000005886 (Evidence)
Entrez Gene17978 (Evidence)
UniGene2537
DFCITC1579701, TC1588322, TC1606235, TC1617780
DoTSDT.101161119, DT.103565389, DT.94203537, DT.97357421
NIA Mouse Gene IndexU021128
PDB1L2I, 1OSV, 2Q6J, 2QAB, 2QGT, 2QGW, 2QPY, 2QSE, 2QXM, 2QZO, 3MNE, 3MNO, 3MNP, 1WM0, 2QA6, 2QA8, 2QH6, 2QR9
Consensus CDS ProjectCCDS35514.1, CCDS35515.1
International Mouse Knockout Project StatusNcoa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021630 VEGA Gene Model | MGI Sequence Detail 234979 C57BL/6J ±  kb
transcript OTTMUST00000051367 VEGA | MGI Sequence Detail 4897 Not Applicable 
polypeptide OTTMUSP00000024153 VEGA | MGI Sequence Detail 1462 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(14) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(1765 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010011 Domain of unknown function DUF1518
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR017426 Nuclear receptor coactivator
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
InterPro IPR008955 Nuclear receptor coactivator Src-1
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
InterPro IPR014935 Steroid receptor coactivator
Protein Ontology PR:000011041 nuclear receptor coactivator 2
References (Earliest) J:33918 Hong H, et al., GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4948-52
(Latest) J:210332 Kommagani R, et al., A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. Biol Reprod. 2014 Apr;90(4):75
All references(102)
Other
accession IDs
MGD-MRK-35900, MGI:107429, MGI:1196270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory