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Ncoa2
Gene Detail
Symbol

Name
ID
Ncoa2
nuclear receptor coactivator 2
MGI:1276533
Synonyms
bHLHe75, D1Ertd433e, glucocorticoid receptor-interacting protein 1, Grip1, KAT13C, SRC-2, TIF2, TIF-2, TIF2/GRIP-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
4.12 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:13139105-13374083 bp, - strand
From VEGA annotation of GRCm38

  234979 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4768  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NCOA2
Protein SuperFamily: nuclear receptor coactivator
Gene Tree: Ncoa2

Human
homologs
NCOA2, nuclear receptor coactivator 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10499
neXtProt AC: NX_Q15596

Human Synonyms: bHLHe75, GRIP1, KAT13C, NCoA-2, SRC2, TIF2

Human Chr (Location): 8q13.3; chr8:70109770-70405437 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(39) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice exhibit a transient postnatal growth deficiency and hypofertility. Male hypofertility is due to defects in spermiogenesis and an age-dependent testicular degeneration preceded by defective lipid metabolism in Sertoli cells. Female hypofertility is due to a placental hypoplasia.
 
Interactions
Ncoa2 interacts with 448 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process cellular response to hormone stimulus, cellular response to Thyroglobulin triiodothyronine, ...
Component cytoplasm, dendrite, ...
Function chromatin binding, DNA polymerase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (197)    Tissues (159)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 174
Northern blot 8
RT-PCR 15
cDNA source data(106)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NCOA2 ; Xenbase ncoa2 ; ZFIN ncoa2    NEW 
Molecular
reagents
All nucleic(116) Genomic(1) cDNA(111) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000021630 (Evidence)
Ensembl Gene Model ENSMUSG00000005886 (Evidence)
Entrez Gene 17978 (Evidence)
UniGene 2537
DFCI TC1579701, TC1588322, TC1606235, TC1617780
DoTS DT.101161119, DT.103565389, DT.94203537, DT.97357421
NIA Mouse Gene Index U021128
PDB 1L2I, 1OSV, 1WM0, 2Q6J, 2QA6, 2QA8, 2QAB, 2QGT, 2QGW, 2QH6, 2QPY, 2QR9, 2QSE, 2QXM, 2QZO, 3MNE, 3MNO, 3MNP
Consensus CDS Project CCDS35514.1, CCDS35515.1
International Mouse Phenotyping Consortium Status Ncoa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021630 VEGA Gene Model | MGI Sequence Detail 234979 C57BL/6J ±  kb
transcript OTTMUST00000051367 VEGA | MGI Sequence Detail 4897 Not Applicable 
polypeptide OTTMUSP00000024153 VEGA | MGI Sequence Detail 1462 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(27) UniProt(10)
Polymorphisms
RFLP(1) : SNPs within 2kb(1765 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010011 Domain of unknown function DUF1518
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR017426 Nuclear receptor coactivator
InterPro IPR028822 Nuclear receptor coactivator 2
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
InterPro IPR008955 Nuclear receptor coactivator Src-1
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
InterPro IPR014935 Steroid receptor coactivator
Protein Ontology PR:000011041 nuclear receptor coactivator 2
References
(Earliest) J:33918 Hong H, et al., GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4948-52
(Latest) J:220550 Dasgupta S, et al., Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest. 2015 Mar 2;125(3):1174-88
All references(108)
Other
accession IDs
MGD-MRK-35900, MGI:107429, MGI:1196270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory