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Ncoa2 Gene Detail
Summary
  • Symbol
    Ncoa2
  • Name
    nuclear receptor coactivator 2
  • Synonyms
    bHLHe75, D1Ertd433e, glucocorticoid receptor-interacting protein 1, Grip1, KAT13C, SRC-2, TIF2, TIF-2, TIF2/GRIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276533
    NCBI Gene: 17978
  • Gene Overview
    MyGene.info: NCOA2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:13139105-13374083 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      234979 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 4.12 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NCOA2, nuclear receptor coactivator 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCOA2, nuclear receptor coactivator 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe75, GRIP1, KAT13C, NCoA-2, SRC2, TIF2
  • Links
    NCBI Gene ID: 10499
    neXtProt AC: NX_Q15596
    UniProt: Q15596

  • Chr Location
    8q13.3; chr8:70109762-70405390 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a transient postnatal growth deficiency and hypofertility. Male hypofertility is due to defects in spermiogenesis and an age-dependent testicular degeneration preceded by defective lipid metabolism in Sertoli cells. Female hypofertility is due to a placental hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021630 VEGA Gene Model | MGI Sequence Detail 234979 C57BL/6J ±  kb
    transcript OTTMUST00000051367 VEGA | MGI Sequence Detail 4897 Not Applicable  
    polypeptide OTTMUSP00000024153 VEGA | MGI Sequence Detail 1462 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      1748 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 122
      Genomic 1
      cDNA 114
      Primer pair 7

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35900, MGI:107429, MGI:1196270
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 18
      Gene Ontology 23
      Phenotypes 45
    • Earliest
      J:33918 Hong H, et al., GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4948-52
    • Latest
      J:256201 Rollins DA, et al., Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. Nat Commun. 2017 Nov 23;8(1):1739

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory