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Ncoa2 Gene Detail
Summary
  • Symbol
    Ncoa2
  • Name
    nuclear receptor coactivator 2
  • Synonyms
    bHLHe75, D1Ertd433e, glucocorticoid receptor-interacting protein 1, Grip1, KAT13C, SRC-2, TIF2, TIF-2, TIF2/GRIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276533
    NCBI Gene: 17978
  • Gene Overview
    MyGene.info: NCOA2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:13139105-13374083 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 4.12 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1748 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276533
protein coding gene Chr1:13139105-13374083 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015841
protein coding gene Chr1:10507454-10747721 (-)
A/J MGP_AJ_G0015823
protein coding gene Chr1:10477253-10707916 (-)
AKR/J MGP_AKRJ_G0015782
protein coding gene Chr1:10395027-10638570 (-)
BALB/cJ MGP_BALBcJ_G0015779
protein coding gene Chr1:10177012-10408293 (-)
C3H/HeJ MGP_C3HHeJ_G0015613
protein coding gene Chr1:10376372-10614992 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016233
protein coding gene Chr1:11016348-11256688 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013954
protein coding gene Chr1:9100095-9328283 (-)
CAST/EiJ MGP_CASTEiJ_G0015193
protein coding gene Chr1:10546672-10789049 (-)
CBA/J MGP_CBAJ_G0015586
protein coding gene Chr1:11259387-11512631 (-)
DBA/2J MGP_DBA2J_G0015685
protein coding gene Chr1:10081897-10310933 (-)
FVB/NJ MGP_FVBNJ_G0015690
protein coding gene Chr1:9913095-10141503 (-)
LP/J MGP_LPJ_G0015757
protein coding gene Chr1:10695992-10934289 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015709
protein coding gene Chr1:11975586-12219221 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016280
protein coding gene Chr1:10308189-10543153 (-)
PWK/PhJ MGP_PWKPhJ_G0014977
protein coding gene Chr1:9898461-10129868 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014758
protein coding gene Chr1:10532806-10769876 (-)
WSB/EiJ MGP_WSBEiJ_G0015257
protein coding gene Chr1:10320285-10559764 (-)



Homology
more
  • Human Ortholog
    NCOA2, nuclear receptor coactivator 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCOA2, nuclear receptor coactivator 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe75, GRIP1, KAT13C, NCoA-2, SRC2, TIF2
  • Links
    NCBI Gene ID: 10499
    neXtProt AC: NX_Q15596
    UniProt: Q15596

  • Chr Location
    8q13.3; chr8:70109762-70405390 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a transient postnatal growth deficiency and hypofertility. Male hypofertility is due to defects in spermiogenesis and an age-dependent testicular degeneration preceded by defective lipid metabolism in Sertoli cells. Female hypofertility is due to a placental hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17978 NCBI Gene Model | MGI Sequence Detail 234979 C57BL/6J ±  kb
    transcript NM_008678 RefSeq | MGI Sequence Detail 8286 C57BL/6  
    polypeptide Q61026 UniProt | EBI | MGI Sequence Detail 1462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      Genomic 1
      cDNA 114
      Primer pair 7

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35900, MGI:107429, MGI:1196270
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 18
      Gene Ontology 24
      Phenotypes 45
    • Earliest
      J:33918 Hong H, et al., GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4948-52
    • Latest
      J:256201 Rollins DA, et al., Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. Nat Commun. 2017 Nov 23;8(1):1739

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory